Results 1 to 10 of about 310,443 (357)
The origin of RNA precursors on exoplanets. [PDF]
Sci Adv, 2018 Researchers identify an “abiogenesis zone,” outside of which the building blocks of life cannot form photochemically.
Rimmer PB +5 more
europepmc +9 more sources
A continuous reaction network that produces RNA precursors. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance RNA may have been the original polymer to arise spontaneously on the early Earth through natural geochemistry. Although direct physical evidence regarding early Earth’s geochemistry is extremely limited, complex chemical reaction networks are thought to have played an important role in chemical evolution.
Yi R +6 more
europepmc +5 more sources
Maturation of atypical ribosomal RNA precursors in Helicobacter pylori. [PDF]
Nucleic Acids Res, 2019 In most bacteria, ribosomal RNA is transcribed as a single polycistronic precursor that is first processed by RNase III. This double-stranded specific RNase cleaves two large stems flanking the 23S and 16S rRNA mature sequences, liberating three 16S, 23S and 5S rRNA precursors, which are further processed by other ribonucleases.
Iost I, Chabas S, Darfeuille F.
europepmc +5 more sources
Degradation of ribosomal RNA precursors by the exosome [PDF]
Nucleic Acids Research, 2000 The yeast exosome is a complex of 3'-->5' exonucleases involved in RNA processing and degradation. All 11 known components of the exosome are required during 3' end processing of the 5.8S rRNA. Here we report that depletion of each of the individual components inhibits the early pre-rRNA cleavages at sites A(0), A(1), A(2)and A(3), reducing the levels ...
Allmang, Christine +3 more
openaire +5 more sources
Splicing of Messenger RNA Precursors
Science, 1987 A general mechanism for the splicing of nuclear messenger RNA precursors in eukaryotic cells has been widely accepted. This mechanism, which generates lariat RNAs possessing a branch site, seems related to the RNA-catalyzed reactions of self-splicing introns.
Sharp, P. A. +5 more
openaire +8 more sources
RNA editing of a miRNA precursor: FIGURE 1. [PDF]
RNA, 2004 Micro RNAs comprise a large family of small, functional RNAs with important roles in the regulation of protein coding genes in animals and plants. Here we show that human and mouse miRNA22 precursor molecules are subject to posttranscriptional modification by A-to-I RNA editing in vivo.
Stefan Maas +3 more
openaire +3 more sources
Uridylation and adenylation of RNAs. [PDF]
, 2015 The posttranscriptional addition of nontemplated nucleotides to the 3' ends of RNA molecules can have a significant impact on their stability and biological function.
Chen, XueMei +3 more
core +2 more sources
Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma. [PDF]
, 2015 Background: ADAR enzymes convert adenosines to inosines within double-stranded RNAs, including microRNA (miRNA) precursors, with important consequences on miRNA retargeting and expression.
Alon, S +10 more
core +2 more sources
Sox9-Meis1 Inactivation Is Required for Adipogenesis, Advancing Pref-1+ to PDGFRα+ Cells. [PDF]
, 2018 Adipocytes arise from the commitment and differentiation of adipose precursors in white adipose tissue (WAT). In studying adipogenesis, precursor markers, including Pref-1 and PDGFRα, are used to isolate precursors from stromal vascular fractions of WAT,
Gulyaeva, Olga +4 more
core +1 more source
Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types. [PDF]
, 2017 Many subtypes of cortical interneurons (CINs) are found in adult mouse cortices, but the mechanism generating their diversity remains elusive. We performed single-cell RNA sequencing on the mouse embryonic medial ganglionic eminence (MGE), the major ...
Chen, Ying-Jiun J +7 more
core +1 more source