Results 11 to 20 of about 179,366 (172)
MOLECULAR DYNAMICS COMPUTER SIMULATIONS OF MULTIDRUG RND EFFLUX PUMPS [PDF]
Computational and Structural Biotechnology Journal, 2013 Over-expression of multidrug efflux pumps of the Resistance Nodulation Division (RND) protein super family counts among the main causes for microbial resistance against pharmaceuticals.
Paolo Ruggerone +4 more
doaj +6 more sources
Antibiotics, 2022 Bacterial efflux pumps are among the key mechanisms of resistance against antibiotics and biocides. We investigated whether differential expression levels of the RND-type efflux pumps AdeABC and AdeIJK impacted the susceptibility to commonly used ...
Christina Meyer +6 more
doaj +4 more sources
The hydrophobic trap—the Achilles heel of RND efflux pumps [PDF]
Research in Microbiology, 2018 Resistance-nodulation-division (RND) superfamily efflux pumps play a major role in multidrug resistance (MDR) of Gram-negative pathogens by extruding diverse classes of antibiotics from the cell. There has been considerable interest in developing efflux pump inhibitors (EPIs) of RND pumps as adjunctive therapies.
Zachary D. Aron, Timothy J Opperman
exaly +5 more sources
Substrate Specificities and Efflux Efficiencies of RND Efflux Pumps of Acinetobacter baumannii. [PDF]
J Bacteriol, 2018 Antibiotic-resistant Acinetobacter baumannii causes infections that are extremely difficult to treat. A significant role in these resistance profiles is attributed to multidrug efflux pumps, especially those belonging to the ...
Leus IV +5 more
europepmc +5 more sources
Resistance in gram-negative bacilli: the emergence of RND efflux pumps [PDF]
Future MicrobiologyThe rise of antimicrobial resistance has been a significant problem in recent decades, decreasing the effectiveness of antibiotics and making the treatment of infections increasingly difficult. This phenomenon can be acquired through various mechanisms, with antibiotic efflux mediated by proteins known as efflux pumps being one of the most important ...
Caio Augusto Martins Aires +2 more
exaly +4 more sources
Molecular insights into the determinants of substrate specificity and efflux inhibition of the RND efflux pumps AcrB and AdeB [PDF]
Microbiology (United Kingdom)Gram-negative bacterial members of the Resistance Nodulation and cell Division (RND) superfamily form tripartite efflux pump systems that span the cell envelope. One of the intriguing features of the multiple drug efflux members of this superfamily is their ability to recognize different classes of antibiotics, dyes, solvents, bile salts, and ...
Klaas M Pos
exaly +4 more sources
Deciphering the role of RND efflux transporters in Burkholderia cenocepacia. [PDF]
PLoS ONE, 2011 Burkholderia cenocepacia J2315 is representative of a highly problematic group of cystic fibrosis (CF) pathogens. Eradication of B. cenocepacia is very difficult with the antimicrobial therapy being ineffective due to its high resistance to clinically ...
Silvia Bazzini +15 more
doaj +3 more sources
The RND Efflux Pump Gene Expression in the Biofilm Formation of Acinetobacter baumannii
Antibiotics, 2023 Multidrug resistant (MDR) Acinetobacter baumannii is a critical opportunistic pathogen in healthcare-associated infections (HAI). This is attributed to several factors, including its ability to develop biofilms that can enhance antimicrobial resistance ...
Ola A. Abd El-Rahman +4 more
doaj +3 more sources
Tripartite assembly of RND multidrug efflux pumps [PDF]
Nature Communications, 2016 Tripartite efflux systems consist of inner membrane, outer membrane and periplasmic components. Here, Daury et al. reconstitute native versions of RND transporters in nanodiscs and present projection structures emphasizing the role of the periplasmic ...
Laetitia Daury +10 more
doaj +4 more sources
Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps [PDF]
Nature Communications, 2022 Efflux transporters of the RND family confer resistance to multiple antibiotics in Gram-negative bacteria. Here, we identify and chemically optimize pyridylpiperazine-based compounds that potentiate antibiotic activity in E.
Compagne N. +61 more
core +6 more sources