Results 161 to 170 of about 436,191 (174)

De Novo Design of Integrin α5β1 Modulating Proteins to Enhance Biomaterial Properties

Advanced Materials, EarlyView.
NeoNectins are de novo‐designed miniproteins that selectively bind and stabilize the extended open form of integrin α5β1. When grafted onto biomaterials including hydrogel and titanium, they promote cell attachment and spreading in vitro and promoting tissue integration and bone growth in animal models, demonstrating broad potential for regenerative ...
Xinru Wang, Jordi Guillem‐Marti, Saurav Kumar, David S. Lee, Daniel Cabrerizo‐Aguado, Rachel Werther, Kevin Alexander Estrada Alamo, Yan Ting Zhao, Adam Nguyen, Irina Kopyeva, Buwei Huang, Jing Li, Yuxin Hao, Xinting Li, Aritza Brizuela‐Velasco, Analisa Murray, Stacey Gerben, Anindya Roy, Cole A. DeForest, Timothy Springer, Hannele Ruohola‐Baker, Jonathan A. Cooper, Melody G. Campbell, Jose Maria Manero, Maria‐Pau Ginebra, David Baker   +25 more
wiley   +1 more source

Adjusting Cell‐Surface Interactions Through a Covalent Immobilization of Biomolecules

Advanced Materials Interfaces, EarlyView.
This review presents an overview of current and emerging immobilization techniques coupled with an in‐depth investigation of the underlying mechanisms governing the activity and stability of covalently immobilized biomolecules. The aim of this study is to serve as a guide for the development of long‐lasting biomedical coatings with versatile biological
Sara Shakibania, Manus J. P. Biggs, Katarzyna Krukiewicz   +2 more
wiley   +1 more source

4D Bioprinted Self‐Folding Scaffolds Enhance Cartilage Formation in the Engineering of Trachea

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
A bilayer self‐folding scaffold, triggerable by humidity, is fabricated via 4D bioprinting for trachea engineering. An analytical model is derived to predict its radius of curvature, enabling its scalability. Cartilage progenitor cells seeded on the scaffold perceive scaffold final curvature and react to it, by enhancing the upregulation of pro ...
Irene Chiesa, Alessio Esposito, Giovanni Vozzi, Riccardo Gottardi, Carmelo De Maria   +4 more
wiley   +1 more source

Remote‐Controlled Wireless Bioelectronics for Fluoxetine Therapy to Promote Wound Healing in a Porcine Model

Advanced Materials Technologies, EarlyView.
A wireless bioelectronic ion pump platform is developed for controlled fluoxetine delivery for wound healing in a large mammal model. Over 3 days, treated wounds showed 37% greater re‐epithelialization and a 33% lower ratio of pro‐inflammatory to reparative macrophages.
Houpu Li, Narges Asefifeyzabadi, Kaelan Schorger, Prabhat Baniya, Hsin‐ya Yang, Maryam Tebyani, Alexie Barbee, Wan Shen Hee, Anthony Gallegos, Kan Zhu, Cynthia Recendez, Fan Lu, George Luka, Sujung Kim, Koushik Devarajan, Tiffany Nguyen, Sydnie Figuerres, Celeste Franco, Elham Aslankoohi, Héctor Carrión, Narges Norouzi, Marcella Gomez, Min Zhao, Roslyn Rivkah Isseroff, Mircea Teodorescu, Marco Rolandi   +25 more
wiley   +1 more source

Single‐Layer Radially Compartmentalized Paper Chip (RCP‐Chip) for Rapid Isothermal Multiplex Detection of SARS‐CoV‐2 Gene Targets

Advanced Sensor Research, EarlyView.
The single‐layer RCP‐Chip enables rapid, multiplexed detection of SARS‐CoV‐2 RNA using RT‐LAMP and gold nanoparticle‐enhanced colorimetric readouts. After sample loading, amplification occurs within radially arranged chambers, allowing simultaneous detection of E and N genes.
Pavithra Sukumar, Alla Saleh, Muhammedin Deliorman, Mohammad A. Qasaimeh   +3 more
wiley   +1 more source

Mimicking Biochemical Traits with a Synthetic Lipid Nanoparticles SARS‐COV‐2 Model

Advanced Therapeutics, Volume 8, Issue 6, June 2025.
A synthetic virus model developed using lipid nanoparticles, which incorporate encapsulated mRNA and nucleocapsid (N) protein along with surface‐conjugated spike (S) protein, mimics the characteristics of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), allowing for the advancement of diagnostic product assessment.
Ignasia Handipta Mahardika, Hyun Park, Eunjin Huh, Changyoon Baek, Shin‐Gyu Cho, Kwang‐Hwan Jung, Junhong Min, Kwanwoo Shin   +7 more
wiley   +1 more source

Cold Plasma Generates a Localized Inflammatory Response and Promotes Muscle Repair

Advanced Therapeutics, EarlyView.
The immediate tissue response to plasma is a pro‐inflammatory response which is characterized by collagen clumping, innate immune cell infiltration, enhanced metabolic processes, and decreased apoptosis. The long‐term tissue response (4‐ and 14‐days) to plasma treatment is characterized by a decreased inflammatory response, decreased adipogenesis, and ...
Carly J. Smith, Amanda R. Watkins, Abigail A. Lucas, Arianna J. Moniodes, Conn Ritchie, Thomas P. Thompson, Thomas P. Schaer, Brendan F. Gilmore, Noreen J. Hickok, Theresa A. Freeman   +9 more
wiley   +1 more source

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

Immune Checkpoint PD‐L1 Modulates Retinal Microglial Activation to Alleviate Vascular Leakage in Choroidal Neovascularization via ERK

Advanced Science, EarlyView.
PD‐L1 limits neuroinflammation in neovascular AMD by modulating microglial activation. Its deficiency exacerbates vascular leakage and choroidal neovascularization (CNV) via ERK signaling, while enhancing PD‐L1 reduces inflammation and neovascularization. Targeting PD‐L1 may offer a novel immunomodulatory strategy for NVAMD.
Yue Zou, Junliang Jiang, Yunqin Li, Xinyi Ding, Qiuping Tong, Ying Shi, Lei Xiao, Ling Chen   +7 more
wiley   +1 more source

FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron

Advanced Science, EarlyView.
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang, Yousheng Wu, Xuanlin Su, Kaiwei Cai, Man Ke, Niu He, Huili Zhu, Zefeng Tan, Jielin Zhu, Wensheng He, Min Peng, Shiqing Zhang, Hongcheng Mai, Anding Xu, Dan Lu   +14 more
wiley   +1 more source