Results 41 to 50 of about 4,835 (134)
Subfunctionalization influences the expansion of bacterial multidrug antibiotic resistance
BMC Genomics, 2017 Background Antibiotic resistance is a major problem for human health. Multidrug resistance efflux pumps, especially those of the Resistance-Nodulation-Cell Division (RND) family, are major contributors to high-level antibiotic resistance in Gram-negative
Elena Perrin +7 more
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Recent advances toward a molecular mechanism of efflux pump inhibition
Frontiers in Microbiology, 2015 Multi-drug resistance (MDR) in Gram-negative pathogens, such as the Enterobacteriaceae and Pseudomonas aeruginosa, poses a significant threat to our ability to effectively treat infections caused by these organisms.
Timothy J Opperman, Son T Nguyen
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Bacterial Resistance Toward Antimicrobial Ionic Liquids Mediated by Multidrug Efflux Pumps
Frontiers in Microbiology, 2022 The effective elimination of foodborne pathogens through cleaning and disinfection measures is of great importance to the food processing industry. As food producers rely heavily on disinfectants to control pathogenic bacteria in their facilities, the ...
Tobias Gundolf +5 more
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Role of efflux pumps in reduced susceptibility to tigecycline in Acinetobacter baumannii
New Microbes and New Infections, 2019 Acinetobacter baumannii is an important human pathogen responsible for a various type of infections. These bacterial strains are generally resistant to numerous antibiotics.
S.H. Ardehali +5 more
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Crystal structure of the Neisseria gonorrhoeae MtrD inner membrane multidrug efflux pump. [PDF]
PLoS ONE, 2014 Neisseria gonorrhoeae is an obligate human pathogen and the causative agent of the sexually-transmitted disease gonorrhea. The control of this disease has been compromised by the increasing proportion of infections due to antibiotic-resistant strains ...
Jani Reddy Bolla +11 more
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RND family efflux pumps: from antibioresistance to chemotherapy resistance
Swedish Journal of BioScience Research, 2020 Resistance to chemotherapy can be studied comparatively to the study of resistance in microorganisms. For over 40 years, understanding mechanisms that confer MDR has been a major goal of cancer biologists. Most of the studies toward MDR in cancer cells were about ABC transporters.
Méliné Simsir, Isabelle Mus-Veteau
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Journal of Infection in Developing Countries, 2010 Introduction: Metronidazole is a significant antibiotic used for eradication of Helicobactor pylori infections and it is of notice that metronidazole-resistant clinical isolates have been found in high rates worldwide.
Jalil Fallah Mehrabadi +5 more
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Frontiers in Microbiology, 2022 Genetic alterations leading to the constitutive upregulation of specific efflux pumps contribute to antibacterial resistance in multidrug resistant bacteria.
Mireia López-Siles +2 more
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Efflux Pump-mediated Drug Resistance in Burkholderia
Frontiers in Microbiology, 2015 Several members of the genus Burkholderia are prominent pathogens. Infections caused by these bacteria are difficult to treat because of significant antibiotic resistance.
Nicole L Podnecky +4 more
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First Description of an RND-Type Multidrug Efflux Pump in Achromobacter xylosoxidans, AxyABM [PDF]
Antimicrobial Agents and Chemotherapy, 2011 ABSTRACT Achromobacter xylosoxidans is an emerging pathogen in cystic fibrosis patients. The multidrug resistance of these bacteria remains poorly understood. We have characterized in a clinical strain the first resistance-nodulation-cell division (RND)-type multidrug efflux pump in this species: AxyABM.
Bador, Julien +6 more
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