Results 241 to 250 of about 310,443 (357)

Key Connectomes and Synaptic‐Compartment‐Specific Risk Genes Drive Pathological α‐Synuclein Spreading

Advanced Science, EarlyView.
Utilizing a stereotaxic injection mouse model and a novel mathematical approach, this study uncovers key subnetworks that drive pathological α‐synuclein (α‐Syn) progression in Parkinson's disease (PD). Remarkably, just 2% of the strongest connections in the connectome are sufficient to predict its spread.
Yuanxi Li, Justin Torok, Shujing Zhang, Jessica Ding, Ning Wang, Courtney Lau, Shruti Kulkarni, Chaitali Anand, Julie Tran, Michael Cheng, Claire Lo, Binbin Lu, Yanzi Sun, Robert Damoiseaux, Xia Yang, Ashish Raj, Chao Peng   +16 more
wiley   +1 more source

Comparison of potential nuclear precursors for prolactin and growth hormone messenger RNA.

, 1980
R A Maurer, Earl J. Gubbins, Christopher R. Erwin, J E Donelson   +3 more
openalex   +1 more source

In vitro analysis of processing at the 3'-end of precursors of M1 RNA, the catalytic subunit of Escherichia coli RNase P: Multiple pathways and steps for the processing [PDF]

, 1999
Semi Kim, Soyeong Sim, Younghoon Lee
openalex   +1 more source

An organ-specific transcriptome atlas of Curcuma wenyujin: MicroRNAs, phasiRNAs, and metabolic pathways. [PDF]

Plant Genome
Ma X, Tang Y, Feng Z, Yin X, Meng Y, Yin X, Xie T.   +6 more
europepmc   +1 more source

KDM6A Deficiency Induces Myeloid Bias and Promotes CMML‐Like Disease Through JAK/STAT3 Activation by Repressing SOCS3

Advanced Science, EarlyView.
Lysine demethylase 6A (KDM6A), an epigenetic regulator expressed in hematopoietic stem and progenitor cells (HSPCs), plays a critical role in hematopoietic homeostasis. Deficiency of KDM6A induces myeloid lineage skewing and drives the development of a chronic myelomonocytic leukemia (CMML)‐like disease.
Huiqiao Chen, Shufen Wang, Ruoyu Dong, Pinghui Yu, Tianyu Li, Liangning Hu, Mowang Wang, Zijun Qian, Hongyu Zhou, Xiaoyan Yue, Limengmeng Wang, Haowen Xiao   +11 more
wiley   +1 more source

TEL-AML1 fusion RNA as a new target to detect minimal residual disease in pediatric B-cell precursor acute lymphoblastic leukemia [PDF]

, 1996
JM Cayuela, André Baruchel, C Orange, A Madani, MF Auclerc, MT Daniel, G Schaison, F Sigaux   +7 more
openalex   +1 more source

Identification and Characterization of Copper-Responsive miRNAs and Their Target Genes in Jerusalem Artichoke. [PDF]

Plants (Basel)
Chen X, Shao T, Dong W, Lin J, Dai L, Ma Y, Zhou Z, Long X.   +7 more
europepmc   +1 more source

Real‐Time Evolutionary Landscape of the Bronchial Epithelium and Corresponding Dynamic Immune Cell Alterations in Lung Squamous Cell Carcinogenesis

Advanced Science, EarlyView.
Lung squamous cell carcinoma (LUSC) is often preceded by sequential premalignant lesions with an increasing probability of malignant progression. Using single‐cell RNA sequencing, the dynamic cellular evolution from normal lung to LUSC tissues is delineated; clonal structure of premalignant and malignant epithelium is reveled; the conversion of immune ...
Baohong Luo, Yuting Luo, Sicheng Chen, Tiantian Yang, Bixia Liu, Xiting Liao, Xiaoke Zheng, Tian Tian, Jinxu Liu, Qinru Zhan, Xiaohua Situ, Zhongpeng Xie, Yanxia Wang, Zhe‐Sheng Chen, Honglei Chen, Zheng Yang, Zunfu Ke   +16 more
wiley   +1 more source

Vault RNAs (vtRNAs): Rediscovered non-coding RNAs with diverse physiological and pathological activities

Genes and Diseases
The physicochemical characteristics of RNA admit non-coding RNAs to perform a different range of biological acts through various mechanisms and are involved in regulating a diversity of fundamental processes.
Mahsa Aghajani Mir
doaj  

Accelerated senescence of bone marrow erythrocyte precursors in myelodysplastic syndrome. [PDF]

Ann Med
Liu M, Yang L, Liu Y, Niu H, Zhang M, Shao Z, Xing L, Wang H.   +7 more
europepmc   +1 more source