Results 41 to 50 of about 370,027 (271)

Nonenzymatic RNA-templated Synthesis of N3′→P5′ Phosphoramidate DNA

Bio-Protocol, 2020
The RNA world hypothesis describes a scenario where early life forms relied on RNA to govern both inheritance and catalyze useful chemical reactions.
Derek O'Flaherty, Lijun Zhou, Jack Szostak   +2 more
doaj   +1 more source

Origin of Life

, 2012
The evolution of life has been a big enigma despite rapid advancements in the fields of biochemistry, astrobiology, and astrophysics in recent years.
A. Gibbons, Ashwini Kumar Lal, C. Bohler, C. Chyba, C. Huber, C.E. Manning, C.J. Salter, D. Penny, D. Warmflash, D.S. Heckman, D.S. Mckay, E.G. Roussel, F. Hoyle, F. Hoyle, F. Hoyle, G.F. Joyce, H.C. Arp, H.C. Urey, J. Li, J. Maddox, J. Postgate, J.B.S. Haldane, J.K. Fredrickson, J.V. Narlikar, J.W. Schopf, K. Kvenvolden, L.-H. Lin, L.E. Orgel, L.J. Richardson, M.T. Mondigan, N.C. Wickramsinghe, P. David, P. Ehrenfreund, P. Senapathy, R. Shapiro, R.D. Lorenz, S Arrhenius, S.J. Mojzsis, S.L. Miller, S.L. Miller, Stofan, T. Brock, T.D. Brack, W. Gilbert, W. Martin, Y.-J. Kuan, Y.-J. Ma   +46 more
core   +1 more source

In vitro Evolution and Engineering for Improved Ribozyme Polymerase Production [PDF]

, 2011
According to the "RNA World Hypothesis" the first self replicating molecule formed from the prebiotic chemicals is the ribozyme. A model compartmentalized self replicating system for ribozyme polymerases is designed and used to improve activity,
Ayaz Ali Khan, Israr Khan, Muhammad Waheed Akktar   +2 more
core   +1 more source

A creature with a hundred waggly tails: intrinsically disordered proteins in the ribosome [PDF]

, 2013
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Dunker, A. Keith, Kurgan, Lukasz, Mizianty, Marcin J., Oldfield, Christopher J., Peng, Zhenling, Uversky, Vladmir N., Xue, Bin   +6 more
core   +2 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

RNA origin of life [PDF]

, 2010
RNA molekula sadrži genetičku informaciju i ima katalitičku ulogu, te je stoga možemo smatrati pramolekulom života. Njena uloga je vrlo bitna i u danas u biologiji.
Bratovič, Majda
core   +2 more sources

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

RNA Catalysis, Thermodynamics and the Origin of Life

Life, 2014
The RNA World Hypothesis posits that the first self-replicating molecules were RNAs. RNA self-replicases are, in general, assumed to have employed nucleotide 5ʹ-polyphosphates (or their analogues) as substrates for RNA polymerization.
William G. Scott, Abraham Szöke, Josh Blaustein, Sara M. O'Rourke, Michael P. Robertson   +4 more
doaj   +1 more source

The scenario on the origin of translation in the RNA world: in principle of replication parsimony

Biology Direct, 2010
Background It is now believed that in the origin of life, proteins should have been "invented" in an RNA world. However, due to the complexity of a possible RNA-based proto-translation system, this evolving process seems quite complicated and the ...
Ma Wentao
doaj   +1 more source