Results 31 to 40 of about 1,048,276 (285)
Phosphoproteomics Screen Reveals Akt Isoform-Specific Signals Linking RNA Processing to Lung Cancer [PDF]
, 2014 The three Akt isoforms are functionally distinct. Here we show that their phosphoproteomes also differ, suggesting that their functional differences are due to differences in target specificity.
Ailan Guo +49 more
core +1 more source
The Crosstalk Between Epigenetic Mechanisms and Alternative RNA Processing Regulation
Frontiers in Genetics, 2020 As a co-transcriptional process, RNA processing, including alternative splicing and alternative polyadenylation, is crucial for the generation of multiple mRNA isoforms.
Jian Zhang +6 more
doaj +1 more source
Processing of bacterial RNA [PDF]
FEBS Letters, 1981 Processing of RNA is a feature of RNA metabolism which contributes to the determination of the fmal population of active RNA molecules in the cell. Pro- cessing is the sum of events which converts a primary RNA transcript into a functional molecule. RNA processing in bacteria consists mainly of two parts, modification of nucleotides and cutting and ...
Apirion, David, Gegenheimer, Peter
openaire +2 more sources
RNA-binding protein CPEB1 remodels host and viral RNA landscapes. [PDF]
, 2016 Host and virus interactions occurring at the post-transcriptional level are critical for infection but remain poorly understood. Here, we performed comprehensive transcriptome-wide analyses revealing that human cytomegalovirus (HCMV) infection results in
Aigner, Stefan +17 more
core +2 more sources
RNA Processing Marches on [PDF]
Cell, 2000 We would like to thank the many colleagues who contributed unpublished data and helpful comments. We apologize to those whose work could not be fully referenced due to space limitations. D. T. was supported by the Wellcome Trust. J. F. C. was supported by the MRC.
Tollervey, David, Caceres, Javier F
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Salmonella produce microRNA-like RNA fragment Sal-1 in the infected cells to facilitate intracellular survival. [PDF]
, 2017 Salmonella have developed a sophisticated machinery to evade immune clearance and promote survival in the infected cells. Previous studies were mostly focused on either bacteria itself or host cells, the interaction mechanism of host-pathogen awaits ...
Chen, Xi +11 more
core +2 more sources
Telomere maintenance: regulating hTERC fate through RNA modifications
Molecular & Cellular Oncology, 2019 Disturbances in telomere maintenance are common in cancer. We recently showed that Single-strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1) promotes telomere homeostasis by regulating the stability of the telomeric RNA component (hTERC ...
Lisa Lirussi, Hilde Nilsen
doaj +1 more source
, 2019 RNAs can be either transcribed directly as functional species or as molecules that require post-transcriptional processing by ribonucleases. Most messenger RNAs fall into the first category, while most structural RNAs fall into the second. There are, however, some specific examples of mRNAs that undergo processing to shorter, more stable species with a
Braun, Frederique, Condon, Ciaran
openaire +1 more source
Components required for in vitro cleavage and polyadenylation of eukaryotic mRNA [PDF]
, 1988 We have studied in vitro cleavage/polyadenylation of precursor RNA containing herpes simplex virus type 2 poly A site sequences and have analysed four RNA/protein complexes which form during in vitro reactions.
Clements, J.B. +3 more
core +1 more source
Heat shock-induced phosphorylation of TAR DNA-binding protein 43 (TDP-43) by MAPK/ERK kinase regulates TDP-43 function [PDF]
, 2017 TAR DNA-binding protein (TDP-43) is a highly conserved and essential DNA- and RNA-binding protein that controls gene expression through RNA processing, in particular, regulation of splicing.
Ayala, Yuna M +8 more
core +2 more sources