Results 1 to 10 of about 377,639 (206)

Order and Complexity in the RNA World. [PDF]

Life (Basel), 2023
The basic idea of the RNA world as an early step towards life relies on a molecular evolution process based on self-replicating RNA strands. It is probably the oldest and most convincing model for efficient prebiotic evolution.
Mayer C.
europepmc   +2 more sources

From RNA World to SARS-CoV-2: The Edited Story of RNA Viral Evolution [PDF]

Cells, 2021
The current SARS-CoV-2 pandemic underscores the importance of understanding the evolution of RNA genomes. While RNA is subject to the formation of similar lesions as DNA, the evolutionary and physiological impacts RNA lesions have on viral genomes are ...
Kockler ZW, Gordenin DA.
europepmc   +3 more sources

RNA World with Inhibitors. [PDF]

Entropy (Basel)
During the evolution of the RNA World, compartments, which were fragments of space surrounded by a primitive lipid membrane, had to have emerged. These led eventually to the formation of modern cellular membranes.
Synak J, Rybarczyk A, Kasprzak M, Blazewicz J.   +3 more
europepmc   +2 more sources

RNA World Modeling: A Comparison of Two Complementary Approaches. [PDF]

Entropy (Basel), 2022
The origin of life remains one of the major scientific questions in modern biology. Among many hypotheses aiming to explain how life on Earth started, RNA world is probably the most extensively studied.
Synak J, Rybarczyk A, Blazewicz J.
europepmc   +2 more sources

Kin Selection in the RNA World. [PDF]

Life (Basel), 2017
Various steps in the RNA world required cooperation. Why did life’s first inhabitants, from polymerases to synthetases, cooperate? We develop kin selection models of the RNA world to answer these questions.
Levin SR, West SA.
europepmc   +2 more sources

Rethinking the tools of the RNA world. [PDF]

Elife, 2018
An artificially evolved ribozyme can catalyse the synthesis of RNA by using trinucleotide triphosphates as building blocks.
Crisp A, Carell T.
europepmc   +2 more sources

The RNA world of fungal pathogens. [PDF]

PLoS Pathog, 2023
Sankaranarayanan S, Kwon S, Heimel K, Feldbrügge M.   +3 more
europepmc   +2 more sources

The Impact of Mutant p53 in the Non-Coding RNA World. [PDF]

Biomolecules, 2020
Long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), micro RNAs (miRNAs), and extracellular RNAs (exRNAs) are new groups of RNAs with regulation activities that have low or no protein-coding ability.
Di Agostino S.
europepmc   +2 more sources

Transitioning to DNA genomes in an RNA world. [PDF]

Elife, 2017
The unexpected ability of an RNA polymerase ribozyme to copy RNA into DNA has ramifications for understanding how DNA genomes evolved.
Cojocaru R, Unrau PJ.
europepmc   +2 more sources

A novel viroid-like RNA element "Obelisks": a major breakthrough in the RNA World. [PDF]

Mol Biomed
Li L, Zhang X, Wu M.
europepmc   +2 more sources