MicroRNA-122 dependent binding of Ago2 protein to hepatitis C virus RNA is associated with enhanced RNA stability and translation stimulation. [PDF]
PLoS ONE, 2013 Translation of Hepatitis C Virus (HCV) RNA is directed by an internal ribosome entry site (IRES) in the 5'-untranslated region (5'-UTR). HCV translation is stimulated by the liver-specific microRNA-122 (miR-122) that binds to two binding sites between ...
K Dominik Conrad +6 more
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Degradation of ribosomal RNA precursors by the exosome [PDF]
Nucleic Acids Research, 2000 The yeast exosome is a complex of 3'-->5' exonucleases involved in RNA processing and degradation. All 11 known components of the exosome are required during 3' end processing of the 5.8S rRNA. Here we report that depletion of each of the individual components inhibits the early pre-rRNA cleavages at sites A(0), A(1), A(2)and A(3), reducing the levels ...
Allmang, Christine +3 more
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From Formamide to RNA, the Path Is Tenuous but Continuous
Life, 2015 Reactions of formamide (NH2COH) in the presence of catalysts of both terrestrial and meteoritic origin yield, in plausible and variegated conditions, a large panel of precursors of (pre)genetic and (pre)metabolic interest. Formamide chemistry potentially
Samanta Pino +4 more
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The Drosophila ZAD zinc finger protein Kipferl guides Rhino to piRNA clusters
eLife, 2022 RNA interference systems depend on the synthesis of small RNA precursors whose sequences define the target spectrum of these silencing pathways. The Drosophila Heterochromatin Protein 1 (HP1) variant Rhino permits transcription of PIWI-interacting RNA ...
Lisa Baumgartner +5 more
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Ribosomal Precursor RNA in Saccharomyces carlsbergensis [PDF]
European Journal of Biochemistry, 1967 Several lines of evidence for the occurrence of ribosomal precursor RNA in yeast are presented. This ribosomal precursor RNA has been found in the nuclear fraction, it is rapidly labeled with radioactive nucleotides and sediments faster than the two ribosomal RNAs.
J, Retèl, R J, Planta
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Diversity of Endonuclease V: From DNA Repair to RNA Editing
Biomolecules, 2015 Deamination of adenine occurs in DNA, RNA, and their precursors via a hydrolytic reaction and a nitrosative reaction. The generated deaminated products are potentially mutagenic because of their structural similarity to natural bases, which in turn leads
Isao Kuraoka
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Argonaute-dependent small RNAs derived from single-stranded non-structured precursors
Frontiers in Genetics, 2014 A general feature of Argonaute-dependent small RNAs is their base-paired precursor structures, and precursor duplex structures are often required for confident annotation of miRNA genes.
Li-Ling eChak +2 more
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Detection and Phylogenetic Analysis of Group 1 Coronaviruses in South American Bats
Emerging Infectious Diseases, 2008 Bat coronaviruses (Bt-CoVs) are thought to be the precursors of severe acute respiratory syndrome coronavirus. We detected Bt-CoVs in 2 bat species from Trinidad.
Christine V.F. Carrington +9 more
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Export of piRNA precursors by EJC triggers assembly of cytoplasmic Yb-body in Drosophila
Nature Communications, 2016 In Drosophila ovarian follicle cells, piRNAs generated from RNA precursors are processed in cytoplasmic Yb-bodies. The authors identify the exportin and the exon junction complexes as required to transfer precursors to cytoplasm.
Cynthia Dennis +3 more
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Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly
Nature Communications, 2023 The U2 snRNP recognizes the intron during spliceosome assembly. Here the authors report the high-resolution structures of two assembly precursors of human U2 snRNP and reveal that the RNA helicases DDX42 and DDX46 are mutually exclusive in terms of SF3B1-
Fenghua Yang +7 more
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