Results 51 to 60 of about 938,495 (334)
Can we always sweep the details of RNA-processing under the carpet?
, 2013 RNA molecules follow a succession of enzyme-mediated processing steps from transcription until maturation. The participating enzymes, for example the spliceosome for mRNAs and Drosha and Dicer for microRNAs, are also produced in the cell and their copy ...
Berg, Johannes +2 more
core +1 more source
RNA processing: Pocket guides to ribosomal RNA [PDF]
Current Biology, 1997 The functional role of a recently identified class of small nucleolar (sno) RNAs has been elucidated: the 'box H/ACA' snoRNAs act as guide RNAs, specifying the position of evolutionarily conserved pseudouridines in ribosomal (r)RNA via an rRNA-snoRNA base-pairing interaction that forms a 'pseudouridine pocket'.
openaire +3 more sources
Identification of human mitochondrial RNA cleavage sites and candidate RNA processing factors
BMC Biology, 2022 Background The human mitochondrial genome is transcribed as long strands of RNA containing multiple genes, which require post-transcriptional cleavage and processing to release functional gene products that play vital roles in cellular energy production.
Guillermo Carbajosa +2 more
doaj +1 more source
DICER-LIKE2 plays a primary role in transitive silencing of transgenes in Arabidopsis. [PDF]
, 2008 Dicer-like (DCL) enzymes play a pivotal role in RNA silencing in plants, processing the long double-stranded RNA (dsRNA) that triggers silencing into the primary short interfering RNAs (siRNAs) that mediate it.
Bowman, Lewis H +8 more
core +5 more sources
Mitochondrial RNA processing in trypanosomes [PDF]
Research in Microbiology, 2011 The mitochondrial genome of trypanosomes is composed of ∼50 maxicircles and thousands of minicircles. Maxi-(∼25 kb) and mini-(∼1 kb)circles are catenated and packed into a dense structure called a kinetoplast. Both types of circular DNA are transcribed by a phage-like RNA polymerase: maxicircles yield multicistronic rRNA and mRNA precursors, while ...
Ruslan Aphasizhev, Inna Aphasizheva
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Nature Communications, 2023 Transcription by RNA polymerase I (RNAPI) represents most of the transcriptional activity in eukaryotic cells and is associated with the production of mature ribosomal RNA (rRNA).
Maxime Duval +5 more
doaj +1 more source
RNA regulatory processes in RNA virus biology
WIREs RNA, 2019 AbstractNumerous post‐transcriptional RNA processes play a major role in regulating the quantity, quality and diversity of gene expression in the cell. These include RNA processing events such as capping, splicing, polyadenylation and modification, but also aspects such as RNA localization, decay, translation, and non‐coding RNA‐associated regulation ...
Shaun T. Cross +3 more
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Gene induction during differentiation of human monocytes into dendritic cells: an integrated study at the RNA and protein levels [PDF]
, 2001 Changes in gene expression occurring during differentiation of human monocytes into dendritic cells were studied at the RNA and protein levels. These studies showed the induction of several gene classes corresponding to various biological functions ...
Angénieux, C. +9 more
core +3 more sources
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source
Genome-wide Mapping of 5′-monophosphorylated Ends of Mammalian Nascent RNA Transcripts
Bio-Protocol, 2023 In eukaryotic cells, RNA biogenesis generally requires processing of the nascent transcript as it is being synthesized by RNA polymerase. These processing events include endonucleolytic cleavage, exonucleolytic trimming, and splicing of the growing ...
Michael Cortázar +2 more
doaj +1 more source