Results 241 to 250 of about 1,457,994 (304)

Advances and challenges in single-cell RNA sequencing data analysis: a comprehensive review. [PDF]

Brief Bioinform
Nesari AM, MotieGhader H, Ghorbian S.
europepmc   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Identification of potential characteristic genes in sepsis utilizing RNA sequencing and gene silence. [PDF]

BMC Immunol
Cao H, Qin N, Zhai Y, Dong C, Huang Z, Huang D, Li J, Yang J, Wang F, Wei W, Wang W.   +10 more
europepmc   +1 more source

Analysis of the potential regulatory mechanism of PIEZO1 in Alzheimer's disease based on RNA sequencing. [PDF]

IBRO Neurosci Rep
Wang YH, Xie Y, Ding PL, Ge JW, Xie L, Wu DH, Xin C.   +6 more
europepmc   +1 more source

Opportunities for RNA sequencing in physiology: from big data to understanding homeostasis and heterogeneity. [PDF]

Function (Oxf)
Prokop JW, Bilinovich SM, Tokarski E, Vishweswaraiah S, VanderWeele S, Das AS, Chhetri SB, Dao A, Arora S, Goodyke A, Buelow KL, Westgate M, VanSickle EA, Edell CJ, Benson LN, Campbell DB, Bupp CP, Holsworth A, Hartog NL, Krueger JM, Cordoba M, Sims M, Tamae Kakazu MA, Peraino AM, Graham SF, Triche T, Hussain E, Leimanis-Laurens ML, Krawczyk CM, Pollock JS, Rajasekaran S.   +30 more
europepmc   +1 more source

Commentary: a review of technical considerations for planning an RNA-Sequencing experiment. [PDF]

BMC Genomics
Verma R, Savaria-Butler A, Enguita FJ, Meller R.   +3 more
europepmc   +1 more source

Prognostic model for predicting recurrence-free survival in hepatocellular carcinoma using integrated analysis of single-cell RNA-sequencing and bulk RNA-sequencing. [PDF]

Oncol Lett
Yang W, Lai W, Hu Q, Ma J, Liu H, Li Z, Li Q, Guo X, Zhong L.   +8 more
europepmc   +1 more source

Altered Microglia-Neuron Crosstalk and Regional Heterogeneity in Alzheimer's Disease Revealed by Single-Nucleus RNA Sequencing. [PDF]

Int J Mol Sci
Yang Z, Zhang M, Zhi W, Ma L, Hu X, Zou Y, Wang L.   +6 more
europepmc   +1 more source