Results 61 to 70 of about 179,366 (172)

Distinct Nanohoop Structures and Ratiometric Emissions of Isomeric DPAC‐Based Macrocycles Tuned by Nano‐Twisting of Stiff‐Stilbene Optical‐Switches

Small, EarlyView.
Tunable nano‐twisted structures of novel isomeric macrocycles, which were controlled by cis/trans isomerizations of stiff‐stilbene units under light irradiations, have been exploited to modulate bent and planar configurations of 9,14‐diphenyl‐9,14‐dihydrodibenzo[a,c]phenazine (DPAC) moieties and adjust their ratiometric emissions. External factors, i.e.
Nguyen Thanh Trung, Shao‐Chen Lu, Po‐Jung Tseng, Tu Thi Kim Cuc, Chun‐Wei Huang, Jeng‐Kuei Chang, Said Jalife, Judy I. Wu, Simona Steponkiene, Vitalijus Karabanovas, Tung‐Kung Wu, Hong‐Cheu Lin   +11 more
wiley   +1 more source

Phenotypic Florfenicol Resistance in floR‐Harbouring Flavobacterium psychrophilum Isolates (CC‐ST90): A Case Study From Danish Freshwater Rainbow Trout Aquaculture

Journal of Fish Diseases, EarlyView.
ABSTRACT Monitoring antimicrobial resistance (AMR) in fish pathogens is essential for supporting sustainable aquaculture. In this study, susceptibility testing and genome sequencing were used to characterize the AMR profile of seven Flavobacterium psychrophilum originating from Danish rainbow trout farms (2019–2022).
Valentina L. Donati, Lone Madsen
wiley   +1 more source

Cryo-EM reveals the structural heterogeneity and conformational flexibility of multidrug efflux pumps MdtB and MdtF

mBio
Resistance-nodulation-cell division (RND) efflux pumps are the major cause of multidrug resistance in bacteria, particularly in Gram-negative bacteria. They are complex molecular machines forming tripartite assemblies that actively transport out a wide ...
Surekha Padmanaban, Clayton Fernando Rencilin, Rupam Biswas, Somnath Dutta   +3 more
doaj   +1 more source

Assessing the role of the RND efflux pump in metronidazole resistance of Helicobacter pylori by RT-PCR assay

Journal of Infection in Developing Countries, 2010
Introduction: Metronidazole is a significant antibiotic used for eradication of Helicobactor pylori infections and it is of notice that metronidazole-resistant clinical isolates have been found in high rates worldwide.
Jalil Fallah Mehrabadi, Mehrandokht Sirous, Naser Ebrahimi Daryani, Saeed Eshraghi, Bahram Akbari, Mohammad Hasan Shirazi   +5 more
doaj   +1 more source

Identification of Promoter Region Markers Associated With Altered Expression of Resistance-Nodulation-Division Antibiotic Efflux Pumps in Acinetobacter baumannii

Frontiers in Microbiology, 2022
Genetic alterations leading to the constitutive upregulation of specific efflux pumps contribute to antibacterial resistance in multidrug resistant bacteria.
Mireia López-Siles, Michael J. McConnell, Antonio J. Martín-Galiano   +2 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, Volume 13, Issue 9, Page 1817-1830, September 2026.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

RND family efflux pumps: from antibioresistance to chemotherapy resistance

Swedish Journal of BioScience Research, 2020
Resistance to chemotherapy can be studied comparatively to the study of resistance in microorganisms. For over 40 years, understanding mechanisms that confer MDR has been a major goal of cancer biologists. Most of the studies toward MDR in cancer cells were about ABC transporters.
Méliné Simsir, Isabelle Mus-Veteau
openaire   +1 more source

Efflux Pump-mediated Drug Resistance in Burkholderia

Frontiers in Microbiology, 2015
Several members of the genus Burkholderia are prominent pathogens. Infections caused by these bacteria are difficult to treat because of significant antibiotic resistance.
Nicole L Podnecky, Katherine A Rhodes, Katherine A Rhodes, Herbert P Schweizer, Herbert P Schweizer   +4 more
doaj   +1 more source

Targeting and ultrabroad insight into molecular basis of Resistance-nodulation-cell division efflux pumps

Scientific Reports, 2022
Resistance-nodulation-cell devision (RND) efflux pump variants have attracted a great deal of attention for efflux of many antibiotic classes, which leads to multidrug-resistant bacteria.
Hooria Seyedhosseini Ghaheh, Mohammad Sadegh Damavandi, Parisa Sadeghi, Ahmad Reza Massah, Taravat Hamidi Asl, Azhar Salari-Jazi, Seyed Hossein Hejazi   +6 more
doaj   +1 more source

Enhanced strategies for cuproptosis‐like death in bacterial infection treatment

BMEMat, Volume 4, Issue 3, September 2026.
This review summarizes and examines the molecular mechanisms underlying cuproptosis‐like death. Furthermore, multi‐strategy efficacy enhancement and potential enhancement approaches are analyzed. Abstract Copper, a classical antibacterial metal, has long been of interest and widely used in medical and public health applications.
Wenqi Wang, Bolong Xu, Ruiyuan Zhu, Hengshuo Gui, Tian Xia, Shaokai Liu, Huiyu Liu, Xianwen Wang   +7 more
wiley   +1 more source