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Open Life SciencesRafflesiaceae is a family of endangered plants whose members are solely parasitic to the tropical grape vine Tetrastigma (Vitaceae). Currently, the genetics of their crosstalk with the host remains unexplored.
Wicaksono Adhityo +5 more
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RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure [PDF]
, 2013 Selective gene silencing by RNA interference (RNAi) involves double-stranded small interfering RNA (ds siRNA) composed of single-stranded (ss) guide and passenger RNAs.
Ahmed +38 more
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Effects of Nanoparticles on Double-Stranded RNA Stability in Moth Hemolymph [PDF]
, 2018 RNA interference (RNAi) is an immune response in which double-stranded RNA (dsRNA) suppresses a target gene. By designing dsRNA to target genes that are necessary for life, dsRNA can potentially be used as an insecticide.
Cooper, Anastasia +7 more
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Journal of Pure and Applied MicrobiologySugarcane (Saccharum officinarum L.) is a highly valuable agricultural crop, cultivated globally in tropical and subtropical regions, primarily for its sugar content.
J. Jernisha +4 more
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Elucidating the Pathogenic Mechanism of Spinal Muscular Atrophy Through the Investigation of UTS2
Frontiers in Bioscience-LandmarkBackground: Spinal muscular atrophy (SMA) is a severe neuromuscular disorder caused by mutations in the survival motor neuron 1 (SMN1) gene, resulting in progressive motor neuron loss and muscle atrophy.
Xu Zhang, Liqi Yang
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Molecular Therapy, 2008 The convergence of the discovery of RNA interference (RNAi) with the completion of the human genome sequencing program has revolutionized our methods of analyzing gene function in mammalian cells.1,2 The task of studying gene function can be relatively easily accomplished by the use of small interfering RNAs (siRNAs) for targeted inhibition of gene ...
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Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells
Molecular & Cellular Oncology, 2019 A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells.
Shawn T. Beug +2 more
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A novel BR-SMAD is required for larval development in barber’s pole worm Haemonchus contortus
Microbial Cell, 2020 SMAD proteins mediate TGF-β signaling and thereby regulate the metazoan development; however, they are poorly defined in Haemonchus contortus–a common blood-sucking parasitic nematode of small ruminants. Here, we characterized an R-SMAD family protein in
Fangfang Li +4 more
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Insects, 2020 The Colorado potato beetle, Leptinotarsa decemlineata (Say), is a significant agricultural pest that has developed resistance to many insecticides that are used to control it.
Grant Favell +2 more
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A Novel Genetic Screen Identifies Modifiers of Age-Dependent Amyloid β Toxicity in the Drosophila Brain [PDF]
, 2017 The accumulation of amyloid β peptide (Aβ) in the brain of Alzheimer's disease (AD) patients begins many years before clinical onset. Such process has been proposed to be pathogenic through the toxicity of Aβ soluble oligomers leading to synaptic ...
Belfiori Carrasco, Lautaro Francisco +5 more
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