Results 91 to 100 of about 330,568 (380)

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Suppression of WWP1 Gene Via RNAi Induced the Reduction of Proliferation Rate of C2C12 Myoblasts

The Journal of Poultry Science, 2010
The WW domain containing E3 ubiquitin protein ligase 1 (WWP1), which plays an important role in ubiquitin-proteasome pathway to degrade unneeded or damaged proteins, was recently identified as the responsible for chicken muscular dystrophy.
Hirokazu Matsumoto, Michihiro Takahama, Ryohsuke Kajiyama, Shinji Sasazaki, Kenji Oyama, Hideyuki Mannen   +5 more
doaj   +1 more source

The ABCB Multidrug Resistance Proteins Do Not Contribute to Ivermectin Detoxification in the Colorado Potato Beetle, Leptinotarsa decemlineata (Say)

Insects, 2020
The Colorado potato beetle, Leptinotarsa decemlineata (Say), is a significant agricultural pest that has developed resistance to many insecticides that are used to control it.
Grant Favell, Jeremy N. McNeil, Cam Donly   +2 more
doaj   +1 more source

Small regulatory RNAs: from bench to bedside – a keystone symposia meeting report

RNA Biology, 2023
The Keystone Symposium ‘Small Regulatory RNAs: From Bench to Bedside’ was held in Santa Fe, New Mexico from May 1–4, 2022. The symposium was organized by Frank J. Slack, Jörg Vogel, Ivan Martinez and Karyn Schmidt, and brought together scientists working
Soo Mi Lee, Michael T. Winters, Ivan Martinez, Frank J. Slack   +3 more
doaj   +1 more source

RNAi in Insects: A Revolution in Fundamental Research and Pest Control Applications

Insects, 2020
In this editorial for the Special Issue on ‘RNAi in insect pest control’, three important applications of RNA interference (RNAi) in insects are briefly discussed and linked to the different studies published in this Special Issue.
O. Christiaens, J. Niu, Clauvis Nji Tizi Taning   +2 more
semanticscholar   +1 more source

Chromatin Topology Reconfiguration Orchestrates Thermotolerant Male Fertility via GhAL5 in Cotton

Advanced Science, EarlyView.
This study investigates cotton’s high‐temperature (HT) response using multi‑omics. Dynamic 3D genome changes drive expression bias affecting male fertility. The tolerant line shows controlled chromatin dynamics, while the sensitive line exhibits overactivation.
Yanlong Li, Jing Yang, Weiran Wang, Chunyang Zuo, Liuling Pei, Yizan Ma, Rui Zhang, Yaru Fan, Huanhuan Ma, Yawei Li, Ruizhen Liu, Shuangxia Jin, Longfu Zhu, Jie Kong, Xianlong Zhang, Ling Min   +15 more
wiley   +1 more source

Splice variants of DOMINO control Drosophila circadian behavior and pacemaker neuron maintenance. [PDF]

, 2019
Circadian clocks control daily rhythms in behavior and physiology. In Drosophila, the small ventral lateral neurons (sLNvs) expressing PIGMENT DISPERSING FACTOR (PDF) are the master pacemaker neurons generating locomotor rhythms.
Cai, Yao, Chiu, Joanna C, Lam, Vu H, Liu, Zhenxing, Mcintire, Pearson, Niu, Ye, Tabuloc, Christine A, Xue, Yongbo, Zhang, Yong   +8 more
core   +1 more source

A GLUTAMATE CYSTEINE LIGASE Gene StGSH1 Regulated by StERF10 Enhanced Glutathione Accumulation and Adaptation to Low Phosphorus Stress in Potato

Advanced Science, EarlyView.
The StERF10‐StGSH1 module coordinates glutathione (GSH) biosynthesis under low‐phosphorus stress. The low‐phosphate‐induced AP2/ERF transcription factor StERF10 directly activates the transcription of StGSH1 and enhances GSH accumulation. Consequently, GSH scavenges reactive oxygen species and provides sulfur for sulfolipid synthesis, facilitating the ...
Xiaocheng Tian, Mingjun Li, Xiaojia Huang, Markus Wirtz, Xiaohui Zheng, Shilong Fan, Jiang Tian, Shaoqun Liu, Zhonghua Liu, Hongbo Zhao   +9 more
wiley   +1 more source

Hairpin in a haystack: In silico identification and characterization of plant-conserved microRNA in Rafflesiaceae

Open Life Sciences
Rafflesiaceae is a family of endangered plants whose members are solely parasitic to the tropical grape vine Tetrastigma (Vitaceae). Currently, the genetics of their crosstalk with the host remains unexplored.
Wicaksono Adhityo, Meitha Karlia, Wan Kiew-Lian, Mat Isa Mohd Noor, Parikesit Arli Aditya, Molina Jeanmaire   +5 more
doaj   +1 more source

PhSLB1 Regulates Branch Development in Petunia

Journal of the American Society for Horticultural Science
F-box proteins play crucial roles in various developmental stages in plants, such as shoot branching. As an important ornamental and model plant, the branch development of petunia has always been a hot research topic. In our study, the homologous gene of
Jichu Deng, Xinyi Deng, Mengyu Zhang, Ziyan Tang, Lili Dong   +4 more
doaj   +1 more source