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mSystemsThe archaeal domain contains organisms that are well-adapted to extreme conditions and changes in their habitat. Post-transcriptional regulation plays a key role in environmental adaptation, including rapid molecular responses to stress conditions.
Michel Brück +3 more
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Circadian rhythms and post-transcriptional regulation in higher plants
Frontiers in Plant Science, 2015 The circadian clock of plants allows them to cope with daily changes in their environment. This is accomplished by the rhythmic regulation of gene expression, in a process that involves many regulatory steps.
Andres eRomanowski +1 more
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Identification of human mitochondrial RNA cleavage sites and candidate RNA processing factors
BMC Biology, 2022 Background The human mitochondrial genome is transcribed as long strands of RNA containing multiple genes, which require post-transcriptional cleavage and processing to release functional gene products that play vital roles in cellular energy production.
Guillermo Carbajosa +2 more
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Transfer RNA Post-Transcriptional Processing, Turnover, and Subcellular Dynamics in the YeastSaccharomyces cerevisiae [PDF]
Genetics, 2013 AbstractTransfer RNAs (tRNAs) are essential for protein synthesis. In eukaryotes, tRNA biosynthesis employs a specialized RNA polymerase that generates initial transcripts that must be subsequently altered via a multitude of post-transcriptional steps before the tRNAs beome mature molecules that function in protein synthesis.
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Journal of Central Nervous System Disease, 2014 Background Expanded GGGGCC hexanucleotide repeats, ranging from hundreds to thousands in number, located in the noncoding region of the chromosome 9 open reading frame 72 ( C9orf72 ) gene represent the most common genetic abnormality for familial and ...
Jun-Ichi Satoh +5 more
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PLoS ONE, 2014 Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle and RNA polymerase II mediated transcription. Several pharmacological CDK inhibitors are currently in clinical trials as potential cancer therapeutics and some of them also exhibit antiviral effects.
Holčáková, J. +8 more
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Transcriptional and post-transcriptional processes regulate expression of RNA encoding the small subunit of ribulose-1, 5-biphosphate carboxylase differently in petunia and in soybean [PDF]
Nucleic Acids Research, 1990 The effects of white light, far-red light and darkness on the in vitro transcription and RNA levels of the small subunit of ribulose-1,5-bisphosphate carboxylase (rbcS) were investigated in petunia and in soybean. In petunia plants treated with 48 hours of darkness the in vitro transcription rate of two of the rbcS subfamilies of petunia, rbcS A and ...
D M, Thompson, R B, Meagher
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HIV latency reversing agents act through Tat post translational modifications
Retrovirology, 2018 Background Different classes of latency reversing agents (LRAs) are being evaluated to measure their effects in reactivating HIV replication from latently infected cells.
Georges Khoury +9 more
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Control of RNA degradation in cell fate decision
Frontiers in Cell and Developmental Biology, 2023 Cell fate is shaped by a unique gene expression program, which reflects the concerted action of multilayered precise regulation. Substantial research attention has been paid to the contribution of RNA biogenesis to cell fate decisions.
Mingqiang Deng +5 more
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Real-time transcriptional profiling of cellular and viral gene expression during lytic cytomegalovirus infection. [PDF]
, 2012 During viral infections cellular gene expression is subject to rapid alterations induced by both viral and antiviral mechanisms. In this study, we applied metabolic labeling of newly transcribed RNA with 4-thiouridine (4sU-tagging) to dissect the real ...
Lisa Marcinowski +46 more
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