Results 81 to 90 of about 370,027 (271)
On the origin of DNA genomes: evolution of the division of labor between template and catalyst in model replicator systems. [PDF]
PLoS Computational Biology, 2011 The division of labor between template and catalyst is a fundamental property of all living systems: DNA stores genetic information whereas proteins function as catalysts. The RNA world hypothesis, however, posits that, at the earlier stages of evolution,
Nobuto Takeuchi +2 more
doaj +1 more source
Genetics of common polygenic ischaemic stroke: current understanding and future challenges. [PDF]
, 2011 Stroke is the third commonest cause of death and the major cause of adult neurological disability worldwide. While much is known about conventional risk factors such as hypertension, diabetes and incidence of smoking, these environmental factors only ...
Bevan, S, Markus, HS
core +3 more sources
At the very beginning of life on Earth: the thiol-rich peptide (TRP) world hypothesis.
International Journal of Developmental Biology, 2017 Life developed on Earth probably about 3.8 billion years ago, on a planet that was already largely covered by oceans and where the atmosphere was very humid.
Y. Vallée +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
The evolution and functional repertoire of translation proteins following the origin of life
Biology Direct, 2010 Background The RNA world hypothesis posits that the earliest genetic system consisted of informational RNA molecules that directed the synthesis of modestly functional RNA molecules.
Samudrala Ram +2 more
doaj +1 more source
A mathematical approach for secondary structure analysis can provide an eyehole to the RNA world
bioRxiv, 2016 The RNA pseudoknot is a conserved secondary structure encountered in a number of ribozymes, which assume a central role in the RNA world hypothesis. However, RNA folding algorithms could not predict pseudoknots until recently.
Nikolaos Konstantinides
semanticscholar +1 more source
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source
Mini-ribozymes and freezing environment: a new scenario for the early RNA world
, 2005 International audienceThe RNA World hypothesis states that the present-day life, which is based on DNA genomes and protein enzymes, was preceded by a simpler life form based primarily on RNA.
Vlassov, A. V.
core +1 more source
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source