Results 41 to 50 of about 955,921 (334)
The Crosstalk Between Epigenetic Mechanisms and Alternative RNA Processing Regulation
Frontiers in Genetics, 2020 As a co-transcriptional process, RNA processing, including alternative splicing and alternative polyadenylation, is crucial for the generation of multiple mRNA isoforms.
Jian Zhang +6 more
doaj +1 more source
Uridylation and adenylation of RNAs. [PDF]
, 2015 The posttranscriptional addition of nontemplated nucleotides to the 3' ends of RNA molecules can have a significant impact on their stability and biological function.
Chen, XueMei +3 more
core +2 more sources
Comparability of Microarray Data between Amplified and Non Amplified RNA in Colorectal Carcinoma [PDF]
, 2009 Microarray analysis reaches increasing popularity during the investigation of prognostic gene clusters in oncology. The standardisation of technical procedures will be essential to compare various datasets produced by different research groups.
Brueckl, WM +10 more
core +4 more sources
RNA regulation of epigenetic processes [PDF]
BioEssays, 2009 AbstractThere is increasing evidence that dynamic changes to chromatin, chromosomes and nuclear architecture are regulated by RNA signalling. Although the precise molecular mechanisms are not well understood, they appear to involve the differential recruitment of a hierarchy of generic chromatin modifying complexes and DNA methyltransferases to ...
Mattick, J. S +4 more
openaire +4 more sources
CDK12 Activity-Dependent Phosphorylation Events in Human Cells
Biomolecules, 2019 We asked whether the C-terminal repeat domain (CTD) kinase, CDK12/CyclinK, phosphorylates substrates in addition to the CTD of RPB1, using our CDK12analog-sensitive HeLa cell line to investigate CDK12 activity-dependent phosphorylation events in human ...
Bartlomiej Bartkowiak +3 more
doaj +1 more source
In vivo nuclear RNA structurome reveals RNA-structure regulation of mRNA processing in plants
Genome Biology, 2021 Background mRNA processing is critical for gene expression. A challenge in regulating mRNA processing is how to recognize the actual mRNA processing sites, such as splice and polyadenylation sites, when the sequence content is insufficient for this ...
Zhenshan Liu +8 more
doaj +1 more source
The RNA-binding protein ELAV regulates Hox RNA processing, expression and function within the Drosophila nervous system [PDF]
, 2014 The regulated head-to-tail expression of Hox genes provides a coordinate system for the activation of specific programmes of cell differentiation according to axial level.
Akam +57 more
core +1 more source
Enzymatic Processing of Platinated RNAs [PDF]
Journal of the American Chemical Society, 2010 The broadly prescribed antitumor drug cisplatin coordinates to DNA, altering the activity of cellular proteins whose functions rely upon sensing DNA structure. Cisplatin is also known to coordinate to RNA, but the effects of RNA-Pt adducts on the large number of proteins that process the transcriptome are currently unknown.
Erich G. Chapman, Victoria J. DeRose
openaire +3 more sources
Mitochondrial RNA processing in trypanosomes [PDF]
Research in Microbiology, 2011 The mitochondrial genome of trypanosomes is composed of ∼50 maxicircles and thousands of minicircles. Maxi-(∼25 kb) and mini-(∼1 kb)circles are catenated and packed into a dense structure called a kinetoplast. Both types of circular DNA are transcribed by a phage-like RNA polymerase: maxicircles yield multicistronic rRNA and mRNA precursors, while ...
Ruslan Aphasizhev, Inna Aphasizheva
openaire +3 more sources
Mechanistic insights into non-coding Y RNA processing
RNA Biology, 2022 Y RNAs (84–112 nt) are non-coding RNAs transcribed by RNA polymerase III and are characterized by a distinctive secondary structure. Human Y RNAs interact with the autoimmune proteins SSB and RO60 that together form a ribonucleoprotein (RNP) complex ...
Martina Billmeier +7 more
doaj +1 more source