Results 251 to 260 of about 156,310 (280)

circNR3C2 promotes chondrogenic differentiation and cartilage repair of human adipose‐derived stem cells via the hsa‐miR‐647/SOX9 pathway

Animal Models and Experimental Medicine, EarlyView.
The hypothesis diagram illustrates the function and mechanism of circNR3C2: circNR3C2 overexpression can up‐regulate COL2, Aggrecan and SOX9 expression, and regulate chondrogenic differentiation of hADSCs by targeting hsa‐miR‐647. Abstract Background Human adipose‐derived stem cells (hADSCs) are seed cells with application prospects in cartilage repair.
Dabiao Hou, Huajun Wang, Hao Guo, Dongbin Luo, Xiaofei Zheng, Simin Luo   +5 more
wiley   +1 more source

Improvement of Diagnostics in NSCLC Patients with <i>MET</i> Exon 14 Mutations Using Complementary DNA/RNA-NGS and Identification of Two Novel Exonic Splicing Mutations. [PDF]

Int J Mol Sci
Urbanska EM, Doktor TK, Melchior LC, Petersson ES, Sørensen JB, Santoni-Rugiu E, Andresen BS, Grauslund M.   +7 more
europepmc   +1 more source

Insights into organelle forming RNAs: Diversity, functions and future perspectives

Animal Models and Experimental Medicine, EarlyView.
RNA molecules play crucial roles in the formation and maintenance of cellular structures and organelles. These ‘organelle formation RNAs’ include ribosomal RNAs, paraspeckle‐forming RNAs, nuclear speckle‐forming RNAs, nucleolus‐forming RNAs, and cytoskeleton‐forming RNA.
Meng Gong, Xiangting Wang, Xiaolin Liang
wiley   +1 more source

Regulation of CLK1 Isoform Expression by Alternative Splicing in Activated Human Monocytes Contributes to Activation-Associated TNF Production. [PDF]

Cells
van Haaren MJH, Bodelón A, Sijbers LJPM, Scholman R, Picavet LW, Calis JJA, Vastert SJ, van Loosdregt J.   +7 more
europepmc   +1 more source

TARDBP (TDP‐43) Knock‐in Zebrafish Display a Late‐Onset Motor Phenotype and Loss of Large Spinal Cord Motor Neurons

Annals of Neurology, EarlyView.
Objective Mutations in TARDBP (encoding TDP‐43) are associated with the neurodegenerative disease amyotrophic lateral sclerosis (ALS) and include familial missense mutations where there are a lack of models and mechanisms examining how they are pathogenic.
Ziyaan A. Harji, Christian J. Rampal, Esteban C. Rodríguez, Virginie Petel Légaré, Alexandra Lissouba, Sabrina Semmler, Meijiang Liao, Jay P. Ross, Guy A. Rouleau, Christine Vande Velde, Gary A.B. Armstrong   +10 more
wiley   +1 more source

Age-related aberrant alternative splicing as a prognostic tool in older breast cancer patients. [PDF]

Commun Biol
Chen M, Xiao T, Ke H, Ye C, Yu F, Su J, Yang S, Feng Y, Xu H, Fu S, Lin L, Lin J, Xie Y, Ding Q, Qiu Y, Yu R, Lv H, Li W, Zhang Y, Ding Z, Zou Y, Yuan H, Zhao L.   +22 more
europepmc   +1 more source

Synergistic intragenic epigenetic deregulation by IDH2 and SRSF2 mutations causes mis-splicing of key transcriptional regulators. [PDF]

Sci Adv
Telonis AG, Stanley RF, Adelman ER, Yoshimi A, Adele AA, Cruz A, Wiseman DH, Abdel-Wahab O, Figueroa ME.   +8 more
europepmc   +1 more source

A therapeutic antisense oligonucleotide encompassing 2'-<i>O</i>-methoxyethyl modification triggers unique perturbation of the transcriptome. [PDF]

NAR Mol Med
Ottesen EW, Murzyn WA, Kaas RL, Bertrand KJ, Payne JL, Singh RN.   +5 more
europepmc   +1 more source

Long non-coding RNA AFAP1-AS1 promotes alternative splicing of AXIN2 by facilitating SRSFs phase separation to induce drug resistance in lung adenocarcinoma. [PDF]

Mol Cancer
Ouyang J, Zhang Y, Hou X, Xiong F, Shi L, Zhong Y, Yang L, Guo C, Zeng Z, Yan Q, Chen P, Xiong W.   +11 more
europepmc   +1 more source