Results 41 to 50 of about 179,366 (172)

Optimization of a novel series of pyranopyridine RND efflux pump inhibitors [PDF]

Current Opinion in Microbiology, 2016
The rise of multidrug resistant (MDR) Gram-negative pathogens complicates our ability to treat bacterial infections with antibiotics. MDR efflux pumps play a major role in the acquisition and expression of the MDR phenotype. The major MDR efflux pumps in Gram-negative pathogens are the resistance-nodulation-division (RND) superfamily pumps. Efflux pump
Zachary Aron, Timothy J Opperman
openaire   +2 more sources

Assessment of three Resistance-Nodulation-Cell Division drug efflux transporters of Burkholderia cenocepacia in intrinsic antibiotic resistance

BMC Microbiology, 2009
Background Burkholderia cenocepacia are opportunistic Gram-negative bacteria that can cause chronic pulmonary infections in patients with cystic fibrosis.
Venturi Vittorio, Bertani Iris, Milano Anna, Bazzini Silvia, Flannagan Ronald S, Pasca Maria R, Buroni Silvia, Valvano Miguel A, Riccardi Giovanna   +8 more
doaj   +1 more source

A linkage between SmeIJK efflux pump, cell envelope integrity, and σE-mediated envelope stress response in Stenotrophomonas maltophilia. [PDF]

PLoS ONE, 2014
Resistance nodulation division (RND) efflux pumps, such as the SmeIJK pump of Stenotrophomonas maltophilia, are known to contribute to the multidrug resistance in Gram-negative bacteria. However, some RND pumps are constitutively expressed even though no
Yi-Wei Huang, Rung-Shiuan Liou, Yi-Tsung Lin, Hsin-Hui Huang, Tsuey-Ching Yang   +4 more
doaj   +1 more source

Over-Expression of Hypochlorite Inducible Major Facilitator Superfamily (MFS) Pumps Reduces Antimicrobial Drug Susceptibility by Increasing the Production of MexXY Mediated by ArmZ in Pseudomonas aeruginosa

Frontiers in Microbiology, 2021
Pseudomonas aeruginosa, a well-known cause of nosocomial infection, is frequently antibiotic resistant and this complicates treatment. Links between oxidative stress responses inducing antibiotic resistance through over-production of RND-type efflux ...
Punyawee Dulyayangkul, Punyawee Dulyayangkul, Naphat Satapoomin, Matthew B. Avison, Nisanart Charoenlap, Paiboon Vattanaviboon, Paiboon Vattanaviboon, Skorn Mongkolsuk   +7 more
doaj   +1 more source

Drug Efflux Pump Inhibitors: A Promising Approach to Counter Multidrug Resistance in Gram-Negative Pathogens by Targeting AcrB Protein from AcrAB-TolC Multidrug Efflux Pump from Escherichia coli

Biology, 2022
Infections caused by multidrug resistance (MDR) of Gram-negative bacteria have become one of the most severe public health problems worldwide. The main mechanism that confers MDR to bacteria is drug efflux pumps, as they expel a wide range of compounds ...
Rawaf Alenazy
doaj   +1 more source

Acinetobacter baumannii Survival under Infection-Associated Stresses Depends on the Expression of Resistance–Nodulation–Division and Major Facilitator Superfamily Efflux Pumps

Antibiotics, 2023
Multidrug efflux transporters are major contributors to the antibiotic resistance of Acinetobacter baumannii in clinical settings. Previous studies showed that these transporters are tightly integrated into the physiology of A. baumannii and have diverse
Inga V. Leus, Marcela Olvera, Justyna W. Adamiak, Lauren L. Nguyen, Helen I. Zgurskaya   +4 more
doaj   +1 more source

An RND-type multidrug efflux pump SdeXY from Serratia marcescens [PDF]

Journal of Antimicrobial Chemotherapy, 2003
Serratia marcescens, an important cause of nosocomial infections, shows intrinsic resistance to a wide variety of antimicrobial agents (multidrug resistance). Multidrug efflux pumps are often involved in the multidrug resistance in many bacteria. A study was undertaken to characterize the multidrug efflux pumps in S.
Jing, Chen, Teruo, Kuroda, Md Nazmul, Huda, Tohru, Mizushima, Tomofusa, Tsuchiya   +4 more
openaire   +2 more sources

Subfunctionalization influences the expansion of bacterial multidrug antibiotic resistance

BMC Genomics, 2017
Background Antibiotic resistance is a major problem for human health. Multidrug resistance efflux pumps, especially those of the Resistance-Nodulation-Cell Division (RND) family, are major contributors to high-level antibiotic resistance in Gram-negative
Elena Perrin, Marco Fondi, Emanuele Bosi, Alessio Mengoni, Silvia Buroni, Viola Camilla Scoffone, Miguel Valvano, Renato Fani   +7 more
doaj   +1 more source

Identification of three outer membrane channels of RND efflux pumps.

, 2013
Identification of three outer membrane channels of RND efflux pumps.
Thomas Poyot (135820), Andre Peinnequin (5657299), Jean-Marie Pagès (69129), Arnaud Caclard (502569), François Michel Thibault (502570), Mélanie Monique Lopez (502567), Eric Valade (356355), Fabienne Neulat-Ripoll (502568), Fabrice Vincent Biot (502566), Sabrina Lignon (258760)   +9 more
core   +1 more source

Recent advances toward a molecular mechanism of efflux pump inhibition

Frontiers in Microbiology, 2015
Multi-drug resistance (MDR) in Gram-negative pathogens, such as the Enterobacteriaceae and Pseudomonas aeruginosa, poses a significant threat to our ability to effectively treat infections caused by these organisms.
Timothy J Opperman, Son T Nguyen
doaj   +1 more source