RNAi efficiency, systemic properties, and novel delivery methods for pest insect control : what we know so far [PDF]
Frontiers in Physiology, 2016 In recent years, the research on the potential of using RNA interference (RNAi) to suppress crop pests has made an outstanding growth. However, given the variability of RNAi efficiency that is observed in many insects, the development of novel approaches
Christiaens, Olivier +3 more
core +3 more sources
Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate [PDF]
EMBO Journal, 2001 Sayda M. Elbashir
openalex +2 more sources
Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1.
New England Journal of Medicine, 2021 BACKGROUND Primary hyperoxaluria type 1 (PH1) is a rare genetic disease caused by hepatic overproduction of oxalate that leads to kidney stones, nephrocalcinosis, kidney failure, and systemic oxalosis. Lumasiran, an investigational RNA interference (RNAi)
Sander F. Garrelfs +24 more
semanticscholar +1 more source
RNAi-Based Therapeutics and Novel RNA Bioengineering Technologies
Journal of Pharmacology and Experimental Therapeutics, 2022 RNA interference (RNAi) provides researchers with a versatile means to modulate target gene expression. The major forms of RNAi molecules, genome-derived microRNAs (miRNAs) and exogenous small interfering RNAs (siRNAs), converge into RNA-induced ...
G. Traber, A. Yu
semanticscholar +1 more source
Off-target effects of RNAi correlate with the mismatch rate between dsRNA and non-target mRNA
RNA Biology, 2021 RNAi is a potent technique for the knockdown of target genes. However, its potential off-target effects limit the widespread applications in both reverse genetic analysis and genetic manipulation.
Jiasheng Chen +7 more
semanticscholar +1 more source
Insight Into the Prospects for RNAi Therapy of Cancer
Frontiers in Pharmacology, 2021 RNA interference (RNAi), also known as gene silencing, is a biological process that prevents gene expression in certain diseases such as cancer. It can be used to improve the accuracy, efficiency, and stability of treatments, particularly genetic ...
Zhili Tian +7 more
semanticscholar +1 more source
Antiviral RNA Interference against Orsay Virus Is neither Systemic nor Transgenerational in Caenorhabditis elegans. [PDF]
, 2015 UNLABELLED: Antiviral RNA-mediated silencing (RNA interference [RNAi]) acts as a powerful innate immunity defense in plants, invertebrates, and mammals. In Caenorhabditis elegans, RNAi is systemic; i.e., RNAi silencing signals can move between cells and ...
Ashe, Alyson +4 more
core +5 more sources
Modeling recursive RNA interference. [PDF]
, 2008 An important application of the RNA interference (RNAi) pathway is its use as a small RNA-based regulatory system commonly exploited to suppress expression of target genes to test their function in vivo.
A Dillin +52 more
core +5 more sources
A Perspective on RNAi-Based Biopesticides
Frontiers in Plant Science, 2020 Sustainable agriculture relies on practices and technologies that combine effectiveness with a minimal environmental footprint. RNA interference (RNAi), a eukaryotic process in which transcript expression is reduced in a sequence-specific manner, can be ...
Stephen J. Fletcher +3 more
semanticscholar +1 more source
Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis
New England Journal of Medicine, 2018 BACKGROUND Patisiran, an investigational RNA interference therapeutic agent, specifically inhibits hepatic synthesis of transthyretin. METHODS In this phase 3 trial, we randomly assigned patients with hereditary transthyretin amyloidosis with ...
D. Adams +35 more
semanticscholar +1 more source