Inhibition of cd46 receptor by rnai enhances cell resistance to bvdv infection [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2020 This study aimed to investigate the inhibition effect of CD46 on the replication of bovine viral diarrhea viruses (BVDV). BVDV causes bovine viral diarrheal mucosal disease, and prevention of BVDV infection is very important for livestock production ...
Ruirui HU +7 more
doaj +1 more source
Off-target effects of RNAi correlate with the mismatch rate between dsRNA and non-target mRNA
RNA Biology, 2021 RNAi is a potent technique for the knockdown of target genes. However, its potential off-target effects limit the widespread applications in both reverse genetic analysis and genetic manipulation.
Jiasheng Chen +7 more
semanticscholar +1 more source
Insight Into the Prospects for RNAi Therapy of Cancer
Frontiers in Pharmacology, 2021 RNA interference (RNAi), also known as gene silencing, is a biological process that prevents gene expression in certain diseases such as cancer. It can be used to improve the accuracy, efficiency, and stability of treatments, particularly genetic ...
Zhili Tian +7 more
semanticscholar +1 more source
Mapping the Salt Stress-Induced Changes in the Root miRNome in Pokkali Rice
Biomolecules, 2020 A plant’s response to stress conditions is governed by intricately coordinated gene expression. The microRNAs (miRs) have emerged as relatively new players in the genetic network, regulating gene expression at the transcriptional and post ...
Kavita Goswami +4 more
doaj +1 more source
Antiviral RNA Interference against Orsay Virus Is neither Systemic nor Transgenerational in Caenorhabditis elegans. [PDF]
, 2015 UNLABELLED: Antiviral RNA-mediated silencing (RNA interference [RNAi]) acts as a powerful innate immunity defense in plants, invertebrates, and mammals. In Caenorhabditis elegans, RNAi is systemic; i.e., RNAi silencing signals can move between cells and ...
Ashe, Alyson +4 more
core +5 more sources
Next-generation 9216-microwell cell arrays for high-content screening microscopy
BioTechniques, 2009 Reverse transfection on cell arrays is a high-throughput method for the parallel transfection of mammalian cells for use in high-content screening light microscopy.
Jürgen Reymann +5 more
doaj +1 more source
Identification and functional analysis of a testis‑biased gene encoding serine/arginine‑rich protein in silkworm, Bombyx mori [PDF]
Archives of Biological Sciences, 2019 Spermatogenesis is a fundamental process in sexual reproduction. In this study, we cloned a 716-bp cDNA of a testis-biased gene in Bombyx mori, named as BmRS-TS, which encodes a polypeptide of 164 amino acids, containing 26.7% arginine and serine ...
Zhang Li-Ying, Li Juan, Zha Xing-Fu
doaj +1 more source
Modeling recursive RNA interference. [PDF]
, 2008 An important application of the RNA interference (RNAi) pathway is its use as a small RNA-based regulatory system commonly exploited to suppress expression of target genes to test their function in vivo.
A Dillin +52 more
core +5 more sources
Postembryonic RNAi in Heterorhabditis bacteriophora: a nematode insect parasite and host for insect pathogenic symbionts [PDF]
, 2007 Background: Heterorhabditis bacteriophora is applied throughout the world for the biological control of insects and is an animal model to study interspecies interactions, e.g. mutualism, parasitism and vector-borne disease. H. bacteriophora nematodes are
Ciche, Todd A., Sternberg, Paul W.
core +4 more sources
Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis
New England Journal of Medicine, 2018 BACKGROUND Patisiran, an investigational RNA interference therapeutic agent, specifically inhibits hepatic synthesis of transthyretin. METHODS In this phase 3 trial, we randomly assigned patients with hereditary transthyretin amyloidosis with ...
D. Adams +35 more
semanticscholar +1 more source