Results 101 to 110 of about 195,676 (344)
Nano-based delivery of RNAi in cancer therapy
Molecular Cancer, 2017 RNA interference (RNAi), a newly developed method in which RNA molecules inhibit gene expression, has recently received considerable research attention. In the development of RNAi-based therapies, nanoparticles, which have distinctive size effects along ...
Y. Xin +5 more
semanticscholar +1 more source
RNAi as a bioinformatics consumer [PDF]
Briefings in Bioinformatics, 2005 RNAi has shown great potential for use as a tool for biological discovery, analysis and therapeutics. The involvement of the RNAi pathway in post-transcription silencing, transcriptional silencing and epigenetic silencing as well as its use as a tool for forward genetics and therapeutics throws up several bioinformatics challenges.
openaire +2 more sources
Advanced Science, EarlyView.Abnormal mechanical stretch induced by mechanical ventilation (MV) disrupts endothelial junctions via the NOX2/ROS/CaMKII/ERK1/2 axis both in human aortic endothelial cells (HAECs) in vitro and in ventilator‐induced lung injury (VILI) in mice. Quercetin, an antioxidant predicted to bind to NOX2, can effectively prevent mechanical stretch‐induced ...
Tao Jiang +8 more
wiley +1 more source
A nuclease specific to lepidopteran insects suppresses RNAi
Journal of Biological Chemistry, 2018 More than 70% of all agricultural pests are insects in the order Lepidoptera, which, unlike other related insect orders, are not very sensitive to RNAi, limiting genetic studies of this insect group.
Ruobing Guan +6 more
semanticscholar +1 more source
RNAi and retroviruses: are they in RISC?
BioMolecular Concepts, 2013 AbstractRNA interference (RNAi) is a potent cellular system against viruses in various organisms. Although common traits are observed in plants, insects, and nematodes, the situation observed in mammals appears more complex. In mammalian somatic cells, RNAi is implicated in endonucleolytic cleavage mediated by artificially delivered small interfering ...
Charles-Henri Lecellier +3 more
openaire +4 more sources
Advanced Science, EarlyView.KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma +9 more
wiley +1 more source
Insects, 2019 Clip domain serine proteases play vital roles in various innate immune functions and in embryonic development. Nilaparvata lugens proclotting enzymes (NlPCEs) belong to this protease family.
Jia-min Wu +5 more
doaj +1 more source
RNA Interference (RNAi)-Based Therapeutics: Delivering on the Promise?
Annual Review of Pharmacology and Toxicology, 2016 A resurgence in clinical trials using RNA interference (RNAi) occurred in 2012. Although there were initial difficulties in achieving efficacious results with RNAi without toxic side effects, advances in delivery and improved chemistry made this ...
Maggie L. Bobbin, J. Rossi
semanticscholar +1 more source
Advanced Science, EarlyView.Dysregulated RNA splicing is an underappreciated molecular feature of cancer. By integrating murine and cellular models with patient specimens of lung adenocarcinoma, this study demonstrates that RAC1B, rather than RAC1A isoform, promotes tumorigenesis and presents a potent therapeutic target for lung cancer. Mechanistically, RAC1B preferentially binds
Yueren Yan +19 more
wiley +1 more source
Limitations in harnessing oral RNA interference as an antiviral strategy in Aedes aegypti
iScienceSummary: Mosquitoes, particularly Aedes aegypti, are critical vectors for globally significant pathogenic viruses. This study examines the limitations of oral RNA interference (RNAi) as a strategy to disrupt viral transmission by Ae. aegypti.
Ottavia Romoli +4 more
doaj