Results 11 to 20 of about 4,835 (134)
The hydrophobic trap—the Achilles heel of RND efflux pumps [PDF]
Research in Microbiology, 2018 Resistance-nodulation-division (RND) superfamily efflux pumps play a major role in multidrug resistance (MDR) of Gram-negative pathogens by extruding diverse classes of antibiotics from the cell. There has been considerable interest in developing efflux pump inhibitors (EPIs) of RND pumps as adjunctive therapies.
Zachary D Aron, Timothy J Opperman
exaly +5 more sources
The RND Efflux Pump Gene Expression in the Biofilm Formation of Acinetobacter baumannii
Antibiotics, 2023 Multidrug resistant (MDR) Acinetobacter baumannii is a critical opportunistic pathogen in healthcare-associated infections (HAI). This is attributed to several factors, including its ability to develop biofilms that can enhance antimicrobial resistance ...
Ola A. Abd El-Rahman +4 more
doaj +3 more sources
Antibiotics, 2022 Bacterial efflux pumps are among the key mechanisms of resistance against antibiotics and biocides. We investigated whether differential expression levels of the RND-type efflux pumps AdeABC and AdeIJK impacted the susceptibility to commonly used ...
Christina Meyer +6 more
doaj +3 more sources
Tripartite assembly of RND multidrug efflux pumps [PDF]
Nature Communications, 2016 Tripartite efflux systems consist of inner membrane, outer membrane and periplasmic components. Here, Daury et al. reconstitute native versions of RND transporters in nanodiscs and present projection structures emphasizing the role of the periplasmic ...
Laetitia Daury +10 more
doaj +4 more sources
MOLECULAR DYNAMICS COMPUTER SIMULATIONS OF MULTIDRUG RND EFFLUX PUMPS
Computational and Structural Biotechnology Journal, 2013 Over-expression of multidrug efflux pumps of the Resistance Nodulation Division (RND) protein super family counts among the main causes for microbial resistance against pharmaceuticals.
Paolo Ruggerone +4 more
doaj +5 more sources
Comprehensive analysis of resistance-nodulation-cell division superfamily (RND) efflux pumps from Serratia marcescens, Db10 [PDF]
Scientific Reports, 2019 We investigated the role of the resistance-nodulation-cell division superfamily (RND) efflux system on intrinsic multidrug resistance in Serratia marcescens. We identified eight putative RND efflux system genes in the S.
Shinsuke Toba +12 more
doaj +2 more sources
Substrate Specificities and Efflux Efficiencies of RND Efflux Pumps of Acinetobacter baumannii. [PDF]
J Bacteriol, 2018 ABSTRACT Antibiotic-resistant Acinetobacter baumannii causes infections that are extremely difficult to treat. A significant role in these resistance profiles is attributed to multidrug efflux pumps, especially those belonging to the resistance-nodulation-cell division (RND) superfamily of transporters. In
Leus IV +5 more
europepmc +4 more sources
The ins and outs of RND efflux pumps in Escherichia coli. [PDF]
Front Microbiol, 2015 Infectious diseases remain one of the principal causes of morbidity and mortality in the world. Relevant authorities including the WHO and CDC have expressed serious concern regarding the continued increase in the development of multidrug resistance among bacteria.
Anes J +3 more
europepmc +5 more sources
Beyond antibiotic resistance: evidence for resistance-nodulation-division (RND) efflux pumps as virulence determinants [PDF]
Microbiology and Molecular Biology ReviewsCorrella S Detweiler, Ilyas Alav
exaly +2 more sources
RND multidrug efflux pumps: what are they good for? [PDF]
Frontiers in Microbiology, 2013 Multidrug efflux pumps are chromosomally encoded genetic elements capable of mediating resistance to toxic compounds in several life forms. In bacteria, these elements are involved in intrinsic and acquired resistance to antibiotics. Unlike other well-known horizontally acquired antibiotic resistance determinants, genes encoding for multidrug efflux ...
Alvarez-Ortega, Carolina +2 more
openaire +5 more sources