Results 1 to 10 of about 1,457,875 (185)

RNA Sequencing in Schizophrenia [PDF]

Bioinformatics and Biology Insights, 2015
Schizophrenia (SCZ) is a serious psychiatric disorder that affects 1% of general population and places a heavy burden worldwide. The underlying genetic mechanism of SCZ remains unknown, but studies indicate that the disease is associated with a global ...
Xin Li, Shaolei Teng
doaj   +4 more sources

HCC: RNA-Sequencing in Cirrhosis

Biomolecules, 2023
Hepatocellular carcinoma (HCC) ranks the most common types of cancer worldwide. As the fourth leading cause of cancer-related deaths, its prognosis remains poor. Most patients developed HCC on the basis of chronic liver disease. Cirrhosis is an important
Haoyu Wang, Wenjie Shi, Jing Lu, Yuan Liu, Wei Zhou, Zekun Yu, Shengying Qin, Junwei Fan   +7 more
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A gene-specific RNA enrichment protocol for nanopore direct-RNA sequencing. [PDF]

PLoS ONE
Oxford Nanopore direct-RNA sequencing, a third-generation sequencing technology, allows for the analysis of native RNA molecules in their natural cellular state.
Maja Bele Dyrendalsli, Cecilie Løkke, Christer Einvik   +2 more
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Quantification of substoichiometric modification reveals global tsRNA hypomodification, preferences for angiogenin-mediated tRNA cleavage, and idiosyncratic epitranscriptomes of human neuronal cell-lines

Computational and Structural Biotechnology Journal, 2023
Modification of tRNA is an integral part of the epitranscriptome with a particularly pronounced potential to generate diversity in RNA expression. Eukaryotic tRNA contains modifications in up to 20% of their nucleotides, but not all sites are always ...
Florian Pichot, Marion C. Hogg, Virginie Marchand, Valérie Bourguignon, Elisabeth Jirström, Cliona Farrell, Hesham A. Gibriel, Jochen H.M. Prehn, Yuri Motorin, Mark Helm   +9 more
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Direct RNA sequencing [PDF]

Nature, 2009
Our understanding of human biology and disease is ultimately dependent on a complete understanding of the genome and its functions. The recent application of microarray and sequencing technologies to transcriptomics has changed the simplistic view of transcriptomes to a more complicated view of genome-wide transcription where a large fraction of ...
Fatih, Ozsolak, Adam R, Platt, Dan R, Jones, Jeffrey G, Reifenberger, Lauryn E, Sass, Peter, McInerney, John F, Thompson, Jayson, Bowers, Mirna, Jarosz, Patrice M, Milos   +9 more
openaire   +3 more sources

Holistic Optimization of Bioinformatic Analysis Pipeline for Detection and Quantification of 2′-O-Methylations in RNA by RiboMethSeq

Frontiers in Genetics, 2020
A major trend in the epitranscriptomics field over the last 5 years has been the high-throughput analysis of RNA modifications by a combination of specific chemical treatment(s), followed by library preparation and deep sequencing.
Florian Pichot, Florian Pichot, Florian Pichot, Virginie Marchand, Lilia Ayadi, Lilia Ayadi, Valérie Bourguignon-Igel, Valérie Bourguignon-Igel, Mark Helm, Yuri Motorin, Yuri Motorin   +10 more
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Advances in Non-Coding RNA Sequencing

Non-Coding RNA, 2021
Non-coding RNAs (ncRNAs) comprise a set of abundant and functionally diverse RNA molecules. Since the discovery of the first ncRNA in the 1960s, ncRNAs have been shown to be involved in nearly all steps of the central dogma of molecular biology.
Julia Micheel, Aram Safrastyan, Damian Wollny   +2 more
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On the utility of RNA sample pooling to optimize cost and statistical power in RNA sequencing experiments [PDF]

, 2020
Background: In gene expression studies, RNA sample pooling is sometimes considered because of budget constraints or lack of sufficient input material. Using microarray technology, RNA sample pooling strategies have been reported to optimize both the cost
Assefa, Alemu Takele, Thas, Olivier, Vandesompele, Jo   +2 more
core   +2 more sources

From bulk, single-cell to spatial RNA sequencing

International Journal of Oral Science, 2021
RNA sequencing (RNAseq) can reveal gene fusions, splicing variants, mutations/indels in addition to differential gene expression, thus providing a more complete genetic picture than DNA sequencing.
Xinmin Li, Cun-Yu Wang
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Utility of nanopore sequencing for detecting pathogens in bronchoalveolar lavage fluid from pediatric patients with respiratory failure

Journal of Clinical Virology Plus, 2023
RNA viruses are the most frequent pathogens responsible for respiratory infections, particularly in pediatric patients. Next-generation sequencing, represented by Illumina sequencing, is one of the most comprehensive methods for identifying pathogens ...
Makoto Yamaguchi, Kazuhiro Horiba, Kazunori Haruta, Suguru Takeuchi, Takako Suzuki, Yuka Torii, Shinji Kawabe, Sho Wada, Takanari Ikeyama, Yoshinori Ito, Tomoo Ogi, Jun-ichi Kawada   +11 more
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