Results 21 to 30 of about 503,680 (311)
Genes & Development, 2000 The activities of several mRNA processing factors are coupled to transcription through binding to RNA polymerase II (Pol II). The largest subunit of Pol II contains a repetitive carboxy-terminal domain (CTD) that becomes highly phosphorylated during ...
P. Komarnitsky, E. Cho, S. Buratowski
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PLoS ONE, 2014 Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle and RNA polymerase II mediated transcription. Several pharmacological CDK inhibitors are currently in clinical trials as potential cancer therapeutics and some of them also exhibit ...
Jitka Holcakova +8 more
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RNA polymerase II pausing during development [PDF]
Development, 2014 The rapid expansion of genomics methods has enabled developmental biologists to address fundamental questions of developmental gene regulation on a genome-wide scale. These efforts have demonstrated that transcription of developmental control genes by RNA polymerase II (Pol II) is commonly regulated at the transition to productive elongation, resulting
Bjoern, Gaertner, Julia, Zeitlinger
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Structural Transition of the Nucleosome during Transcription Elongation
Cells, 2023 In eukaryotes, genomic DNA is tightly wrapped in chromatin. The nucleosome is a basic unit of chromatin, but acts as a barrier to transcription. To overcome this impediment, the RNA polymerase II elongation complex disassembles the nucleosome during ...
Tomoya Kujirai +3 more
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SPT5 stabilization of promoter-proximal RNA polymerase II.
Molecules and Cells, 2021 Based on in vitro studies, it has been demonstrated that the DSIF complex, composed of SPT4 and SPT5, regulates the elongation stage of transcription catalyzed by RNA polymerase II (RNA Pol II). The precise cellular function of SPT5 is not clear, because
Y. Aoi +10 more
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Modulation of RNA primer formation by Mn(II)-substituted T7 DNA primase
Scientific Reports, 2017 Lagging strand DNA synthesis by DNA polymerase requires RNA primers produced by DNA primase. The N-terminal primase domain of the gene 4 protein of phage T7 comprises a zinc-binding domain that recognizes a specific DNA sequence and an RNA polymerase ...
Stefan Ilic +7 more
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The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity
Cell Reports, 2018 Summary: The RNA polymerase II-associated protein 1 (RPAP1) is conserved across metazoa and required for stem cell differentiation in plants; however, very little is known about its mechanism of action or its role in mammalian cells. Here, we report that
Cian J. Lynch +16 more
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SAF-A forms a complex with BRG1 and both components are required for RNA polymerase II mediated transcription. [PDF]
PLoS ONE, 2011 BACKGROUND: Scaffold attachment factor A (SAF-A) participates in the regulation of gene expression by organizing chromatin into transcriptionally active domains and by interacting directly with RNA polymerase II. METHODOLOGY: Here we use co-localization,
Dzeneta Vizlin-Hodzic +4 more
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iScience, 2023 Summary: THOC5, a member of the THO complex, is essential for the 3′processing of some inducible genes, the export of a subset of mRNAs and stem cell survival.
Mareike Polenkowski +10 more
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RNA Polymerase II: Just Stopping By [PDF]
Cell, 2007 In this issue of Cell, Guenther et al. (2007) analyze the presence of chromatin marks and RNA polymerase at transcription start sites in the human genome. Their results reveal that many "inactive" genes harbor histone marks associated with active transcription at their 5' ends and that although these genes initiate transcription, they do not generate ...
Lorincz, Matthew C., Schübeler, Dirk
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