Results 51 to 60 of about 442,476 (336)

Non-coding RNAs repressive role in post-transcriptional processing of RUNX2 during the acquisition of the osteogenic phenotype of periodontal ligament mesenchymal stem cells

open access: yesDevelopmental Biology, 2021
Mesenchymal stem cells are candidates for therapeutic strategies in periodontal repair due to their osteogenic potential. In this study, we identified epigenetic markers during osteogenic differentiation, taking advantage of the individual pattern of mesenchymal cells of the periodontal ligament with high (h-PDLCs) and low (l-PDLCs) osteogenic capacity.
Rahyza I.F. Assis   +10 more
openaire   +3 more sources

Identification of human mitochondrial RNA cleavage sites and candidate RNA processing factors

open access: yesBMC Biology, 2022
Background The human mitochondrial genome is transcribed as long strands of RNA containing multiple genes, which require post-transcriptional cleavage and processing to release functional gene products that play vital roles in cellular energy production.
Guillermo Carbajosa   +2 more
doaj   +1 more source

Control of RNA degradation in cell fate decision

open access: yesFrontiers in Cell and Developmental Biology, 2023
Cell fate is shaped by a unique gene expression program, which reflects the concerted action of multilayered precise regulation. Substantial research attention has been paid to the contribution of RNA biogenesis to cell fate decisions.
Mingqiang Deng   +5 more
doaj   +1 more source

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context [PDF]

open access: yes, 2018
Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling ...
Abdel-Rahman, Mohamed H.   +736 more
core   +3 more sources

Transcription Is Just the Beginning of Gene Expression Regulation: The Functional Significance of RNA-Binding Proteins to Post-transcriptional Processes in Plants [PDF]

open access: yesPlant and Cell Physiology, 2019
AbstractPlants have developed sophisticated mechanisms to compensate and respond to ever-changing environmental conditions. Research focus in this area has recently shifted towards understanding the post-transcriptional mechanisms that contribute to RNA transcript maturation, abundance and function as key regulatory steps in allowing plants to properly
Brian D Gregory   +2 more
openaire   +2 more sources

Molecular Network Analysis Suggests a Logical Hypothesis for the Pathological Role of C9orf72 in Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

open access: yesJournal of Central Nervous System Disease, 2014
Background Expanded GGGGCC hexanucleotide repeats, ranging from hundreds to thousands in number, located in the noncoding region of the chromosome 9 open reading frame 72 ( C9orf72 ) gene represent the most common genetic abnormality for familial and ...
Jun-Ichi Satoh   +5 more
doaj   +1 more source

HIV latency reversing agents act through Tat post translational modifications

open access: yesRetrovirology, 2018
Background Different classes of latency reversing agents (LRAs) are being evaluated to measure their effects in reactivating HIV replication from latently infected cells.
Georges Khoury   +9 more
doaj   +1 more source

(Alternative) transcription start sites as regulators of RNA processing.

open access: yesTrends in Cell Biology
Alternative transcription start site usage (ATSS) is a widespread regulatory strategy that enables genes to choose between multiple genomic loci for initiating transcription. This mechanism is tightly controlled during development and is often altered in
Carlos Alfonso-Gonzalez   +1 more
semanticscholar   +1 more source

Keratinocyte differentiation-dependent human papillomavirus gene regulation [PDF]

open access: yes, 2017
Human papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive cancers. HPVs infect epithelial cells and their replication cycle is tightly linked with the differentiation process of the infected keratinocyte.
Graham, Sheila V.
core   +1 more source

Post-transcriptional Processing of mRNA in Neurons: The Vestiges of the RNA World Drive Transcriptome Diversity

open access: yesFrontiers in Molecular Neuroscience, 2018
Neurons are morphologically complex cells that rely on the compartmentalization of protein expression to develop and maintain their extraordinary cytoarchitecture. This formidable task is achieved, at least in part, by targeting mRNA to subcellular compartments where they are rapidly translated.
Andreassi, C, Crerar, H, Riccio, A
openaire   +4 more sources

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