Inflammation and Regeneration, 2023 Background Rheumatoid arthritis (RA) is characterized by chronic inflammation and resultant cartilage/bone destruction because of aberrantly activated osteoclasts.
Shinya Yari +8 more
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ADAR2-mediated editing of miR-214 and miR-122 precursor and antisense RNA transcripts in liver cancers. [PDF]
PLoS ONE, 2013 A growing list of microRNAs (miRNAs) show aberrant expression patterns in hepatocellular carcinoma (HCC), but the regulatory mechanisms largely remain unclear.
Wan-Hsin Liu +7 more
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The Role of Adipocyte Precursors in Development and Obesity
Frontiers in Endocrinology, 2021 Maintenance of adipocyte precursors is critical for regulating metabolism and preventing obesity related disease. These precursors have been immortalized and studied in cellular models as well as—more recently—in animal models.
Tammy Ying +3 more
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Non-Coding RNA Analyses of Seasonal Cambium Activity in Populus tomentosa
Cells, 2022 Non-coding RNA, known as long non-coding RNA (lncRNA), circular RNA (circRNA) and microRNA (miRNA), are taking part in the multiple developmental processes in plants.
Huimin Xu +10 more
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Origin of Biological Homochirality by Crystallization of an RNA Precursor on a Magnetic Surface [PDF]
Sci. Adv. 9, (2023), 2023 Homochirality is a signature of life on Earth yet its origins remain an unsolved puzzle. Achieving homochirality is essential for a high-yielding prebiotic network capable of producing functional polymers like ribonucleic acid (RNA) and peptides. However, a prebiotically plausible and robust mechanism to reach homochirality has not been shown to this ...
arxiv +1 more source
MicroRNA-122 dependent binding of Ago2 protein to hepatitis C virus RNA is associated with enhanced RNA stability and translation stimulation. [PDF]
PLoS ONE, 2013 Translation of Hepatitis C Virus (HCV) RNA is directed by an internal ribosome entry site (IRES) in the 5'-untranslated region (5'-UTR). HCV translation is stimulated by the liver-specific microRNA-122 (miR-122) that binds to two binding sites between ...
K Dominik Conrad +6 more
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Chirality-Induced Magnetization of Magnetite by an RNA Precursor [PDF]
Nat Commun 14, 6351 (2023), 2023 Life is homochiral and homochirality is a fundamental feature of living systems on Earth. While the exact mechanism that led to homochirality is still not fully understood, any realistic scenario on the origins of life needs to address the emergence of homochirality.
arxiv +1 more source
From Formamide to RNA, the Path Is Tenuous but Continuous
Life, 2015 Reactions of formamide (NH2COH) in the presence of catalysts of both terrestrial and meteoritic origin yield, in plausible and variegated conditions, a large panel of precursors of (pre)genetic and (pre)metabolic interest. Formamide chemistry potentially
Samanta Pino +4 more
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The Drosophila ZAD zinc finger protein Kipferl guides Rhino to piRNA clusters
eLife, 2022 RNA interference systems depend on the synthesis of small RNA precursors whose sequences define the target spectrum of these silencing pathways. The Drosophila Heterochromatin Protein 1 (HP1) variant Rhino permits transcription of PIWI-interacting RNA ...
Lisa Baumgartner +5 more
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Helical defects in microRNA influence protein binding by TAR RNA binding protein. [PDF]
PLoS ONE, 2015 MicroRNAs (miRNAs) are critical post-transcriptional regulators of gene expression. Their precursors have a globally A-form helical geometry, which prevents most proteins from identifying their nucleotide sequence. This suggests the hypothesis that local
Roderico Acevedo +3 more
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