Results 31 to 40 of about 503,680 (311)
Cap-specific terminal N6-methylation of RNA by an RNA polymerase II–associated methyltransferase
Science, 2019 A cap-specific m6A writer N6,2′-O-dimethyladenosine (m6Am) is present at the transcription start nucleotide of capped mRNAs in vertebrates. Akichika et al.
Shinichiro Akichika +10 more
semanticscholar +1 more source
RNA Polymerase II Elongation Control
Cold Spring Harbor Symposia on Quantitative Biology, 1998 Regulation of the elongation phase of transcription by RNA polymerase II (Pol II) is utilized extensively to generate the pattern of mRNAs needed to specify cell types and to respond to environmental changes. After Pol II initiates, negative elongation factors cause it to pause in a promoter proximal position. These polymerases are poised to respond to
J, Peng +4 more
openaire +2 more sources
Nucleolar RNA polymerase II drives ribosome biogenesis
Nature, 2020 Proteins are manufactured by ribosomes—macromolecular complexes of protein and RNA molecules that are assembled within major nuclear compartments called nucleoli 1 , 2 .
K. Abraham +24 more
semanticscholar +1 more source
Structure of transcribing RNA polymerase II-nucleosome complex
Nature Communications, 2018 Eukaryotic transcription requires passage of RNA polymerase II (Pol II) through chromatin, which is impaired by nucleosomes. Here the authors report the cryo-EM structure of transcribing Pol II engaged with a downstream nucleosome core particle at an ...
Lucas Farnung +2 more
doaj +1 more source
BMC Evolutionary Biology, 2004 Background The primate-specific Alu elements, which originated 65 million years ago, exist in over a million copies in the human genome. These elements have been involved in genome shuffling and various diseases not only through retrotransposition but ...
Brahmachari Samir K +3 more
doaj +1 more source
RNA Polymerase II Transcription Elongation Control [PDF]
Chemical Reviews, 2013 Regulation of gene expression is critical in determining cell identity, development and responses to the cellular environment. DNA is the inherited source of genetic information and regulation of gene expression starts with the selection of which genes will undergo transcription.
Jiannan, Guo, David H, Price
openaire +2 more sources
Effect of CFIm68 knockdown on RNA polymerase II transcription
BMC Research Notes, 2019 Objectives Transcription of eukaryotic protein-coding genes by RNA polymerase II (pol II) is highly regulated at initiation, elongation and termination.
Michael Tellier +3 more
doaj +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
RNA Polymerase II CTD phosphatase Rtr1 fine-tunes transcription termination.
PLoS Genetics, 2020 RNA Polymerase II (RNAPII) transcription termination is regulated by the phosphorylation status of the C-terminal domain (CTD). The phosphatase Rtr1 has been shown to regulate serine 5 phosphorylation on the CTD; however, its role in the regulation of ...
Jose F Victorino +10 more
doaj +1 more source
A two-state model for the dynamics of the pyrophosphate ion release in bacterial RNA polymerase. [PDF]
PLoS Computational Biology, 2013 The dynamics of the PPi release during the transcription elongation of bacterial RNA polymerase and its effects on the Trigger Loop (TL) opening motion are still elusive.
Lin-Tai Da +3 more
doaj +1 more source