Results 11 to 20 of about 291,851 (290)

An alternative to the RNA World Hypothesis

Trends in Evolutionary Biology, 2011
The RNA world hypothesis for the origin of life is widely accepted in spite of the complexity of RNA synthesis. An alternative hypothesis is advanced for the origin and evolution of protein and nucleic acid synthesis. At an early stage synthesis of poly-( b -malic acid), the initial evolutionary predecessor of nucleic acids, and polypeptides was ...
Brian R. Francis
openalex   +3 more sources

A Faster Triphosphorylation Ribozyme. [PDF]

PLoS ONE, 2015
In support of the RNA world hypothesis, previous studies identified trimetaphosphate (Tmp) as a plausible energy source for RNA world organisms. In one of these studies, catalytic RNAs (ribozymes) that catalyze the triphosphorylation of RNA 5'-hydroxyl ...
Gregory F Dolan, Arvin Akoopie, Ulrich F Müller   +2 more
doaj   +10 more sources

Why Polymer Length Eliminates the RNA World. A Matter World Hypothesis for the Inevitable RNA-to-DNA Transition

The RNA World hypothesis has long served as a conceptual framework for early genetic evolution, proposing RNA as a self-sufficient informational and catalytic system preceding DNA. However, this hypothesis relies on implicit assumptions that neglect the physical consequences of polymer length.
Reza Hashemi
  +5 more sources

RNA Synthesis by in Vitro Selected Ribozymes for Recreating an RNA World

Life, 2015
The RNA world hypothesis states that during an early stage of life, RNA molecules functioned as genome and as the only genome-encoded catalyst. This hypothesis is supported by several lines of evidence, one of which is the in vitro selection of catalytic
Lyssa L. Martin, Peter J. Unrau, Ulrich F. Müller   +2 more
doaj   +3 more sources

RNA Was Never Alone? A Historical and Quantitative Reassessment of the RNA World Hypothesis(Estimated Calculating Simulation)

The RNA World Hypothesis (RWH) has dominated origin-of-life research for nearly four decades, proposing that life began with RNA acting simultaneously as genetic material and catalyst, preceding the emergence of DNA and proteins. In recent years, proponents have increasingly argued that RNA was never truly “alone,” invoking auxiliary roles for minerals,
Reza Hashemi
  +5 more sources

Validating the Matter World Hypothesis: Experimental Evidence for the Inevitable Coexistence and Selection of RNA and DNA Under Prebiotic Conditions

The Matter World Hypothesis posits that prebiotic evolution is governed by physical and chemical constraints, leading to the inevitable coexistence of RNA and DNA prior to biological selection. While theoretically articulated, this hypothesis is strongly supported by experimental synthesis and degradation studies that demonstrate the simultaneous ...
Reza Hashemi
  +5 more sources

Stochastic Simulation of DNA Selection over RNA in Hydrothermal Environments and the Matter World Co-Evolution Hypothesis (Estimated Computational Simulation – Theoretical Framework)

Understanding the emergence and selection of nucleic acids under prebiotic conditions is central to origins-of-life research. We developed a stochastic simulation framework to test whether DNA can outcompete RNA under moderate hydrothermal conditions due to differential stability and polymerization.
Reza Hashemi
  +5 more sources

Casting Doubt on the RNA World Hypothesis♦ [PDF]

Journal of Biological Chemistry, 2013

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Reaching Back to Jump Forward: Recent Efforts towards a Systems‐Level Hypothesis for an Early RNA World

ChemBioChem, 2015
In the spring of the world: Reductive homologation of cyanidic precursors creates the carbon scaffold for multiple classes of biologically relevant compounds. This chemistry underpins a scenario for the formation of a protometabolism on the way to an RNA world.
Greg Springsteen
openalex   +4 more sources

The RNA World Hypothesis: A Critical Reassessment of Prebiotic Plausibility.

Truman, Royal
  +4 more sources