Results 21 to 30 of about 156,310 (280)

Colocalization of intranuclear lamin foci with RNA splicing factors [PDF]

Journal of Cell Science, 1999
ABSTRACT The lamins form a fibrous network underlying the inner nuclear membrane termed the nuclear lamina. In order to gain insights into the role of lamins in nuclear organization, we have characterized a monoclonal antibody (LA-2H10) raised against recombinant rat lamin A that labels nuclei in a speckled pattern in all cells of ...
Jagatheesan, G, Thanumalayan, S, Muralikrishna, Bh, Rangaraj, Nandini, Karande, Anjali A, Parnaik, Veena K   +5 more
openaire   +3 more sources

SCR106 splicing factor modulates abiotic stress responses by maintaining RNA splicing in rice

Journal of Experimental Botany, 2023
Abstract Plants employ sophisticated molecular machinery to fine-tune their responses to growth, developmental, and stress cues. Gene expression influences plant cellular responses through regulatory processes such as transcription and splicing.
Abdulrahman Alhabsi, Haroon Butt, Gwendolyn K Kirschner, Ikram Blilou, Magdy M Mahfouz   +4 more
openaire   +3 more sources

L4-33K, an Adenovirus-encoded Alternative RNA Splicing Factor [PDF]

Journal of Biological Chemistry, 2006
Splicing of the adenovirus IIIa mRNA is subjected to a strict temporal regulation during virus infection such that efficient IIIa 3' splice site usage is confined to the late phase of the infectious cycle. Here we show that the adenovirus L4-33K protein functions as a virus-encoded RNA splicing factor that preferentially activates splicing of ...
Heidi, Törmänen, Ellenor, Backström, Anette, Carlsson, Göran, Akusjärvi   +3 more
openaire   +2 more sources

Investigation of androgen receptor-dependent alternative splicing has identified a unique subtype of lethal prostate cancer

Asian Journal of Andrology, 2023
A complete proteomics study characterizing active androgen receptor (AR) complexes in prostate cancer (PCa) cells identified a diversity of protein interactors with tumorigenic annotations, including known RNA splicing factors.
Sean Seltzer, Paresa N Giannopoulos, Tarek A Bismar, Mark Trifiro, Miltiadis Paliouras   +4 more
doaj   +1 more source

Structural basis of UCUU RNA motif recognition by splicing factor RBM20 [PDF]

Nucleic Acids Research, 2020
ABSTRACTThe vertebrate splicing factor RBM20 (RNA Binding Motif protein 20) regulates protein isoforms important for heart development and function, with mutations in the gene linked to cardiomyopathy. Previous studies have identified the four base RNA motif UCUU as a common element in pre-mRNA targeted by RBM20.
Santosh Kumar Upadhyay, Cameron D. Mackereth   +1 more
openalex   +4 more sources

The Interplay Between the DNA Damage Response, RNA Processing and Extracellular Vesicles

Frontiers in Oncology, 2020
RNA processing was recently found to affect DNA damage response. The RNA processing factors THRAP3 and BCLAF1 play critical role in keeping DNA genomic stability by regulating the transcription, mRNA splicing and export of DNA repair proteins BRCA2 ...
Xiangbing Meng, Xiangbing Meng, Shujie Yang, Shujie Yang, Vanessa J. A. Camp   +4 more
doaj   +1 more source

Pre-mRNA Processing Factors and Retinitis Pigmentosa: RNA Splicing and Beyond [PDF]

Frontiers in Cell and Developmental Biology, 2021
Retinitis pigmentosa (RP) is the most common inherited retinal disease characterized by progressive degeneration of photoreceptors and/or retinal pigment epithelium that eventually results in blindness. Mutations in pre-mRNA processing factors (PRPF3, 4, 6, 8, 31, SNRNP200, and RP9) have been linked to 15–20% of autosomal dominant RP (adRP) cases ...
Chunbo Yang, Maria Georgiou, Robert Atkinson, Joseph Collin, Jumana Al-Aama, Sushma Nagaraja-Grellscheid, Colin Johnson, Robin Ali, Lyle Armstrong, Sina Mozaffari-Jovin, Sina Mozaffari-Jovin, Sina Mozaffari-Jovin, Majlinda Lako   +12 more
openaire   +6 more sources

Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes [PDF]

Oncogene, 2015
Alternative splicing is a widespread process contributing to structural transcript variation and proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both functional and non-functional end-products. Cancer-specific splicing events are known to contribute to disease progression; however, the dysregulated splicing ...
A, Sveen, S, Kilpinen, A, Ruusulehto, R A, Lothe, R I, Skotheim   +4 more
openaire   +2 more sources

An intronic RNA element modulates Factor VIII exon-16 splicing

Nucleic Acids Research, 2023
Abstract Pathogenic variants in the human Factor VIII (F8) gene cause Hemophilia A (HA). Here, we investigated the impact of 97 HA-causing single-nucleotide variants on the splicing of 11 exons from F8. For the majority of F8 exons, splicing was insensitive to the presence of HA-causing variants.
Victor Tse, Guillermo Chacaltana, Martin Gutierrez, Nicholas M Forino, Arcelia G Jimenez, Hanzhang Tao, Phong H Do, Catherine Oh, Priyanka Chary, Isabel Quesada, Antonia Hamrick, Sophie Lee, Michael D Stone, Jeremy R Sanford   +13 more
openaire   +4 more sources

Splicing Factors Have an Essential Role in Prostate Cancer Progression and Androgen Receptor Signaling

Biomolecules, 2019
Although inhibition of the androgen–androgen receptor (AR) axis effectively represses the growth of prostate cancer, most of all cases eventually become castration-resistant prostate cancers (CRPCs).
Ken-ichi Takayama
doaj   +1 more source