Results 61 to 70 of about 442,476 (336)

Bromodomain-containing Protein 4 regulates innate inflammation via modulation of alternative splicing

Frontiers in Immunology, 2023
IntroductionBromodomain-containing Protein 4 (BRD4) is a transcriptional regulator which coordinates gene expression programs controlling cancer biology, inflammation, and fibrosis.
Morgan W. Mann, Yao Fu, Robert L. Gearhart, Xiaofang Xu, David S. Roberts, Yi Li, Jia Zhou, Ying Ge, Ying Ge, Ying Ge, Allan R. Brasier, Allan R. Brasier   +11 more
doaj   +1 more source

Post-transcriptional regulation of gene expression and human disease.

Current Opinion in Cell Biology, 2018
A large number of mutations in genes that encode RNA binding proteins cause human disease. Many of these RNA binding proteins mediate key steps in post-transcriptional regulation of gene expression from mRNA processing to eventual decay in the cytoplasm.
A. Corbett
semanticscholar   +1 more source

Mutations in the mitochondrial cysteinyl-tRNA synthase gene, CARS2, lead to a severe epileptic encephalopathy and complex movement disorder [PDF]

, 2015
Background: Mitochondrial disease is often suspected in cases of severe epileptic encephalopathy especially when a complex movement disorder, liver involvement and progressive developmental regression are present.
Collins, Abigail E, Coughlin, Curtis R, II, Creadon-Swindell, Geralyn, Friederich, Marisa W, Geiger, Elizabeth A, Minczuk, Michal, Powell, Christopher A, Scharer, Gunter H, Shaikh, Tamim H, Swanson, Michael A, Van Coster, Rudy, Van Hove, Johan LK, Vanlander, Arnaud, Yu, Hung-Chun   +13 more
core   +2 more sources

Inhibition of Post-Transcriptional RNA Processing by CDK Inhibitors and Its Implication in Anti-Viral Therapy

PLoS ONE, 2014
Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle and RNA polymerase II mediated transcription. Several pharmacological CDK inhibitors are currently in clinical trials as potential cancer therapeutics and some of them also exhibit antiviral effects.
Holčáková, J., Müller, P., Tomasec, P., Hrstka, R., Nekulová, M., Kryštof, V. (Vladimír), Strnad, M. (Miroslav), Wilkinson, G. W. G., Vojtěšek, B.   +8 more
openaire   +5 more sources

Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex

RNA: A publication of the RNA Society, 2014
The authors define a multiprotein nuclear RNA silencing (NURS) complex that mediates silencing of meiotic genes during vegetative growth in the fission yeast S. pombe.
Emily D. Egan, C. Braun, S. Gygi, D. Moazed   +3 more
semanticscholar   +1 more source

Kinetic modelling of competition and depletion of shared miRNAs by competing endogenous RNAs

, 2018
Non-conding RNAs play a key role in the post-transcriptional regulation of mRNA translation and turnover in eukaryotes. miRNAs, in particular, interact with their target RNAs through protein-mediated, sequence-specific binding, giving rise to extended ...
A Arvey, A Baccarini, A Fatica, A Franks, A Helwak, A Joshi, A Loinger, A Martirosyan, A Martirosyan, A Nadal, A Raveh, A Re, A Riba, A Sanchez, A Sanchez-Mejias, AD Bosson, AK Leung, AM Gurtan, AS Flynt, B Du, B Obermayer, C Bosia, C Bosia, C Bosia, CW Hsu, D Baek, D Kim, DP Bartel, DP Bartel, DP Bartel, DT Gillespie, E Anastasiadou, E Berezikov, E Koller, E Levine, E Levine, FA Karreth, G Tkacik, H Liang, H Teimouri, I Alvarez-Garcia, I Bose, I Legnini, J Breda, J Das, J Fiorentino, J Kwon, J Noorbakhsh, J Tsang, JM Franco-Zorrilla, JM Schmiedel, L López-Maury, L Salmena, L Tsimring, M Chekulaeva, M Figliuzzi, M Figliuzzi, M Gerstein, M Jens, M Klein, M Mauri, M Nitzan, M Osella, M Osella, M Samoilov, MA Gibson, MA Valencia-Sanchez, MS Ebert, MS Ebert, NG Kampen Van, P Flondor, P Mehta, P Sumazin, PB Detwiler, PS Swain, R Denzler, R Denzler, RC Brewster, RC Friedman, RI Gregory, S Djuranovic, S Grigolon, S Guil, S Jonas, S Mukherji, S Pitchiaya, S Sass, S Wang, SD Chandradoss, TB Hansen, TR Cech, U Ala, U Alon, V Siciliano, X Lai, X Wang, X Yuan, Y Liang, Y Shimoni, Y Tay, Y Tay, Y Yuan   +101 more
core   +2 more sources

Transcriptional and post-transcriptional processes regulate expression of RNA encoding the small subunit of ribulose-1, 5-biphosphate carboxylase differently in petunia and in soybean [PDF]

Nucleic Acids Research, 1990
The effects of white light, far-red light and darkness on the in vitro transcription and RNA levels of the small subunit of ribulose-1,5-bisphosphate carboxylase (rbcS) were investigated in petunia and in soybean. In petunia plants treated with 48 hours of darkness the in vitro transcription rate of two of the rbcS subfamilies of petunia, rbcS A and ...
D M, Thompson, R B, Meagher
openaire   +2 more sources

Nanodynamo quantifies subcellular RNA dynamics revealing extensive coupling between steps of the RNA life cycle

Nature Communications
The coordinated action of transcriptional and post-transcriptional machineries shapes gene expression programs at steady state and determines their concerted response to perturbations.
Lucia Coscujuela Tarrero, Valeria Famà, Giacomo D’Andrea, Simone Maestri, Anna de Polo, Stefano Biffo, Mattia Furlan, Mattia Pelizzola   +7 more
doaj   +1 more source

The interplay between DNA damage response and RNA processing: the unexpected role of splicing factors as gatekeepers of genome stability

Frontiers in Genetics, 2015
Genome integrity is constantly threatened by endogenous and exogenous factors. However, its preservation is ensured by a network of pathways that prevent and/or repair the lesion, which constitute the DNA damage response (DDR).
C. Naro, P. Bielli, Vittoria Pagliarini, C. Sette   +3 more
semanticscholar   +1 more source

Virulence- and signaling-associated genes display a preference for long 3′UTRs during rice infection and metabolic stress in the rice blast fungus [PDF]

, 2019
Generation of mRNA isoforms by alternative polyadenylation (APA) and their involvement in regulation of fungal cellular processes, including virulence, remains elusive.
Demuez, Marie, Marconi, Marco, Ortega-Campayo, Víctor, Rodríguez-Romero, Julio, Sesma, Ane, Wilkinson, Mark D.   +5 more
core   +1 more source