Results 41 to 50 of about 156,310 (280)

Interaction of the yeast splicing factor PRP8 with substrate RNA during both steps of splicing [PDF]

Nucleic Acids Research, 1995
PRP8 protein of Saccharomyces cerevisiae interacts directly with pre-mRNA in spliceosomes, shown previously by UV-crosslinking. To analyse at which steps of splicing and with which precursor-derived RNA species the interaction(s) take place, UV-crosslinking was combined with PRP8-specific immunoprecipitation and the coprecipitated RNA species were ...
S, Teigelkamp, E, Whittaker, J D, Beggs
openaire   +2 more sources

The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation [PDF]

Molecular Cell, 2010
Alternative splicing (AS) of pre-mRNA is utilized by higher eukaryotes to achieve increased transcriptome and proteomic complexity. The serine/arginine (SR) splicing factors regulate tissue- or cell-type-specific AS in a concentration- and phosphorylation-dependent manner.
Tripathi, Vidisha, Ellis, Jonathan D., Shen, Zhen, Song, David Y., Pan, Qun, Watt, Andrew T., Freier, Susan M., Bennett, C. Frank, Sharma, Alok, Bubulya, Paula A., Blencowe, Benjamin J., Prasanth, Supriya G., Prasanth, Kannanganattu V.   +12 more
openaire   +2 more sources

A pyrimidine-rich exonic splicing suppressor binds multiple RNA splicing factors and inhibits spliceosome assembly [PDF]

Proceedings of the National Academy of Sciences, 1998
The bovine papillomavirus type 1 (BPV-1) exonic splicing suppressor (ESS) is juxtaposed immediately downstream of BPV-1 splicing enhancer 1 and negatively modulates selection of a suboptimal 3′ splice site at nucleotide 3225. The present study demonstrates that this pyrimidine-rich ESS inhibits utilization of upstream 3′ splice sites by ...
Z M, Zheng, M, Huynen, C C, Baker
openaire   +2 more sources

Transcriptome-wide analysis of alternative RNA splicing events in Epstein-Barr virus-associated gastric carcinomas.

PLoS ONE, 2017
Multiple human diseases including cancer have been associated with a dysregulation in RNA splicing patterns. In the current study, modifications to the global RNA splicing landscape of cellular genes were investigated in the context of Epstein-Barr virus-
Victoria E S Armero, Marie-Pier Tremblay, Andréa Allaire, Simon Boudreault, Camille Martenon-Brodeur, Cyntia Duval, Mathieu Durand, Elvy Lapointe, Philippe Thibault, Maude Tremblay-Létourneau, Jean-Pierre Perreault, Michelle S Scott, Martin Bisaillon   +12 more
doaj   +1 more source

Dual function of SF3B2 on chromatin and RNA to regulate transcription in head and neck squamous cell carcinoma

Cell & Bioscience, 2022
RNA is spliced concomitantly with transcription and the process is organized by RNA splicing factors, transcriptional regulators, and chromatin regulators. RNA is spliced in close proximity to transcription machinery. Hence, some RNA splicing factors may
Koji Kitamura, Hidefumi Suzuki, Ryota Abe, Hidenori Inohara, Yasufumi Kaneda, Hidehisa Takahashi, Keisuke Nimura   +6 more
doaj   +1 more source

Nuclear Encoded RNA Splicing Factors in Plant Mitochondria [PDF]

, 2009
Mitochondria are the site of respiration and numerous other metabolic processes required for plant growth and development. Increased demands for metabolic energy are observed during different stages in the plants life cycle, but are particularly ample during germination and reproductive organ development.
Oren Ostersetzer-Biran, Alice Barkan
openaire   +1 more source

Supplementary table from Integrative RNA-omics Discovers <i>GNAS</i> Alternative Splicing as a Phenotypic Driver of Splicing Factor–Mutant Neoplasms [PDF]

, 2023
Emily C. Wheeler, Shailee Vora, Daniel Mayer, Andriana G. Kotini, Małgorzata Olszewska, Samuel S. Park, Ernesto Guccione, Julie Teruya‐Feldstein, Lewis B. Silverman, Roger K. Sunahara, G Yeo, Eirini P. Papapetrou   +11 more
  +6 more sources

TET dioxygenases localize at splicing speckles and promote RNA splicing

Nucleus
The dynamic regulation of RNA metabolism plays a crucial part in cellular function, with emerging evidence suggesting an important role for RNA modifications in this process.
Florian D. Hastert, Jasmin Weber, Christina Bauer, Andreas Zhadan, Deepanshu N. D. Singh, Thomas C. Dix, Roland Arnold, Sergey Bessonov, Matthias Soller, Heinrich Leonhardt, M. Cristina Cardoso, Maria Arroyo   +11 more
doaj   +1 more source

hnRNP A1 in RNA metabolism regulation and as a potential therapeutic target

Frontiers in Pharmacology, 2022
Abnormal RNA metabolism, regulated by various RNA binding proteins, can have functional consequences for multiple diseases. Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is an important RNA binding protein, that regulates various RNA metabolic ...
Jianguo Feng, Jianguo Feng, Jianguo Feng, Jianlong Zhou, Jianlong Zhou, Yunxiao Lin, Wenhua Huang, Wenhua Huang   +7 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source