Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells. [PDF]
, 2017 The retinal degenerative diseases, which together constitute a leading cause of hereditary blindness worldwide, are largely untreatable. Development of reliable methods to culture complex retinal tissues from human pluripotent stem cells (hPSCs) could ...
Angueyra, Juan M +9 more
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Meckelin 3 is necessary for photoreceptor outer segment development in rat Meckel syndrome. [PDF]
PLoS ONE, 2013 Ciliopathies lead to multiorgan pathologies that include renal cysts, deafness, obesity and retinal degeneration. Retinal photoreceptors have connecting cilia joining the inner and outer segment that are responsible for transport of molecules to develop ...
Sarika Tiwari +5 more
doaj +1 more source
Mechanistically distinct mouse models for CRX-associated retinopathy [PDF]
, 2014 Cone-rod homeobox (CRX) protein is a "paired-like" homeodomain transcription factor that is essential for regulating rod and cone photoreceptor transcription. Mutations in human CRX are associated with the dominant retinopathies Retinitis Pigmentosa (RP),
Chen, Shiming +5 more
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Avian visual pigments: Characteristics, spectral tuning, and evolution [PDF]
, 2007 Birds are highly visual animals with complex visual systems. In this article, we discuss the spectral characteristics and genetic mechanisms of the spectral tuning of avian visual pigments.
Hart, NS, Hunt, DM
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Ecology and Evolution, 2022 Among major vertebrate groups, anurans (frogs and toads) are understudied with regard to their visual systems, and little is known about variation among species that differ in ecology.
Ryan K. Schott +4 more
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The cellular fate of mutant rhodopsin: quality control, degradation and aggresome formation [PDF]
, 2002 Mutations in the photopigment rhodopsin are the major cause of autosomal dominant retinitis pigmentosa. The majority of mutations in rhodopsin lead to misfolding of the protein.
Cheetham, ME +3 more
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RdgB2 is required for dim-light input into intrinsically photosensitive retinal ganglion cells. [PDF]
, 2015 A subset of retinal ganglion cells is intrinsically photosensitive (ipRGCs) and contributes directly to the pupillary light reflex and circadian photoentrainment under bright-light conditions.
Berson, David M +8 more
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Eye features and retinal photoreceptors of the nocturnal aardvark (Orycteropus afer, Tubulidentata).
PLoS ONEThe nocturnal aardvark Orycteropus afer is the only extant species in the mammalian order Tubulidentata. Previous studies have claimed that it has an all-rod retina.
Leo Peichl +9 more
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The Formation and Renewal of Photoreceptor Outer Segments
CellsThe visual system is essential for humans to perceive the environment. In the retina, rod and cone photoreceptor neurons are the initial sites where vision forms.
Jingjin Xu, Chengtian Zhao, Yunsi Kang
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In conditions of limited chromophore supply rods entrap 11-cis-retinal leading to loss of cone function and cell death [PDF]
, 2017 RPE65 is a retinoid isomerase required for the production of 11-cis-retinal, the chromophore of both cone and rod visual pigments. We recently established an R91W knock-in mouse strain as homologous animal model for patients afflicted by this mutation in
Arsenijevic, Yvan +12 more
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