Bacillus secretes nucleases to degrade dsRNA, thereby reducing host's susceptibility to RNAi. [PDF]
Han X, Li H, Xu S, Miao X, Guan R.
europepmc +1 more source
RNAi-mediated depletion of the 15 KH domain protein, vigilin, induces death of dividing and non-dividing human cells but does not initially inhibit protein synthesis [PDF]
Kathryn M. Goolsby
openalex +1 more source
WNT5a export onto extracellular vesicles studied at single‐molecule and single‐vesicle resolution
WNT signaling, which orchestrates tissue development and homeostasis, is mediated by hydrophobic WNT proteins traveling from secreting to receiving cells on various carriers. Here, fusion constructs of fluorescent proteins with WNT5a were developed and functionally validated.
Antonia Schubert+16 more
wiley +1 more source
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
J. Zuber+19 more
semanticscholar +1 more source
Unraveling the functional dynamics of Caenorhabditis elegans stress‐responsive omega class GST‐44
Omega‐class glutathione S‐transferases (GSTs) are integral to redox regulation and cellular stress responses. This study characterized GST‐44 in Caenorhabditis elegans, revealing its predominant expression in the intestine and excretory H‐cell, with significant upregulation under various stress conditions.
Charlotte Sophia Kaiser+9 more
wiley +1 more source
Key RNA-binding domains in the La protein establish tRNA modification levels in Trypanosoma brucei. [PDF]
Gunaratne L+13 more
europepmc +1 more source
Efficient RNA interference (RNAi) in Mamallian Cells [PDF]
Kumar Somasundaram
openalex +1 more source
Transcription‐coupled repair: tangled up in convoluted repair
In this review, we discuss recent findings derived from diverse genomic, biochemical and structural, imaging, and functional studies (B–E) that culminated in deep mechanistic insight (A) into the vital cellular process of transcription‐coupled nucleotide excision repair (TC‐NER).
Diana A. Llerena Schiffmacher+3 more
wiley +1 more source
An RNAi screen of Rab GTPase genes in Caenorhabditis elegans reveals that morphogenesis has a higher demand than stem cell niche maintenance for rab-1 in the somatic cells of the reproductive system. [PDF]
Singh N, Scott K, Proctor J, Gordon KL.
europepmc +1 more source