Role of RND Efflux Pumps in Drug Resistance of Cystic Fibrosis Pathogens [PDF]
Antibiotics, 2021 Drug resistance represents a great concern among people with cystic fibrosis (CF), due to the recurrent and prolonged antibiotic therapy they should often undergo.
Viola Camilla Scoffone +2 more
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Ever-Adapting RND Efflux Pumps in Gram-Negative Multidrug-Resistant Pathogens: A Race against Time [PDF]
Antibiotics, 2021 The rise in multidrug resistance (MDR) is one of the greatest threats to human health worldwide. MDR in bacterial pathogens is a major challenge in healthcare, as bacterial infections are becoming untreatable by commercially available antibiotics. One of
Martijn Zwama +2 more
exaly +4 more sources
Versatility of Stenotrophomonas maltophilia: Ecological roles of RND efflux pumps [PDF]
Heliyon, 2023 S. maltophilia is a widely distributed bacterium found in natural, anthropized and clinical environments. The genome of this opportunistic pathogen of environmental origin includes a large number of genes encoding RND efflux pumps independently of the ...
Amandine Chauviat +2 more
doaj +2 more sources
Functional interplay between RND efflux pumps and GacS in Pseudomonas aeruginosa [PDF]
Applied and Environmental MicrobiologyPseudomonas aeruginosa is an opportunistic human pathogen that is ubiquitous in the environment. The environmental versatility of P. aeruginosa is often attributed to a large arsenal of active efflux pumps, low permeability of the outer membrane, and ...
Justyna W. Adamiak +6 more
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How resistance-nodulation-division (RND) efflux pumps contribute to virulence. [PDF]
PLoS PathogensIn Gram-negative bacteria, multi-subunit efflux pumps transport molecules across the inner membrane, periplasm, and outer membrane to the extracellular environment.
Corrella S Detweiler, Ilyas Alav
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Identification of oxyresveratrol, a food-as-medicine substrate, as a novel EPI that targets the RND efflux pumps of Serratia surfactantfaciens sp. nov. YD25T [PDF]
Microbiology SpectrumSerratia marcescens is an opportunistic pathogen with increasing drug resistance. Serratia surfactantfaciens sp. nov. YD25T, a novel strain with multidrug resistance, shares similarities with S. marcescens.
Fuqiao Liu +8 more
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Identification of binding residues between periplasmic adapter protein (PAP) and RND efflux pumps explains PAP-pump promiscuity and roles in antimicrobial resistance. [PDF]
PLoS Pathogens, 2019 Active efflux due to tripartite RND efflux pumps is an important mechanism of clinically relevant antibiotic resistance in Gram-negative bacteria. These pumps are also essential for Gram-negative pathogens to cause infection and form biofilms.
Helen E McNeil +11 more
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Interaction of antibacterial compounds with RND efflux pumps in Pseudomonas aeruginosa [PDF]
Frontiers in Microbiology, 2015 Pseudomonas aeruginosa infections are becoming increasingly difficult to treat due to intrinsic antibiotic resistance and the propensity of this pathogen to accumulate diverse resistance mechanisms.
Juerg eDreier, Paolo eRuggerone
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Exploring allosteric efflux pump inhibitors and the role of bacterial membrane potential in modulating drug resistance [PDF]
Frontiers in MicrobiologyMulti-drug resistance (MDR) bacteria pose a significant global health challenge, primarily driven by the activity of multi-drug efflux pumps and their intimate coupling to bacterial membrane bioenergetics.
Ajay Pratap Singh Hada +5 more
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Cryo-EM reveals the structural heterogeneity and conformational flexibility of multidrug efflux pumps MdtB and MdtF [PDF]
mBioResistance-nodulation-cell division (RND) efflux pumps are the major cause of multidrug resistance in bacteria, particularly in Gram-negative bacteria. They are complex molecular machines forming tripartite assemblies that actively transport out a wide ...
Surekha Padmanaban +3 more
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