Results 31 to 40 of about 179,366 (172)

Mechanisms of RND multidrug efflux pumps [PDF]

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2009
RND (Resistance-Nodulation-Division) family transporters are widespread especially among Gram-negative bacteria, and catalyze the active efflux of many antibiotics and chemotherapeutic agents. They have very large periplasmic domains, and form tripartite complexes with outer membrane channels and periplasmic adaptor proteins.
Hiroshi, Nikaido, Yumiko, Takatsuka
openaire   +2 more sources

Vibrio cholerae VexH encodes a multiple drug efflux pump that contributes to the production of cholera toxin and the toxin co-regulated pilus. [PDF]

PLoS ONE, 2012
The resistance-nodulation-division (RND) efflux systems are ubiquitous transporters that function in antimicrobial resistance. Recent studies showed that RND systems were required for virulence factor production in Vibrio cholerae. The V. cholerae genome
Dawn L Taylor, Xiaowen R Bina, James E Bina   +2 more
doaj   +1 more source

Erratum for Leus et al., "Substrate Specificities and Efflux Efficiencies of RND Efflux Pumps of Acinetobacter baumannii". [PDF]

J Bacteriol, 2020
Volume 200, no. 13, e00049-18, 2018, [https://doi.org/10.1128/JB.00049-18][1]. Page 7, Table 2, lines 4–2 from bottom, AbΔ3 columns: For CF, “0.01” and “0.01” should read “8–16” and “Not determined,” respectively; for TRI, “0.78–1.56” and “0.78” should read “0.01”
Leus IV, Weeks JW, Bonifay V, Smith L, Richardson S, Zgurskaya HI.   +5 more
europepmc   +4 more sources

Evolution of RND efflux pumps in the development of a successful pathogen

Drug Resistance Updates, 2023
This study examined the origins and evolution of the AdeABC, AdeFGH and AdeIJK efflux pumps in the Acinetobacter genus, including human and animal pathogens and species from non-clinical environments.Comparative genome analyses were performed using the reference sequences for 70 Acinetobacter species to identify putative orthologs of AdeABC, AdeFGH and
Naidu, Varsha, Bartczak, Amelia, Brzoska, Anthony J., Lewis, Peter, Eijkelkamp, Bart A., Paulsen, Ian T., Elbourne, Liam D. H., Hassan, Karl A.   +7 more
openaire   +3 more sources

Evaluation of Delafloxacin against a Burkholderia pseudomallei Efflux Mutant Panel

Microbiology Spectrum, 2022
In vitro activities of delafloxacin and ciprofloxacin were evaluated against Burkholderia pseudomallei mutants expressing or lacking defined resistance-nodulation-cell division (RND) efflux pumps using CLSI methodology at pHs of 5.8 and 7.2. Delafloxacin
Sandra P. McCurdy, Nawarat Somprasong, Herbert P. Schweizer   +2 more
doaj   +1 more source

Diversity and conservation of RND efflux pumps across Escherichia coli [PDF]

, 2022
RND efflux pumps are located in the inner membrane of Gram-negative bacteria and form tripartite complexes that span the inner membrane, periplasm and outer membrane. It is widely accepted that Escherichia coli isolates possess six RND pumps; AcrB, AcrD,
Pugh, Hannah
core   +4 more sources

Structural Basis of Peptide-Based Antimicrobial Inhibition of a Resistance-Nodulation-Cell Division Multidrug Efflux Pump

Microbiology Spectrum, 2022
Bacterial efflux pumps in the resistance-nodulation-cell division (RND) family of Gram-negative bacteria contribute significantly to the development of antimicrobial resistance by many pathogens. In this study, we selected the MtrD transporter protein of
Meinan Lyu, Julio C. Ayala, Isabella Chirakos, Chih-Chia Su, William M. Shafer, Edward W. Yu   +5 more
doaj   +1 more source

Characteristics and diversity of mutations in regulatory genes of resistance-nodulation-cell division efflux pumps in association with drug-resistant clinical isolates of Acinetobacter baumannii

Antimicrobial Resistance and Infection Control, 2021
Background This study was aimed to characterize the genetic diversity and expression of three putative resistance-nodulation-cell division (RND)-type efflux systems and their contribution to multidrug efflux in clinical isolates of Acinetobacter ...
Bahare Salehi, Zohreh Ghalavand, Abbas Yadegar, Gita Eslami   +3 more
doaj   +1 more source

RND pumps across the Acinetobacter genus; AdeIJK is the ancestral efflux system

, 2022
Acinetobacter are generally soil-dwelling organisms that can also cause serious human infections. A. baumannii is one of the most common causative agents of Acinetobacter infections and is extensively drug resistant.
Darby, Elizabeth M.; id_orcid, Blair, Jessica M. A.; id_orcid, Dunn, Steven, McNally, Alan; id_orcid, Bavro, Vassiliy N.   +4 more
core   +1 more source

Alternative Model for RND-Type Efflux Pump

Journal of the Brazilian Chemical Society, 2016
RND (resistance-nodulation-division) transporters are found in several Gram-negative bacteria species. These proteins form a complex along with membrane fusion proteins and outer membrane factors. This complex acts as an efflux pump, transporting several different molecules directly from the cytoplasm to the extracellular medium.
Pedro Henrique Monteiro Torres, Pedro Geraldo Pascutti, Paulo Mascarello Bisch, Manuela Leal da Silva   +3 more
openaire   +4 more sources