Results 101 to 110 of about 323,847 (388)

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

A Bayesian measurement error model for two-channel cell-based RNAi data with replicates

, 2012
RNA interference (RNAi) is an endogenous cellular process in which small double-stranded RNAs lead to the destruction of mRNAs with complementary nucleoside sequence. With the production of RNAi libraries, large-scale RNAi screening in human cells can be
Chang, I-Shou, Chen, Chih-Yu, Chen, Chung-Hsing, Hsiung, Chao A., Huang, Jing-Ying, Jeng, King-Song, Su, Wen-Chi, Tsai, Fang-Yu, Wang, Wen-Chang   +8 more
core   +1 more source

Complementary transcriptomic, lipidomic, and targeted functional genetic analyses in cultured Drosophila cells highlight the role of glycerophospholipid metabolism in Flock House virus RNA replication [PDF]

, 2010
Background Cellular membranes are crucial host components utilized by positive-strand RNA viruses for replication of their genomes. Published studies have suggested that the synthesis and distribution of membrane lipids are particularly important for the
Castorena, Kathryn M, Miller, David J., Stapleford, Kenneth Arthur   +2 more
core   +4 more sources

Development of RNAi in Insects and RNAi-Based Pest Control [PDF]

, 2011
In agricultural systems, insect pests can cause crop damage mainly through loss in yield or quality resulting in a loss in profits for farmers. Worldwide pests cost billions of dollars due to damage and use of pesticides. Chemical pesticides are still the major approach for controlling insect pests, but they are associated with significant hazards to ...
Chunhui Liu, Minsheng You, Guang Yang, Yiying Zhao, Liette Vasseur   +4 more
openaire   +3 more sources

Reconfigurable Nucleic Acid Nanoparticles with Therapeutic RNAi Responses to Intracellular Disease Markers

Advanced Functional Materials, EarlyView.
Many known diseases arise from dysregulated gene expression, and differentially expressed genes can serve as biomarkers to distinguish diseased cells from healthy tissues. In this study, reconfigurable nucleic acid nanoparticles (recNANPs) are introduced that can detect overexpressed cancer biomarkers and subsequently release RNAi inducers to silence ...
Yelixza I. Avila, Anh Ha, Morgan R. Chandler, Nathalia Leal Santos, Taejin Kim, Hannah S. Newton, Marina A. Dobrovolskaia, Kirill A. Afonin   +7 more
wiley   +1 more source

In silico analyses of miRNAs that Target Odorant Binding and Chemosensory Proteins in Bemisia tabaci

Turkish Journal of Agriculture: Food Science and Technology
The whitefly, Bemisia tabaci, damages various crops by releasing honeydew and spreading. Although farmers and pest control experts primarily rely on insecticides to manage whiteflies, the notable issue is their tendency to develop resistance to major ...
Mehtap Bal, Sevgi Maraklı
doaj   +1 more source

Sense- and antisense-mediated resistance against Sri Lankan cassava mosaic virus (SLCMV) in Nicotiana benthamiana

Biologia Plantarum, 2019
Sri Lankan cassava mosaic virus (SLCMV) is the principal causal agent of cassava mosaic disease in the Indian subcontinent. To gain resistance against the virus, the coat protein (CP) gene, namely the AV1 of SLCMV-Adivaram isolate, was cloned in either ...
A. GOGOI, A. KALDIS, I. DASGUPTA, B.K. BORAH, A. VOLOUDAKIS   +4 more
doaj   +1 more source

NEW Fangled Tactics Towards Cotton Leaf Curl Virus Disease A Review

Journal of Natural Fibers, 2023
CLCuVD is the most ravaging biotic stress to cotton crop and is responsible for the withdrawal of various varieties in cotton cultivation across the globe. CLCuV significantly degrades the quality and productivity of cotton.
Muhammad Atiq, Muhammad Zeeshan Talib, Nasir Ahmed Rajput, Shahbaz Talib Sahi, Muhammad Aslam Khan, Muhammad Usman, Abdul Jabar, Muhammad Jalal Arif, Muhammad Dildar Gogi, Muhammad Ahsan Khan, Azeem Akram   +10 more
doaj   +1 more source

Sphingosine Phosphate Lyase Expression Is Essential for Normal Development in Caenorhabditis elegans [PDF]

, 2003
Sphingolipids are ubiquitous membrane constituents whose metabolites function as signaling molecules in eukaryotic cells. Sphingosine 1-phosphate, a key sphingolipid second messenger, regulates proliferation, motility, invasiveness, and programmed cell ...
Fyrst, Henrik, Heinecke, Karie, Mendel, Jane, Saba, Julie D.   +3 more
core   +1 more source

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

Advanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki, Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori   +20 more
wiley   +1 more source