Results 51 to 60 of about 203,837 (307)
Nature CommunicationsThe coordinated action of transcriptional and post-transcriptional machineries shapes gene expression programs at steady state and determines their concerted response to perturbations.
Lucia Coscujuela Tarrero +7 more
doaj +1 more source
Frontiers in Immunology, 2023 IntroductionBromodomain-containing Protein 4 (BRD4) is a transcriptional regulator which coordinates gene expression programs controlling cancer biology, inflammation, and fibrosis.
Morgan W. Mann +11 more
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
A genome-wide tethering screen reveals novel potential post-transcriptional regulators in Trypanosoma brucei. [PDF]
PLoS Pathogens, 2014 In trypanosomatids, gene expression is regulated mainly by post-transcriptional mechanisms, which affect mRNA processing, translation and degradation. Currently, our understanding of factors that regulate either mRNA stability or translation is rather ...
Esteban D Erben +4 more
doaj +1 more source
The FASEB Journal, 2019 Promoter‐proximal RNA Polymerase II pausing, which occurs within the first 100 nucleotides of a gene, refers to a property of the Polymerase II to halt transcription temporarily but remain transcriptionally competent. Knowledge of proximally paused Polymerase II dynamics is important for understanding the regulation of mRNA production.
Nii Koney‐Kwaku Koney +4 more
openaire +1 more source
Mycobacterial RNA isolation optimized for non-coding RNA: high fidelity isolation of 5S rRNA from Mycobacterium bovis BCG reveals novel post-transcriptional processing and a complete spectrum of modified ribonucleosides [PDF]
Nucleic Acids Research, 2014 A major challenge in the study of mycobacterial RNA biology is the lack of a comprehensive RNA isolation method that overcomes the unusual cell wall to faithfully yield the full spectrum of non-coding RNA (ncRNA) species. Here, we describe a simple and robust procedure optimized for the isolation of total ncRNA, including 5S, 16S and 23S ribosomal RNA (
Hia, Fabian +5 more
openaire +4 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Evolution of mitochondrial RNA editing sites and stop codon-lacking transcripts in angiosperms
Communications BiologyWhile the evolution of mitochondrial protein-coding genes in angiosperms has been extensively studied, the post-transcriptional RNA processing remains under-explored.
Runxian Yu +5 more
doaj +1 more source
Frontiers in Genetics, 2019 Nanopore sequencing from Oxford Nanopore Technologies (ONT) and Pacific BioSciences (PacBio) single-molecule real-time (SMRT) long-read isoform sequencing (Iso-Seq) are revolutionizing the way transcriptomes are analyzed.
Liangzhen Zhao +5 more
doaj +1 more source
An improved method for surface immobilisation of RNA: application to small Non-Coding RNA - mRNA pairing [PDF]
, 2013 Characterisation of RNA and its intermolecular interactions is increasing in importance as the inventory of known RNA functions continues to expand. RNA-RNA interactions are central to post-transcriptional gene regulation mechanisms in bacteria, and the ...
Darren M. Gowers (485354) +29 more
core +1 more source