Results 51 to 60 of about 836,536 (329)
Geographical and chronological origin and evolution of Hepatitis C Virus. [PDF]
, 2011 Hepatitis C Virus (HCV) infection is a major health problem that leads to cirrhosis and hepatocellular carcinoma. World over, more than 270-300 million people are estimated to be infected with the virus.
Achuthsankar S. Nair +2 more
core +2 more sources
Key steps from the “RNA World” to the “DNA World”
BIO Web of Conferences, 2014 In the « RNA World » hypothesis of the origin of life, RNAs are assumed to be the central macromolecules able to self-replicate, conserve information and catalyze the reactions necessary for a primitive metabolism and many enzymatic cofactors may be ...
Renard B.-L. +3 more
doaj +1 more source
Mutation of CD2AP and SH3KBP1 binding motif in alphavirus nsP3 hypervariable domain results in attenuated virus [PDF]
, 2018 Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus ...
Aquilimeba, Muriel +13 more
core +3 more sources
Reviving the RNA world: An insight into the appearance of RNA methyltransferases
Frontiers in Genetics, 2016 RNA, the earliest genetic and catalytic molecule, has a relatively delicate and labile chemical structure, when compared to DNA. It is prone to be damaged by alkali, heat, nucleases or stress conditions. One mechanism to protect RNA or DNA from damage is
Ajay Kumar Rana, Serge eAnkri
doaj +1 more source
RNA Synthesis by in Vitro Selected Ribozymes for Recreating an RNA World
Life, 2015 The RNA world hypothesis states that during an early stage of life, RNA molecules functioned as genome and as the only genome-encoded catalyst. This hypothesis is supported by several lines of evidence, one of which is the in vitro selection of catalytic
Lyssa L. Martin +2 more
doaj +1 more source
Two genetic codes: Repetitive syntax for active non-coding RNAs; non-repetitive syntax for the DNA archives [PDF]
, 2017 Current knowledge of the RNA world indicates 2 different genetic codes being present throughout the living world. In contrast to non-coding RNAs that are built of repetitive nucleotide syntax, the sequences that serve as templates for proteins share—as ...
Guenther, Witzany
core +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
The secret life of RNA and lipids
RNA BiologyThere is no life without RNA or lipids. But could there be life with only RNA and lipids? The discovery that RNA can catalyse reactions in addition to encoding information opened new directions for engineering life and the possibility of life emerging ...
Tomasz Czerniak, James P Saenz
doaj +1 more source
FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
RNA, 2015 In 1995, you could still find, in the opening paragraphs of manuscripts and grant applications from my lab and others, the phrase “In the absence of a crystal structure for the ribosome….,” by way of rationalizing any number of biochemical studies aimed at figuring out the three-dimensional locations of things inside the ribosome, and ultimately its ...
openaire +2 more sources