Results 21 to 30 of about 298 (200)
Applications of phage-derived RNA-based technologies in synthetic biology
Synthetic and Systems Biotechnology, 2020 As the most abundant biological entities with incredible diversity, bacteriophages (also known as phages) have been recognized as an important source of molecular machines for the development of genetic-engineering tools.
Wenhui Zhang, Qiong Wu
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Primordial soup or vinaigrette: did the RNA world evolve at acidic pH?
Biology Direct, 2012 Background The RNA world concept has wide, though certainly not unanimous, support within the origin-of-life scientific community. One view is that life may have emerged as early as the Hadean Eon 4.3-3.8 billion years ago with an atmosphere of high CO2 ...
Bernhardt Harold S, Tate Warren P
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The RNA World: 4,000,000,050 years old
Life, 2015 The RNA World is now some four billion years behind us, but only recently turned 50 as a human hypothesis. [...]
Niles Lehman
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An alternative to the RNA World Hypothesis
Trends in Evolutionary Biology, 2011 The RNA world hypothesis for the origin of life is widely accepted in spite of the complexity of RNA synthesis. An alternative hypothesis is advanced for the origin and evolution of protein and nucleic acid synthesis. At an early stage synthesis of poly-( b -malic acid), the initial evolutionary predecessor of nucleic acids, and polypeptides was ...
openaire +2 more sources
Frontiers in Molecular Neuroscience, 2018 The past decade has witnessed exciting breakthroughs that have contributed to the richness and complexity of a burgeoning modern RNA world, and one particular breakthrough—the competing endogenous RNA (ceRNA) hypothesis—has been described as the “Rosetta
Yifei Cai, Jun Wan, Jun Wan
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Comparative analysis of RNA families reveals distinct repertoires for each domain of life.
PLoS Computational Biology, 2012 The RNA world hypothesis, that RNA genomes and catalysts preceded DNA genomes and genetically-encoded protein catalysts, has been central to models for the early evolution of life on Earth.
Marc P Hoeppner +2 more
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FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
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Nonenzymatic RNA-templated Synthesis of N3′→P5′ Phosphoramidate DNA
Bio-Protocol, 2020 The RNA world hypothesis describes a scenario where early life forms relied on RNA to govern both inheritance and catalyze useful chemical reactions.
Derek O'Flaherty +2 more
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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
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