Results 21 to 30 of about 4,835 (134)

Erratum for Leus et al., "Substrate Specificities and Efflux Efficiencies of RND Efflux Pumps of Acinetobacter baumannii". [PDF]

J Bacteriol, 2020
Volume 200, no. 13, e00049-18, 2018, [https://doi.org/10.1128/JB.00049-18][1]. Page 7, Table 2, lines 4–2 from bottom, AbΔ3 columns: For CF, “0.01” and “0.01” should read “8–16” and “Not determined,” respectively; for TRI, “0.78–1.56” and “0.78” should read “0.01”
Leus IV, Weeks JW, Bonifay V, Smith L, Richardson S, Zgurskaya HI.   +5 more
europepmc   +4 more sources

Vibrio cholerae VexH encodes a multiple drug efflux pump that contributes to the production of cholera toxin and the toxin co-regulated pilus. [PDF]

PLoS ONE, 2012
The resistance-nodulation-division (RND) efflux systems are ubiquitous transporters that function in antimicrobial resistance. Recent studies showed that RND systems were required for virulence factor production in Vibrio cholerae. The V. cholerae genome
Dawn L Taylor, Xiaowen R Bina, James E Bina   +2 more
doaj   +1 more source

Mechanisms of RND multidrug efflux pumps [PDF]

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2009
RND (Resistance-Nodulation-Division) family transporters are widespread especially among Gram-negative bacteria, and catalyze the active efflux of many antibiotics and chemotherapeutic agents. They have very large periplasmic domains, and form tripartite complexes with outer membrane channels and periplasmic adaptor proteins.
Hiroshi, Nikaido, Yumiko, Takatsuka
openaire   +2 more sources

Evaluation of Delafloxacin against a Burkholderia pseudomallei Efflux Mutant Panel

Microbiology Spectrum, 2022
In vitro activities of delafloxacin and ciprofloxacin were evaluated against Burkholderia pseudomallei mutants expressing or lacking defined resistance-nodulation-cell division (RND) efflux pumps using CLSI methodology at pHs of 5.8 and 7.2. Delafloxacin
Sandra P. McCurdy, Nawarat Somprasong, Herbert P. Schweizer   +2 more
doaj   +1 more source

Molecular insights into the determinants of substrate specificity and efflux inhibition of the RND efflux pumps AcrB and AdeB. [PDF]

Microbiology (Reading)
Gram-negative bacterial members of the Resistance Nodulation and cell Division (RND) superfamily form tripartite efflux pump systems that span the cell envelope. One of the intriguing features of the multiple drug efflux members of this superfamily is their ability to recognize different classes of antibiotics, dyes, solvents, bile salts, and ...
Wilhelm J, Pos KM.
europepmc   +3 more sources

Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps [PDF]

Nature Communications, 2022
AbstractEfflux transporters of the RND family confer resistance to multiple antibiotics in Gram-negative bacteria. Here, we identify and chemically optimize pyridylpiperazine-based compounds that potentiate antibiotic activity in E. coli through inhibition of its primary RND transporter, AcrAB-TolC. Characterisation of resistant E.
Plé, Coline, Tam, Heng-Keat, Vieira da Cruz, Anais, Compagne, Nina, Jiménez-Castellanos, Juan-Carlos, Müller, Reinke, Pradel, Elizabeth, Foong, Wuen Ee, Malloci, Giuliano, Ballée, Alexia, Kirchner, Moritz, Moshfegh, Parisa, Herledan, Adrien, Herrmann, Andrea, Deprez, Benoit, Willand, Nicolas, Vargiu, Attilio Vittorio, Pos, Klaas, Flipo, Marion, Hartkoorn, Ruben   +19 more
openaire   +4 more sources

Deciphering the role of RND efflux transporters in Burkholderia cenocepacia. [PDF]

PLoS ONE, 2011
Burkholderia cenocepacia J2315 is representative of a highly problematic group of cystic fibrosis (CF) pathogens. Eradication of B. cenocepacia is very difficult with the antimicrobial therapy being ineffective due to its high resistance to clinically ...
Silvia Bazzini, Claudia Udine, Andrea Sass, Maria Rosalia Pasca, Francesca Longo, Giovanni Emiliani, Marco Fondi, Elena Perrin, Francesca Decorosi, Carlo Viti, Luciana Giovannetti, Livia Leoni, Renato Fani, Giovanna Riccardi, Eshwar Mahenthiralingam, Silvia Buroni   +15 more
doaj   +1 more source

Structural Basis of Peptide-Based Antimicrobial Inhibition of a Resistance-Nodulation-Cell Division Multidrug Efflux Pump

Microbiology Spectrum, 2022
Bacterial efflux pumps in the resistance-nodulation-cell division (RND) family of Gram-negative bacteria contribute significantly to the development of antimicrobial resistance by many pathogens. In this study, we selected the MtrD transporter protein of
Meinan Lyu, Julio C. Ayala, Isabella Chirakos, Chih-Chia Su, William M. Shafer, Edward W. Yu   +5 more
doaj   +1 more source

Characteristics and diversity of mutations in regulatory genes of resistance-nodulation-cell division efflux pumps in association with drug-resistant clinical isolates of Acinetobacter baumannii

Antimicrobial Resistance and Infection Control, 2021
Background This study was aimed to characterize the genetic diversity and expression of three putative resistance-nodulation-cell division (RND)-type efflux systems and their contribution to multidrug efflux in clinical isolates of Acinetobacter ...
Bahare Salehi, Zohreh Ghalavand, Abbas Yadegar, Gita Eslami   +3 more
doaj   +1 more source

Optimization of a novel series of pyranopyridine RND efflux pump inhibitors [PDF]

Current Opinion in Microbiology, 2016
The rise of multidrug resistant (MDR) Gram-negative pathogens complicates our ability to treat bacterial infections with antibiotics. MDR efflux pumps play a major role in the acquisition and expression of the MDR phenotype. The major MDR efflux pumps in Gram-negative pathogens are the resistance-nodulation-division (RND) superfamily pumps. Efflux pump
Zachary Aron, Timothy J Opperman
openaire   +2 more sources