Polyadenylation of stable RNA precursors in vivo [PDF]
Proceedings of the National Academy of Sciences, 1998 Polyadenylation at the 3′ terminus has long been considered a specific feature of mRNA and a few other unstable RNA species. Here we show that stable RNAs in Escherichia coli can be polyadenylated as well. RNA molecules with poly(A) tails are the major products that accumulate for essentially all stable RNA ...
Z, Li, S, Pandit, M P, Deutscher
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A continuous reaction network that produces RNA precursors. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance RNA may have been the original polymer to arise spontaneously on the early Earth through natural geochemistry. Although direct physical evidence regarding early Earth’s geochemistry is extremely limited, complex chemical reaction networks ...
Yi R +6 more
europepmc +2 more sources
Antisense Transcription of Retrotransposons in Drosophila: An Origin of Endogenous Small Interfering RNA Precursors. [PDF]
Genetics, 2016 Russo J, Harrington AW, Steiniger M.
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Extensive degradation of RNA precursors by the exosome in wild-type cells. [PDF]
Mol Cell, 2012 Summary The exosome is a complex involved in the maturation of rRNA and sn-snoRNA, the degradation of short lived non-coding RNAs and in the quality control of RNAs produced in mutants.
Gudipati RK +6 more
europepmc +2 more sources
Means to an end: mechanisms of alternative polyadenylation of messenger RNA precursors. [PDF]
Wiley Interdiscip Rev RNA, 2014 Expression of mature messenger RNAs (mRNAs) requires appropriate transcription initiation and termination, as well as pre‐mRNA processing by capping, splicing, cleavage, and polyadenylation.
Gruber AR +3 more
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Degradation of ribosomal RNA precursors by the exosome [PDF]
Nucleic Acids Research, 2000 The yeast exosome is a complex of 3'-->5' exonucleases involved in RNA processing and degradation. All 11 known components of the exosome are required during 3' end processing of the 5.8S rRNA. Here we report that depletion of each of the individual components inhibits the early pre-rRNA cleavages at sites A(0), A(1), A(2)and A(3), reducing the levels ...
Allmang, Christine +3 more
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Trim25 is an RNA-specific activator of Lin28a/TuT4-mediated uridylation [PDF]
, 2014 RNA binding proteins have thousands of cellular RNA targets and often exhibit opposite or passive molecular functions. Lin28a is a conserved RNA binding protein involved in pluripotency and tumorigenesis that was previously shown to trigger TuT4-mediated
Nowak, Jakub S. +14 more
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From Formamide to RNA, the Path Is Tenuous but Continuous
Life, 2015 Reactions of formamide (NH2COH) in the presence of catalysts of both terrestrial and meteoritic origin yield, in plausible and variegated conditions, a large panel of precursors of (pre)genetic and (pre)metabolic interest. Formamide chemistry potentially
Samanta Pino +4 more
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The Drosophila ZAD zinc finger protein Kipferl guides Rhino to piRNA clusters
eLife, 2022 RNA interference systems depend on the synthesis of small RNA precursors whose sequences define the target spectrum of these silencing pathways. The Drosophila Heterochromatin Protein 1 (HP1) variant Rhino permits transcription of PIWI-interacting RNA ...
Lisa Baumgartner +5 more
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Ribosomal Precursor RNA in Saccharomyces carlsbergensis [PDF]
European Journal of Biochemistry, 1967 Several lines of evidence for the occurrence of ribosomal precursor RNA in yeast are presented. This ribosomal precursor RNA has been found in the nuclear fraction, it is rapidly labeled with radioactive nucleotides and sediments faster than the two ribosomal RNAs.
J, Retèl, R J, Planta
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