Results 61 to 70 of about 4,835 (134)

A microfluidic device for simple and rapid evaluation of multidrug efflux pump inhibitors

Frontiers in Microbiology, 2012
Recently, multidrug resistant pathogens have disseminated widely owing essentially to their increased multidrug efflux pump activity. Presently, there is a scarcity of new antibacterial agents, and hence, inhibitors of multidrug efflux pumps belonging to
Ryota eIino, Ryota eIino, Kunihiko eNishino, Hiroyuki eNoji, Hiroyuki eNoji, Akihito eYamaguchi, Akihito eYamaguchi, Yoshimi eMatsumoto   +7 more
doaj   +1 more source

Escherichia coli from Human Wounds: Analysis of Resistance to β-Lactams and Expression of RND Efflux Pumps. [PDF]

Infect Drug Resist, 2023
Rihacek M, Kuthanova M, Splichal Z, Adam V, Hrazdilova K, Vesely R, Zurek L, Cihalova K.   +7 more
europepmc   +1 more source

Combination Therapy with Ciprofloxacin and Pentamidine against Multidrug-Resistant Pseudomonas aeruginosa: Assessment of In Vitro and In Vivo Efficacy and the Role of Resistance-Nodulation-Division (RND) Efflux Pumps. [PDF]

Antibiotics (Basel), 2023
Fletcher M, McCormack A, Parcell BJ, Coote PJ.   +3 more
europepmc   +1 more source

Conformational plasticity across phylogenetic clusters of RND multidrug efflux pumps and its impact on substrate specificity

Nature Communications
Antibiotic efflux plays a key role for the multidrug resistance in Gram-negative bacteria. Multidrug efflux pumps of the resistance nodulation and cell division (RND) superfamily function as part of cell envelope spanning systems and provide resistance ...
Mariya Lazarova, Thomas Eicher, Clara Börnsen, Hui Zeng, Mohd Athar, Ui Okada, Eiki Yamashita, Inga M. Spannaus, Max Borgosch, Hi-jea Cha, Attilio V. Vargiu, Satoshi Murakami, Kay Diederichs, Achilleas S. Frangakis, Klaas M. Pos   +14 more
doaj   +1 more source

Fighting back against bacterial resistance: Harnessing nanocarrier strategies to counter antibiotic efflux pumps

Next Materials
The global rise of multidrug-resistant (MDR) bacterial infections poses a significant threat to public health, mainly driven by antibiotic efflux pumps that actively expel drugs from bacterial cells and lower intracellular antibiotic concentrations below
Kingsley Chimaeze Mbara, Yvonne Ngcobo, Betty Chivasa, Lethabo Masemola, Refilwe Mashamaite, Kopang Clemendi Mokhetho, Motsi Phuthi, Mandisa Mangisa, Poloko Stephen Kheoane, Shoeshoe Lydia Mokhele, Lorato Mmaoratwe Marakalala, Claudine Mbeb, Rosalinda Pepita Emeyene, Carmen Myrna Leonard, Vuyelwa Jacqueline Tembu, Clemence Tarirai   +15 more
doaj   +1 more source

Biofilm formation and polar lipid biosynthesis in Mycobacterium abscessus are inhibited by naphthylmethylpiperazine.

PLoS ONE
Mycobacterium abscessus is a biofilm-forming, non-tuberculous mycobacterium that is highly resistant to antibiotics. Bacterial efflux pumps contribute to biofilm formation, export of biofilm-associated lipids and antibiotic tolerance.
Timilehin Faboro, Jaiyanth Daniel
doaj   +1 more source

Evaluation of HP0605 and HP0971 genes of efflux pumps in Helicobacter pylori resistance to Metronidazole

Iranian South Medical Journal, 2009
Background: The presence of antibiotic resistance has been reported in H.pylori and it is a major cause of treatment failure. Five families of multidrug efflux pumps are defined in bacteria and resistance-nodulation-division (RND) pumps are found mainly ...
Mohammad hasan Shirazi, Mohammad Mehdi Soltan dalal, Sara Haji khani, Mohammad reza Pourmand, Jalil Fallah Mehrabadi, Naser Moghimi Dariaie, Mehrndokht Sirous, Seied Saeed Eshraghi   +7 more
doaj  

Influence of the rhizosphere on the expression of RND efflux pumps and the emergence of multidrug resistance

, 2023
Les pompes RND sont une superfamille de pompes à efflux, dont les trois familles principales, HAE-1, NFE et HME, expulsent des substrats spécifiques comme des molécules organiques ou des métaux. En particulier, les pompes de la famille HAE-1, sont un facteur important de multi-résistance aux antibiotiques chez bactéries opportunistes comme Pseudomonas ...
openaire   +1 more source

Structural modeling of RND family efflux pumps : From antibioresistance to chemotherapyresistance

Modélisation structurale des pompes à efflux de la famille des RND : de la résistance aux antibiotiques à la résistance à la chimiothérapie La résistance à la chimiothérapie peut-être étudiée comparativement à l’étude de la résistance chez les microorganismes.
openaire   +2 more sources

Medicinal Plants: A Promising Therapeutic Approach for Addressing Antimicrobial Resistance. [PDF]

Int J Mol Sci
Zhou H, Du J, Jia M, Li Y, Zheng K.
europepmc   +1 more source