Results 51 to 60 of about 4,835 (134)

ROLE OF RND-EFFLUX PUMP IN LEVOFLOXACIN RESISTANCE AMONG ACINETOBACTER BAUMANNII

IRAQI JOURNAL OF AGRICULTURAL SCIENCES, 2022
In this study out of 130 different clinical specimens, 70 Acinetobacter baumannii were collected from hospitalized patients. Then; all the isolates were characterized using biochemical tests and confirmed by using the Vitek II compact system. All isolates of Acinetobacter baumannii were subjected to the disc diffusion method to determine it's a ...
Ali M. A., S.S. Mahmood
openaire   +2 more sources

Targeting and ultrabroad insight into molecular basis of Resistance-nodulation-cell division efflux pumps

Scientific Reports, 2022
Resistance-nodulation-cell devision (RND) efflux pump variants have attracted a great deal of attention for efflux of many antibiotic classes, which leads to multidrug-resistant bacteria.
Hooria Seyedhosseini Ghaheh, Mohammad Sadegh Damavandi, Parisa Sadeghi, Ahmad Reza Massah, Taravat Hamidi Asl, Azhar Salari-Jazi, Seyed Hossein Hejazi   +6 more
doaj   +1 more source

Reducing bacterial antibiotic resistance by targeting bacterial metabolic pathways and disrupting RND efflux pump activity

Iberoamerican Journal of Medicine, 2022
Antibiotic resistance is a significant issue for the medical community, worldwide. Many bacteria develop drug resistance by utilizing multidrug resistant or MDR efflux pumps that can export antibiotics from bacterial cells.
Tatiana Hillman
doaj   +1 more source

Efflux pump genes of the resistance-nodulation-division family in Burkholderia cenocepacia genome

BMC Microbiology, 2006
Background Burkholderia cenocepacia is recognized as opportunistic pathogen that can cause lung infections in cystic fibrosis patients. A hallmark of B.
Manina Giulia, Arrigo Patrizio, Buroni Silvia, De Rossi Edda, Pasca Maria, Guglierame Paola, Riccardi Giovanna   +6 more
doaj   +1 more source

Phylogenetic analysis reveals an ancient gene duplication as the origin of the MdtABC efflux pump.

PLoS ONE, 2020
The efflux pumps from the Resistance-Nodulation-Division family, RND, are main contributors to intrinsic antibiotic resistance in Gram-negative bacteria. Among this family, the MdtABC pump is unusual by having two inner membrane components.
Kamil Górecki, Megan M McEvoy
doaj   +1 more source

Efflux pump-mediated resistance to new beta lactam antibiotics in multidrug-resistant gram-negative bacteria

Communications Medicine
The emergence and spread of bacteria resistant to commonly used antibiotics poses a critical threat to modern medical practice. Multiple classes of bacterial efflux pump systems play various roles in antibiotic resistance, and members of the resistance ...
Augusto Dulanto Chiang, John P. Dekker
doaj   +1 more source

Lack of AcrB Efflux Function Confers Loss of Virulence on Salmonella enterica Serovar Typhimurium

mBio, 2017
AcrAB-TolC is the paradigm resistance-nodulation-division (RND) multidrug resistance efflux system in Gram-negative bacteria, with AcrB being the pump protein in this complex.
Xuan Wang-Kan, Jessica M. A. Blair, Barbara Chirullo, Jonathan Betts, Roberto M. La Ragione, Alasdair Ivens, Vito Ricci, Timothy J. Opperman, Laura J. V. Piddock   +8 more
doaj   +1 more source

Systematic investigation of TetR-family transcriptional regulators and their roles on lignocellulosic inhibitor acetate tolerance in Zymomonas mobilis

Frontiers in Bioengineering and Biotechnology
TetR-family transcriptional regulators are widely distributed among bacteria and involved in various cellular processes such as multidrug and inhibitor resistance.
Yubei Xiao, Tongjia Qin, Tongjia Qin, Shuche He, Yunhao Chen, Han Li, Qiaoning He, Xia Wang, Shihui Yang   +8 more
doaj   +1 more source

Triclosan depletes the membrane potential in Pseudomonas aeruginosa biofilms inhibiting aminoglycoside induced adaptive resistance.

PLoS Pathogens, 2020
Biofilm-based infections are difficult to treat due to their inherent resistance to antibiotic treatment. Discovering new approaches to enhance antibiotic efficacy in biofilms would be highly significant in treating many chronic infections.
Michael M Maiden, Christopher M Waters
doaj   +1 more source

Beyond Antimicrobial Resistance: Evidence for a Distinct Role of the AcrD Efflux Pump in Salmonella Biology

mBio, 2016
For over 20 years, bacterial multidrug resistance (MDR) efflux pumps have been studied because of their impact on resistance to antimicrobials. However, critical questions remain, including why produce efflux pumps under non-antimicrobial treatment ...
Michelle M. C. Buckner, Jessica M. A. Blair, Roberto M. La Ragione, Jane Newcombe, Daniel J. Dwyer, Alasdair Ivens, Laura J. V. Piddock   +6 more
doaj   +1 more source