The origin of RNA precursors on exoplanets. [PDF]
Sci Adv, 2018 Researchers identify an “abiogenesis zone,” outside of which the building blocks of life cannot form photochemically.
Rimmer PB +5 more
europepmc +9 more sources
RNA-binding protein immunoprecipitation as a tool to investigate plant miRNA processing interference by regulatory proteins of diverse origin [PDF]
Plant Methods, 2018 Background Due to the nature of viral RNA genomes, RNA viruses depend on many RNA-binding proteins (RBP) of viral and host origin for replication, dissemination and evasion of host RNA degradation pathways. Some viruses interfere with the microRNA (miRNA)
F. E. Marmisolle +2 more
doaj +4 more sources
ADAR2-mediated editing of miR-214 and miR-122 precursor and antisense RNA transcripts in liver cancers. [PDF]
PLoS ONE, 2013 A growing list of microRNAs (miRNAs) show aberrant expression patterns in hepatocellular carcinoma (HCC), but the regulatory mechanisms largely remain unclear.
Wan-Hsin Liu +7 more
doaj +3 more sources
A continuous reaction network that produces RNA precursors. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance RNA may have been the original polymer to arise spontaneously on the early Earth through natural geochemistry. Although direct physical evidence regarding early Earth’s geochemistry is extremely limited, complex chemical reaction networks are thought to have played an important role in chemical evolution.
Yi R +6 more
europepmc +4 more sources
The H3K27me3 reader UAD-2 recruits a TAF-12-containing transcription machinery to initiate piRNA expression within heterochromatic clusters [PDF]
Nature CommunicationsMetazoans utilize the small RNA pathway to regulate gene expression and maintain genome integrity. This pathway directs histone H3 lysine 9 tri-methylation (H3K9me3) or histone H3 lysine 27 tri-methylation (H3K27me3) at target loci to induce ...
Xinya Huang +13 more
doaj +2 more sources
Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features [PDF]
eLifeHuman cone photoreceptors differ from rods and serve as the retinoblastoma cell-of-origin, yet the developmental basis for their distinct behaviors is poorly understood. Here, we used deep full-length single-cell RNA-sequencing (scRNA-seq) to distinguish
Dominic WH Shayler +20 more
doaj +2 more sources
Contribution of Small RNA Pathway to Interactions of Rice with Pathogens and Insect Pests
Rice, 2021 Small RNAs (sRNAs) are mainly classified into microRNAs (miRNAs) and small interfering RNAs (siRNAs) according to their origin. miRNAs originate from single-stranded RNA precursors, whereas siRNAs originate from double-stranded RNA precursors that are ...
Qin Feng +3 more
doaj +1 more source
The role of human Dicer-dsRBD in processing small regulatory RNAs. [PDF]
PLoS ONE, 2012 One of the most exciting recent developments in RNA biology has been the discovery of small non-coding RNAs that affect gene expression through the RNA interference (RNAi) mechanism.
Christopher Wostenberg +6 more
doaj +1 more source
Inflammation and Regeneration, 2023 Background Rheumatoid arthritis (RA) is characterized by chronic inflammation and resultant cartilage/bone destruction because of aberrantly activated osteoclasts.
Shinya Yari +8 more
doaj +1 more source
The Role of Adipocyte Precursors in Development and Obesity
Frontiers in Endocrinology, 2021 Maintenance of adipocyte precursors is critical for regulating metabolism and preventing obesity related disease. These precursors have been immortalized and studied in cellular models as well as—more recently—in animal models.
Tammy Ying +3 more
doaj +1 more source