Results 91 to 100 of about 323,847 (388)

RNAi Degrades the SARS-CoV-2 Spike Protein RNA for Developing Drugs to Treat COVID-19

Nano Biomedicine and Engineering, 2022
COVID-19 is caused by severe acute respiratory SARS-CoV-2. Regardless of the availability of treatment strategies for COVID-19, effective therapy will remain essential.
Weiwei Zhang, Linjia Huang, Jumei Huang, Xin Jiang, Xiaohong Ren, Xiaojie Shi, Ling Ye, Shuhui Bian, Jianhe Sun, Yufeng Gao, Zehua Hu, Lintin Guo, Suyan Chen, Jiahao Xu, Jie Wu, Jiwen Zhang, Daxiang Cui, Fangping Dai   +17 more
doaj   +1 more source

Suppression of Argonaute 2 Transcript Levels in Du182A Cells [PDF]

, 2018
RNA interference (RNAi) uses double-stranded RNA (dsRNA) molecules to degrade and suppress the transcript level of a complementary mRNA target1.
Featherston, Kyah, Schneck, Karen, Silver, Kristopher   +2 more
core  

NTRC Plays a Crucial Role in Starch Metabolism, Redox Balance, and Tomato Fruit Growth [PDF]

, 2019
NADPH-thioredoxin reductase C (NTRC) forms a separate thiol-reduction cascade in plastids, combining both NADPHthioredoxin reductase and thioredoxin activities on a single polypeptide.
Cejudo Fernández, Francisco Javier, Ehrlich, Matthias, Fernie, Alisdair R., Geigenbergera, Peter, Hou, Liang-Yu, Krahnert, Ina, Lehmann, Martin, Obata, Toshihiro, Thormählen, Ina   +8 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Suppression of WWP1 Gene Via RNAi Induced the Reduction of Proliferation Rate of C2C12 Myoblasts

The Journal of Poultry Science, 2010
The WW domain containing E3 ubiquitin protein ligase 1 (WWP1), which plays an important role in ubiquitin-proteasome pathway to degrade unneeded or damaged proteins, was recently identified as the responsible for chicken muscular dystrophy.
Hirokazu Matsumoto, Michihiro Takahama, Ryohsuke Kajiyama, Shinji Sasazaki, Kenji Oyama, Hideyuki Mannen   +5 more
doaj   +1 more source

Whats, hows and whys of programmed DNA elimination in Tetrahymena [PDF]

Open Biology, 2017
Programmed genome rearrangements in ciliates provide fascinating examples of flexible epigenetic genome regulations and important insights into the interaction between transposable elements (TEs) and host genomes.
Tomoko Noto, Kazufumi Mochizuki
doaj   +1 more source

RNAi in Budding Yeast [PDF]

Science, 2009
Yeast Joins RNAi Club RNA interference (RNAi) silences gene expression via small interfering (si) RNAs that bind to target sequences. RNAi has been found in almost all eukaryotes examined, with the notable exception of the budding yeast, Saccharomyces cerevisiae , one of the most prominent organisms used ...
Drinnenberg, Ines A., Weinberg, David E., Xie, Kathleen Dongqin, Mower, Jeffrey P., Wolfe, Kenneth H., Bartel, David, Fink, Gerald R   +6 more
openaire   +4 more sources

Management of Pest Insects and Plant Diseases by Non-Transformative RNAi

Frontiers in Plant Science, 2019
Since the discovery of RNA interference (RNAi), scientists have made significant progress towards the development of this unique technology for crop protection.
Deise Cagliari, N. Dias, D. M. Galdeano, Ericmar Ávila dos Santos, G. Smagghe, M. Zotti   +5 more
semanticscholar   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

The Trypanosoma brucei AIR9-like protein is cytoskeleton-associated and is required for nucleus positioning and accurate cleavage furrow placement [PDF]

, 2012
AIR9 is a cytoskeleton-associated protein in Arabidopsis thaliana with roles in cytokinesis and cross wall maturation, and reported homologues in land plants and excavate protists, including trypanosomatids.
Almeida Costa, Cristina, Gibson, Wendy, Hammarton, Tansy, May, Sophie, Peacock, Lori, Robinson, Derrick, Robinson, Derrick R, Tetley, Laurence   +7 more
core   +2 more sources