Results 31 to 40 of about 4,835 (134)

Assessment of three Resistance-Nodulation-Cell Division drug efflux transporters of Burkholderia cenocepacia in intrinsic antibiotic resistance

BMC Microbiology, 2009
Background Burkholderia cenocepacia are opportunistic Gram-negative bacteria that can cause chronic pulmonary infections in patients with cystic fibrosis.
Venturi Vittorio, Bertani Iris, Milano Anna, Bazzini Silvia, Flannagan Ronald S, Pasca Maria R, Buroni Silvia, Valvano Miguel A, Riccardi Giovanna   +8 more
doaj   +1 more source

Alternative Model for RND-Type Efflux Pump

Journal of the Brazilian Chemical Society, 2016
RND (resistance-nodulation-division) transporters are found in several Gram-negative bacteria species. These proteins form a complex along with membrane fusion proteins and outer membrane factors. This complex acts as an efflux pump, transporting several different molecules directly from the cytoplasm to the extracellular medium.
Torres, Pedro Henrique Monteiro, Pascutti, Pedro Geraldo, Bisch, Paulo Mascarello, Silva, Manuela Leal da   +3 more
openaire   +4 more sources

Resistance-Nodulation-Division Multidrug Efflux Pumps in Gram-Negative Bacteria: Role in Virulence

Antibiotics, 2013
Resistance-Nodulation-Division (RND) efflux pumps are one of the most important determinants of multidrug resistance (MDR) in Gram-negative bacteria. With an ever increasing number of Gram-negative clinical isolates exhibiting MDR phenotypes as a result ...
Ayush Kumar, Dinesh M. Fernando
doaj   +1 more source

An RND-type multidrug efflux pump SdeXY from Serratia marcescens [PDF]

Journal of Antimicrobial Chemotherapy, 2003
Serratia marcescens, an important cause of nosocomial infections, shows intrinsic resistance to a wide variety of antimicrobial agents (multidrug resistance). Multidrug efflux pumps are often involved in the multidrug resistance in many bacteria. A study was undertaken to characterize the multidrug efflux pumps in S.
Jing, Chen, Teruo, Kuroda, Md Nazmul, Huda, Tohru, Mizushima, Tomofusa, Tsuchiya   +4 more
openaire   +2 more sources

A linkage between SmeIJK efflux pump, cell envelope integrity, and σE-mediated envelope stress response in Stenotrophomonas maltophilia. [PDF]

PLoS ONE, 2014
Resistance nodulation division (RND) efflux pumps, such as the SmeIJK pump of Stenotrophomonas maltophilia, are known to contribute to the multidrug resistance in Gram-negative bacteria. However, some RND pumps are constitutively expressed even though no
Yi-Wei Huang, Rung-Shiuan Liou, Yi-Tsung Lin, Hsin-Hui Huang, Tsuey-Ching Yang   +4 more
doaj   +1 more source

Over-Expression of Hypochlorite Inducible Major Facilitator Superfamily (MFS) Pumps Reduces Antimicrobial Drug Susceptibility by Increasing the Production of MexXY Mediated by ArmZ in Pseudomonas aeruginosa

Frontiers in Microbiology, 2021
Pseudomonas aeruginosa, a well-known cause of nosocomial infection, is frequently antibiotic resistant and this complicates treatment. Links between oxidative stress responses inducing antibiotic resistance through over-production of RND-type efflux ...
Punyawee Dulyayangkul, Punyawee Dulyayangkul, Naphat Satapoomin, Matthew B. Avison, Nisanart Charoenlap, Paiboon Vattanaviboon, Paiboon Vattanaviboon, Skorn Mongkolsuk   +7 more
doaj   +1 more source

A role for the periplasmic adaptor protein AcrA in vetting substrate access to the RND efflux transporter AcrB

Scientific Reports, 2022
Tripartite resistance-nodulation-division (RND) efflux pumps, such as AcrAB-TolC of Salmonella Typhimurium, contribute to antibiotic resistance and comprise an inner membrane RND-transporter, an outer membrane factor, and a periplasmic adaptor protein ...
Ilyas Alav, Vassiliy N. Bavro, Jessica M. A. Blair   +2 more
doaj   +1 more source

Drug Efflux Pump Inhibitors: A Promising Approach to Counter Multidrug Resistance in Gram-Negative Pathogens by Targeting AcrB Protein from AcrAB-TolC Multidrug Efflux Pump from Escherichia coli

Biology, 2022
Infections caused by multidrug resistance (MDR) of Gram-negative bacteria have become one of the most severe public health problems worldwide. The main mechanism that confers MDR to bacteria is drug efflux pumps, as they expel a wide range of compounds ...
Rawaf Alenazy
doaj   +1 more source

The role of RND-type efflux pumps in multidrug-resistant mutants of Klebsiella pneumoniae [PDF]

Scientific Reports, 2020
AbstractThe emergence of multidrug-resistant Klebsiella pneumoniae is a worldwide problem. K. pneumoniae possesses numerous resistant genes in its genome. We isolated mutants resistant to various antimicrobials in vitro and investigated the importance of intrinsic genes in acquired resistance. The isolation frequency of the mutants was 10−7–10−9.
Ni, Rui Ting, Onishi, Motoyasu, Mizusawa, Minako, Kitagawa, Ryoko, Kishino, Takanori, Matsubara, Futoshi, Tsuchiya, Tomofusa, Kuroda, Teruo, Ogawa, Wakano   +8 more
openaire   +3 more sources

Acinetobacter baumannii Survival under Infection-Associated Stresses Depends on the Expression of Resistance–Nodulation–Division and Major Facilitator Superfamily Efflux Pumps

Antibiotics, 2023
Multidrug efflux transporters are major contributors to the antibiotic resistance of Acinetobacter baumannii in clinical settings. Previous studies showed that these transporters are tightly integrated into the physiology of A. baumannii and have diverse
Inga V. Leus, Marcela Olvera, Justyna W. Adamiak, Lauren L. Nguyen, Helen I. Zgurskaya   +4 more
doaj   +1 more source