Resistance-Nodulation-Division Multidrug Efflux Pumps in Gram-Negative Bacteria: Role in Virulence
Antibiotics, 2013 Resistance-Nodulation-Division (RND) efflux pumps are one of the most important determinants of multidrug resistance (MDR) in Gram-negative bacteria. With an ever increasing number of Gram-negative clinical isolates exhibiting MDR phenotypes as a result ...
Ayush Kumar, Dinesh M. Fernando
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The role of RND-type efflux pumps in multidrug-resistant mutants of Klebsiella pneumoniae [PDF]
Scientific Reports, 2020 The emergence of multidrug-resistant Klebsiella pneumoniae is a worldwide problem. K. pneumoniae possesses numerous resistant genes in its genome.
Mizusawa, Minako +8 more
core +6 more sources
Seasonal Restructuring of Microbial Communities and Resistomes in the Shitalakshya River, Bangladesh Revealed by Shotgun Metagenomics. [PDF]
MicrobiologyopenDry‐season pollutant concentration drives microbial restructuring in Bangladesh's Shitalakshya River, shifting communities from Myroides to stress‐tolerant genera while enriching metal resistance genes and efflux pumps, revealing non‐antibiotic co‐selection as a key driver of antimicrobial resistance in urban waters.
Haque ME, Rahman MS, Sultana M, Begum A.
europepmc +2 more sources
A role for the periplasmic adaptor protein AcrA in vetting substrate access to the RND efflux transporter AcrB [PDF]
Scientific Reports, 2022 Tripartite resistance-nodulation-division (RND) efflux pumps, such as AcrAB-TolC of Salmonella Typhimurium, contribute to antibiotic resistance and comprise an inner membrane RND-transporter, an outer membrane factor, and a periplasmic adaptor protein ...
Ilyas Alav +2 more
doaj +2 more sources
RND efflux pumps: structural information translated into function and inhibition mechanisms
Current Topics in Medicinal Chemistry, 2013 Efflux pumps of the Resistance Nodulation Division (RND) superfamily play a major role in the intrinsic and acquired resistance of Gram-negative pathogens to antibiotics. Moreover, they are largely responsible for multi-drug resistance (MDR) phenomena in
VARGIU, ATTILIO VITTORIO +3 more
core +4 more sources
Conformational plasticity across phylogenetic clusters of RND multidrug efflux pumps and its impact on substrate specificity [PDF]
Nature CommunicationsAntibiotic efflux plays a key role for the multidrug resistance in Gram-negative bacteria. Multidrug efflux pumps of the resistance nodulation and cell division (RND) superfamily function as part of cell envelope spanning systems and provide resistance ...
Mariya Lazarova +14 more
doaj +2 more sources
Beyond antibiotic resistance: evidence for resistance-nodulation-division (RND) efflux pumps as virulence determinants [PDF]
Microbiology and Molecular Biology ReviewsIlyas Alav, Corrella Detweiler
exaly +2 more sources
The ins and outs of RND efflux pumps in Escherichia coli. [PDF]
Front Microbiol, 2015 Infectious diseases remain one of the principal causes of morbidity and mortality in the world. Relevant authorities including the WHO and CDC have expressed serious concern regarding the continued increase in the development of multidrug resistance among bacteria.
Anes J +3 more
europepmc +5 more sources
RND multidrug efflux pumps: what are they good for? [PDF]
Frontiers in Microbiology, 2013 Multidrug efflux pumps are chromosomally encoded genetic elements capable of mediating resistance to toxic compounds in several life forms. In bacteria, these elements are involved in intrinsic and acquired resistance to antibiotics. Unlike other well-known horizontally acquired antibiotic resistance determinants, genes encoding for multidrug efflux ...
Alvarez-Ortega, Carolina +2 more
openaire +5 more sources
Differential roles of RND efflux pumps in antimicrobial drug resistance of sessile and planktonic Burkholderia cenocepacia cells. [PDF]
Antimicrob Agents Chemother, 2014 Burkholderia cenocepacia is notorious for causing respiratory tract infections in people with cystic fibrosis. Infections with this organism are particularly difficult to treat due to its high level of intrinsic resistance to most antibiotics.
Buroni S +7 more
europepmc +3 more sources