Results 191 to 200 of about 195,676 (344)

Nuclear destabilisation – a possible genesis of cancer?

Biological Reviews, EarlyView.
ABSTRACT This review examines the increasingly prominent role of mechanics within cancer formation and progression. The extremely varied and contradictory genetic landscape of cancer is in stark contrast to the seemingly universal mechanical characteristics of cancer cells and their tumour microenvironment, and mechanics may be a principal unifying ...
Daniel D. Scott, Francesco Bettariga, Marco Ventin, Chris Bishop, Britta Stordal   +4 more
wiley   +1 more source

LIN-39 is a neuron-specific developmental determinant of longevity in Caenorhabditis elegans with reduced insulin signaling. [PDF]

Nat Commun
Kavšek A, Salignon J, Millan-Ariño L, Marcinkowski P, Sen I, Riedel CG.   +5 more
europepmc   +1 more source

Dauricine Overcomes Osimertinib Resistance in Lung Cancer by Inducing Ferroptosis via Stabilizing SAT1

Cancer Science, EarlyView.
Our study explores the potential of dauricine, a bioactive compound from Menispermum dauricum, to overcome osimertinib resistance in lung cancer. We demonstrate that dauricine, when combined with osimertinib, induces ferroptosis in resistant lung cancer cells by stabilizing SAT1, a key enzyme in oxidative stress regulation.
Biying Men, Zhijie Chen, Haotian Ge, Zhuoying Yang, Liang Yun, Jianjun Jiang, Meijuan Dian, Yujing He, Zehao Zhou, Ruihao Zhang, Tianbao Yan, Zichao Li, Yingxin Zhang, Yongjie He, Junming He, Xuguang Rao, Shuan Rao   +16 more
wiley   +1 more source

A Highly Durable RNAi Therapeutic Inhibitor of PCSK9

New England Journal of Medicine, 2017
K. Fitzgerald, S. White, A. Borodovsky, B. Bettencourt, A. Strahs, Valerie A. Clausen, P. Wijngaard, J. Horton, J. Taubel, Ashley Brooks, Chamikara Fernando, R. Kauffman, D. Kallend, A. Vaishnaw, A. Simon   +14 more
semanticscholar   +2 more sources

Functional analysis of <i>StWRKY75</i> gene in response to heat stress in potato (<i>Solanum tuberosum</i> L.). [PDF]

Front Plant Sci
Zhu X, Duan X, Majeed Y, Luo J, Guan N, Zheng H, Zou H, Jin H, Chen Z, Zhang Y.   +9 more
europepmc   +1 more source

A chemical‐regulated inducible RNAi system in plants [PDF]

, 2003
Hui‐Shan Guo, Ji‐Feng Fei, Qi Xie, Nam‐Hai Chua   +3 more
openalex   +1 more source

Epigenetically‐Upregulated CD98 Shed Light on the Precancerous Diagnosis and Prognosis Prediction of Esophageal Cancer

Cancer Science, EarlyView.
This study confirmed that hypomethylation‐induced upregulation of CD98 promoted ESCC cell proliferation by regulating the cell cycle and was correlated with poorer overall survival of ESCC patients. Combined panels of immunohistochemistry (CD98 and P53) are recommended for accurate diagnosis of esophageal precancerous lesions.
Xue Zhang, Mengfei Sun, Na Li, Jie Yu, Wenjie Wang, Ju Yang, Hongyan Wu, Linyue Zhao, Huakun Zhang, Lan Yang, Feng Li, Qi Sun, Yunzhao Chen, Xiaobin Cui   +13 more
wiley   +1 more source

Engineering saline-alkali-tolerant apple rootstock by knocking down MdGH3 genes in M9-T337. [PDF]

Stress Biol
Zhi F, Fan T, Li J, Zhang S, Qian Q, Khalil A, Niu C, Wang K, Ma F, Li X, Guan Q.   +10 more
europepmc   +1 more source

Molecular Correlates of Genes Exhibiting RNAi Phenotypes in Caenorhabditis elegans [PDF]

, 2003
Asher D. Cutter
openalex   +1 more source

Infantile Cerebellar‐Retinal Degeneration Associated With Novel ACO2 Variants: Clinical Features and Insights From a Drosophila Model

Clinical Genetics, EarlyView.
Our Translational Loop integrates patient genetic data with Drosophila models to study disease mechanisms. We identified ACO2 variants in a patient linked to ICRD and show that our animal model mirrors key aspects of the disease. These insights help pinpoint therapeutic targets, advancing research toward treatments for rare genetic disorders.
Edgar Buhl, Suchika Garg, Marie Monaghan, Amy Preston, Marcus Likeman, Julianne Dare, Julie Evans, Lucie S. Taylor, Ian Berry, Kathryn Urankar, Paul G. D. Spry, Cathy Williams, Robert W. Taylor, Charlotte L. Alston, James J. L. Hodge, Anirban Majumdar   +15 more
wiley   +1 more source