Results 11 to 20 of about 156,310 (280)
RNA-Binding Proteins: Splicing Factors and Disease [PDF]
Biomolecules, 2015 Pre-mRNA splicing is mediated by interactions of the Core Spliceosome and an array of accessory RNA binding proteins with cis-sequence elements. Splicing is a major regulatory component in higher eukaryotes.
Alger M. Fredericks +3 more
doaj +3 more sources
RNA splicing factors as oncoproteins and tumour suppressors. [PDF]
Nat Rev Cancer, 2016 The recent genomic characterization of cancers has revealed recurrent somatic point mutations and copy number changes affecting genes encoding RNA splicing factors. Initial studies of these 'spliceosomal mutations' suggest that the proteins bearing these mutations exhibit altered splice site and/or exon recognition preferences relative to their wild ...
Dvinge H +3 more
europepmc +5 more sources
The DEAH-box splicing factor Prp16 unwinds RNA duplexes in vitro [PDF]
Current Biology, 1998 During pre-mRNA splicing, dynamic rearrangement of RNA secondary structure within the spliceosome is crucial for intron recognition and formation of the catalytic core. Splicing factors belonging to the DExD/DExH-box family of RNA-dependent ATPases are thought to have a central role in directing these rearrangements by unwinding RNA helices.
Yan Wang +2 more
openalex +3 more sources
Identifying RNA splicing factors using IFT genes in Chlamydomonas reinhardtii. [PDF]
Open Biol, 2018 Intraflagellar transport moves proteins in and out of flagella/cilia and it is essential for the assembly of these organelles. Using whole-genome sequencing, we identified splice site mutations in two IFT genes, IFT81 ( fla9 ) and IFT121 (
Lin H, Zhang Z, Iomini C, Dutcher SK.
europepmc +6 more sources
The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation [PDF]
The EMBO Journal, 1999 The cellular protein p32 was isolated originally as a protein tightly associated with the essential splicing factor ASF/SF2 during its purification from HeLa cells. ASF/SF2 is a member of the SR family of splicing factors, which stimulate constitutive splicing and regulate alternative RNA splicing in a positive or negative fashion, depending on where ...
Svend K. Petersen‐Mahrt +5 more
openalex +4 more sources
AKAP95 regulates splicing through scaffolding RNAs and RNA processing factors [PDF]
Nature Communications, 2016 AbstractAlternative splicing of pre-mRNAs significantly contributes to the complexity of gene expression in higher organisms, but the regulation of the splice site selection remains incompletely understood. We have previously demonstrated that a chromatin-associated protein, AKAP95, has a remarkable activity in enhancing chromatin transcription.
Hu, J. +7 more
openaire +4 more sources
RNA-splicing factor SART3 regulates translesion DNA synthesis [PDF]
Nucleic Acids Research, 2018 Translesion DNA synthesis (TLS) is one mode of DNA damage tolerance that uses specialized DNA polymerases to replicate damaged DNA. DNA polymerase η (Polη) is well known to facilitate TLS across ultraviolet (UV) irradiation and mutations in POLH are implicated in skin carcinogenesis.
Min Huang +14 more
openaire +2 more sources
Nuclearly Encoded Splicing Factors Implicated in RNA Splicing in Higher Plant Organelles [PDF]
Molecular Plant, 2010 Plant organelles arose from two independent endosymbiosis events. Throughout evolutionary history, tight control of chloroplasts and mitochondria has been gained by the nucleus, which regulates most steps of organelle genome expression and metabolism.
de Longevialle, Andéol Falcon +2 more
openaire +2 more sources
The nexus of long noncoding RNAs, splicing factors, alternative splicing and their modulations
RNA Biology, 2023 The process of alternative splicing (AS) is widely deregulated in a variety of cancers. Splicing is dependent upon splicing factors. Recently, several long noncoding RNAs (lncRNAs) have been shown to regulate AS by directly/indirectly interacting with splicing factors.
Pushkar Malakar +4 more
openaire +3 more sources
SFMetaDB: a comprehensive annotation of mouse RNA splicing factor RNA-Seq datasets [PDF]
Database, 2017 AbstractAlthough the number of RNA-Seq datasets deposited publicly has increased over the past few years, incomplete annotation of the associated metadata limits their potential use. Because of the importance of RNA splicing in diseases and biological processes, we constructed a database called SFMetaDB by curating datasets related with RNA splicing ...
Li J +7 more
openaire +2 more sources