Results 11 to 20 of about 195,676 (344)
Genome Biology, 2001 Abstract A method for double-stranded RNA interference of gene expression in mammalian cells.
Edupalli Subbaiah Venkata
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Genome Biology, 2002 Long hairpin-forming double-stranded RNAs provoke specific suppression of gene expression in murine embryonic cells that is strongly suggestive of conventional RNA ...
Chris Berrie
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Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate [PDF]
EMBO Journal, 2001 Sayda M. Elbashir
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Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1.
New England Journal of Medicine, 2021 BACKGROUND Primary hyperoxaluria type 1 (PH1) is a rare genetic disease caused by hepatic overproduction of oxalate that leads to kidney stones, nephrocalcinosis, kidney failure, and systemic oxalosis. Lumasiran, an investigational RNA interference (RNAi)
Sander F. Garrelfs +24 more
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RNAi-Based Therapeutics and Novel RNA Bioengineering Technologies
Journal of Pharmacology and Experimental Therapeutics, 2022 RNA interference (RNAi) provides researchers with a versatile means to modulate target gene expression. The major forms of RNAi molecules, genome-derived microRNAs (miRNAs) and exogenous small interfering RNAs (siRNAs), converge into RNA-induced ...
G. Traber, A. Yu
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Insight Into the Prospects for RNAi Therapy of Cancer
Frontiers in Pharmacology, 2021 RNA interference (RNAi), also known as gene silencing, is a biological process that prevents gene expression in certain diseases such as cancer. It can be used to improve the accuracy, efficiency, and stability of treatments, particularly genetic ...
Zhili Tian +7 more
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Bacterial Delivery of RNAi Effectors: Transkingdom RNAi [PDF]
Journal of Visualized Experiments, 2010 RNA interference (RNAi) represents a high effective mechanism for specific inhibition of mRNA expression. Besides its potential as a powerful laboratory tool, the RNAi pathway appears to be promising for therapeutic utilization. For development of RNA interference (RNAi)-based therapies, delivery of RNAi-mediating agents to target cells is one of the ...
Hermann Lage, Andrea Krühn
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Off-target effects of RNAi correlate with the mismatch rate between dsRNA and non-target mRNA
RNA Biology, 2021 RNAi is a potent technique for the knockdown of target genes. However, its potential off-target effects limit the widespread applications in both reverse genetic analysis and genetic manipulation.
Jiasheng Chen +7 more
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Developmental Cell, 2011 Small non-coding RNAs, through association with Argonaute protein family members, have a variety of functions during the development of an organism. Although there is increased mechanistic understanding of the RNA interference (RNAi) pathways surrounding these small RNAs, how their effects are modulated by subcellular compartmentalization and cross ...
René F. Ketting, René F. Ketting
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Asian Citrus Psyllid RNAi Pathway – RNAi evidence [PDF]
Scientific Reports, 2016 AbstractDiaphorina citri, known as the Asian citrus psyllid, is an important pest of citrus because it transmits a phloem-limited bacteria strongly implicated in huanglongbing (citrus greening disease). Emerging biotechnologies, such as RNA interference, could provide a new sustainable and environmentally friendly strategy for the management of this ...
Taning, Nji Tizi Clauvis +4 more
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