Results 201 to 210 of about 323,847 (388)

The Role of Diaphanous in Ring Canal Development in Drosophila melanogaster [PDF]

, 2016
Infertility is a widespread condition that does not always have a known cause, and for which we often do not have a cure. One potential cause of infertility is defects in gametogenesis, or the formation of sperm and egg.
Kindred, Alexandra M.
core   +1 more source

Just add water: A simple floral bud injection method for stable Agrobacterium‐mediated transformation in two ecotypes of Mimulus guttatus

Applications in Plant Sciences, EarlyView.
Abstract Premise Stable transformation is the biggest barrier to studying gene function in plants. In most species, transformation requires tissue culture and regeneration methods that may be arduous and cause undesirable genetic changes. Floral dip methods bypass these challenges by directly transforming ovules of developing flowers, but these methods
Lauren E. Stanley, David B. Lowry
wiley   +1 more source

The dsRNA Binding Protein RDE-4 Interacts with RDE-1, DCR-1, and a DExH-Box Helicase to Direct RNAi in C. elegans [PDF]

, 2002
Hiroaki Tabara, Erbay Yigit, Haruhiko Siomi, Craig C. Mello   +3 more
openalex   +1 more source

RNAi Double-Stranded RNA Directs the ATP-Dependent Cleavage of mRNA at 21 to 23 Nucleotide Intervals

Cell, 2000
P. Zamore, T. Tuschl, P. Sharp, D. Bartel   +3 more
semanticscholar   +1 more source

Alu Overexpression Leads to an Increased Double‐stranded RNA Signature in Dermatomyositis

Arthritis &Rheumatology, Accepted Article.
Objective Dermatomyositis is an autoimmune condition characterized by a high interferon signature of unknown etiology. Because coding sequences constitute <1.2% of our genomes, there is a need to explore the role of the non‐coding genome in disease pathogenesis.
Rayan Najjar, Andrew Mammen, Tomas Mustelin   +2 more
wiley   +1 more source

Stable suppression of gene expression by RNAi in mammalian cells [PDF]

, 2002
Patrick J. Paddison, Amy A. Caudy, Gregory J. Hannon   +2 more
openalex   +1 more source

Short‐chain acyl post‐translational modifications in cancers: Mechanisms, roles, and therapeutic implications

Cancer Communications, EarlyView.
Abstract Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, and lactyl, at specific protein sites, which alter protein structure, function, stability, and activity ...
Ting Wu, Yingqi Zhao, Xin Zhang, Yuanhe Wang, Qiuchen Chen, Mingrong Zhang, Huan Sheng, Yuying Zhang, Jinyu Guo, Jun Li, Yuxuan Fan, Ziqing Wang, Yalun Li, Haoran Wang, Minjie Wei, Xiaoyun Hu, Huizhe Wu   +16 more
wiley   +1 more source

Glycolysis modulates trypanosome glycoprotein expression as revealed by an RNAi library [PDF]

, 2002
James C. Morris
openalex   +1 more source

Mitochondria‐Targeted Delivery of siRNA by Amphiphilic Nanovectors Self‐Assembled from a Cationic [4]Helicene‐Squalene Ester

ChemBioChem, EarlyView.
A small amphiphilic helicene effectively complexes siRNA, leading to nanoassemblies which transport siRNA to the mitochondria where it silences the protein expression of the mitochondria‐encoded cytochrome c oxidase subunit 1 gene. The active delivery of therapeutic nucleic acids with subcellular precision is an open challenge.
Lamiaa M. A. Ali, Dan–Dan Su, Rebecca Mucci, Kévin Martin, Mihail Barboiu, Jérôme Lacour, Nadir Bettache, Sébastien Ulrich   +7 more
wiley   +1 more source

RNAi-mediated oncogene silencing confers resistance to crown gall tumorigenesis

, 2001
Matthew A. Escobar, Edwin L. Civerolo, Kristin R. Summerfelt, Abhaya M. Dandekar   +3 more
openalex   +1 more source