Results 31 to 40 of about 938,495 (334)

Phosphoproteomics Screen Reveals Akt Isoform-Specific Signals Linking RNA Processing to Lung Cancer [PDF]

, 2014
The three Akt isoforms are functionally distinct. Here we show that their phosphoproteomes also differ, suggesting that their functional differences are due to differences in target specificity.
Ailan Guo, Bild, Cai, Carstens, Carvalho, Chen, Chen, Cho, Christos Polytarchou, Conrad, Cooper, Dimitrios Iliopoulos, Duina, Ezell, Filippos Kottakis, Franke, Gowher, Iliopoulos, Ioannis Sanidas, Jianxin Xie, Kalsotra, Kolasinska-Zwierz, Kottakis, Krogan, Kumar, Lan Hu, Luco, Luco, Manning, Maria Hatziapostolou, Maroulakou, Michael J. Comb, Miki, Moore, Moshkin, Orr-Urtreger, Peña, Philip N. Tsichlis, Polytarchou, Scott A. Ezell, Thiery, Tschopp, Wan, Wang, Warzecha, Xie, Yoh, Yoh, Zhang, Zhou   +49 more
core   +1 more source

GRSF1 Regulates RNA Processing in Mitochondrial RNA Granules [PDF]

Cell Metabolism, 2013
Various specialized domains have been described in the cytosol and the nucleus; however, little is known about compartmentalization within the mitochondrial matrix. GRSF1 (G-rich sequence factor 1) is an RNA binding protein that was previously reported to localize in the cytosol.
Jourdain AA, Koppen M, Wydro M, Rodley CD, Lightowlers RN, Chrzanowska-Lightowlers ZM, Martinou JC   +6 more
openaire   +5 more sources

Plant Ribonuclease J: An Essential Player in Maintaining Chloroplast RNA Quality Control for Gene Expression

Plants, 2020
RNA quality control is an indispensable but poorly understood process that enables organisms to distinguish functional RNAs from nonfunctional or inhibitory ones.
Amber M. Hotto, David B. Stern, Gadi Schuster   +2 more
doaj   +1 more source

Structural insights into RNA processing by the human RISC-loading complex. [PDF]

, 2009
Targeted gene silencing by RNA interference (RNAi) requires loading of a short guide RNA (small interfering RNA (siRNA) or microRNA (miRNA)) onto an Argonaute protein to form the functional center of an RNA-induced silencing complex (RISC).
AD Haase, B Kastner, Bunpote Siridechadilok, C Matranga, Cameron Noland, David W Taylor, DS Schwarz, E Bernstein, E Ma, EF Pettersen, Enbo Ma, Eva Nogales, F Herzog, FV Rivas, H Gao, Hong-Wei Wang, IJ MacRae, IJ MacRae, IJ MacRae, JB Preall, Jennifer A Doudna, JJ Song, Karin Felderer, KH Kok, M Högbom, M Radermacher, M van Heel, PA Penczek, SH Scheres, SJ Ludtke, T Sasaki, TA Rand, TM Rana, TP Chendrimada, W Wriggers, Y Lee, Y Tomari, Y Tomari, Y Wang, Y Wang, YR Yuan, YR Yuan   +41 more
core   +5 more sources

Components required for in vitro cleavage and polyadenylation of eukaryotic mRNA [PDF]

, 1988
We have studied in vitro cleavage/polyadenylation of precursor RNA containing herpes simplex virus type 2 poly A site sequences and have analysed four RNA/protein complexes which form during in vitro reactions.
Clements, J.B., McLauchlan, J., Moore, C.L., Simpson, S.   +3 more
core   +1 more source

CDK12 Activity-Dependent Phosphorylation Events in Human Cells

Biomolecules, 2019
We asked whether the C-terminal repeat domain (CTD) kinase, CDK12/CyclinK, phosphorylates substrates in addition to the CTD of RPB1, using our CDK12analog-sensitive HeLa cell line to investigate CDK12 activity-dependent phosphorylation events in human ...
Bartlomiej Bartkowiak, Christopher M. Yan, Erik J. Soderblom, Arno L. Greenleaf   +3 more
doaj   +1 more source

ReadZS detects cell type-specific and developmentally regulated RNA processing programs in single-cell RNA-seq

Genome Biology, 2022
RNA processing, including splicing and alternative polyadenylation, is crucial to gene function and regulation, but methods to detect RNA processing from single-cell RNA sequencing data are limited by reliance on pre-existing annotations, peak calling ...
Elisabeth Meyer, Kaitlin Chaung, Roozbeh Dehghannasiri, Julia Salzman   +3 more
doaj   +1 more source

Population and allelic variation of A-to-I RNA editing in human transcriptomes. [PDF]

, 2017
BackgroundA-to-I RNA editing is an important step in RNA processing in which specific adenosines in some RNA molecules are post-transcriptionally modified to inosines.
Demirdjian, Levon, Guo, Jiguang, Lin, Lan, Park, Eddie, Shen, Shihao, Wu, Ying Nian, Xing, Yi   +6 more
core   +2 more sources

Uridylation and adenylation of RNAs. [PDF]

, 2015
The posttranscriptional addition of nontemplated nucleotides to the 3' ends of RNA molecules can have a significant impact on their stability and biological function.
Chen, XueMei, Mo, BeiXin, Song, JianBo, Song, Jun   +3 more
core   +2 more sources

The RNA-binding protein ELAV regulates Hox RNA processing, expression and function within the Drosophila nervous system [PDF]

, 2014
The regulated head-to-tail expression of Hox genes provides a coordinate system for the activation of specific programmes of cell differentiation according to axial level.
Akam, Alonso, Alonso, Alonso, Alonso, Arendt, Artero, Bardet, Beckervordersandforth, Bomze, Brudno, Cairrao, Custodio, Custodio, de la Mata, de Navas, Di Giammartino, Dittrich, Good, Halter, Hatton, Hilgers, Irvine, Kornfeld, Koushika, Licatalosi, Lisbin, Lopez, Lumsden, Lumsden, López de Silanes, Mallo, Mann, McGinnis, Miguel-Aliaga, O'Connor, Patraquim, Philippidou, Proudfoot, Reed, Reichert, Robinow, Robinow, Robinow, Rogulja-Ortmann, Schindelin, Schwartz, Shimell, Simon, Simone, Soller, Soller, Subramaniam, Sánchez-Herrero, Thomsen, Thor, Wang, Yao   +57 more
core   +1 more source