Results 31 to 40 of about 19,175,801 (290)
Principles of RNA processing from analysis of enhanced CLIP maps for 150 RNA binding proteins
Genome Biology, 2019 A critical step in uncovering rules of RNA processing is to study the in vivo regulatory networks of RNA binding proteins (RBPs). Crosslinking and immunoprecipitation (CLIP) methods enable mapping RBP targets transcriptome-wide, but methodological ...
Eric L. Van Nostrand +16 more
semanticscholar +1 more source
CDK12 Activity-Dependent Phosphorylation Events in Human Cells
Biomolecules, 2019 We asked whether the C-terminal repeat domain (CTD) kinase, CDK12/CyclinK, phosphorylates substrates in addition to the CTD of RPB1, using our CDK12analog-sensitive HeLa cell line to investigate CDK12 activity-dependent phosphorylation events in human ...
Bartlomiej Bartkowiak +3 more
doaj +1 more source
HITS-CLIP yields genome-wide insights into brain alternative RNA processing
Nature, 2008 Protein–RNA interactions have critical roles in all aspects of gene expression. However, applying biochemical methods to understand such interactions in living tissues has been challenging.
D. D. Licatalosi +11 more
semanticscholar +1 more source
Mechanistic insights into non-coding Y RNA processing
RNA Biology, 2022 Y RNAs (84–112 nt) are non-coding RNAs transcribed by RNA polymerase III and are characterized by a distinctive secondary structure. Human Y RNAs interact with the autoimmune proteins SSB and RO60 that together form a ribonucleoprotein (RNP) complex ...
Martina Billmeier +7 more
doaj +1 more source
Adenovirus-mediated ubiquitination alters protein-RNA binding and aids viral RNA processing
Nature Microbiology, 2020 Viruses promote infection by hijacking the ubiquitin machinery of the host to counteract or redirect cellular processes. Adenovirus encodes two early proteins, E1B55K and E4orf6, that together co-opt a cellular ubiquitin ligase complex to overcome host ...
C. Herrmann +10 more
semanticscholar +1 more source
In vivo nuclear RNA structurome reveals RNA-structure regulation of mRNA processing in plants
Genome Biology, 2021 Background mRNA processing is critical for gene expression. A challenge in regulating mRNA processing is how to recognize the actual mRNA processing sites, such as splice and polyadenylation sites, when the sequence content is insufficient for this ...
Zhenshan Liu +8 more
doaj +1 more source
Altered RNA Processing in Cancer Pathogenesis and Therapy.
Cancer Discovery, 2019 Major advances in our understanding of cancer pathogenesis and therapy have come from efforts to catalog genomic alterations in cancer. A growing number of large-scale genomic studies have uncovered mutations that drive cancer by perturbing ...
Esther A. Obeng +2 more
semanticscholar +1 more source
The Interplay Between the DNA Damage Response, RNA Processing and Extracellular Vesicles
Frontiers in Oncology, 2020 RNA processing was recently found to affect DNA damage response. The RNA processing factors THRAP3 and BCLAF1 play critical role in keeping DNA genomic stability by regulating the transcription, mRNA splicing and export of DNA repair proteins BRCA2 ...
Xiangbing Meng +2 more
semanticscholar +1 more source
Identification of human mitochondrial RNA cleavage sites and candidate RNA processing factors
BMC Biology, 2022 Background The human mitochondrial genome is transcribed as long strands of RNA containing multiple genes, which require post-transcriptional cleavage and processing to release functional gene products that play vital roles in cellular energy production.
Guillermo Carbajosa +2 more
doaj +1 more source
Telomere maintenance: regulating hTERC fate through RNA modifications
Molecular & Cellular Oncology, 2019 Disturbances in telomere maintenance are common in cancer. We recently showed that Single-strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1) promotes telomere homeostasis by regulating the stability of the telomeric RNA component (hTERC ...
Lisa Lirussi, Hilde Nilsen
doaj +1 more source