Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death. [PDF]
, 2012 The altered metabolism of cancer can render cells dependent on the availability of metabolic substrates for viability. Investigating the signaling mechanisms underlying cell death in cells dependent upon glucose for survival, we demonstrate that glucose ...
Graeber, Thomas G +12 more
core
Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection [PDF]
, 2014 Enteropathogenic and enterohemorrhagic bacterial infections in humans are a severe cause of morbidity and mortality. Although NOD-like receptors (NLRs) NOD2 and NLRP3 have important roles in the generation of protective immune responses to enteric ...
Anand, Paras K +6 more
core +3 more sources
GSTM3 Function and Polymorphism in Cancer: Emerging but Promising
Cancer Management and Research, 2020 Shunda Wang, Jinshou Yang, Lei You, Menghua Dai,* Yupei Zhao* Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China*These ...
Wang S, Yang J, You L, Dai M, Zhao Y
doaj
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
VIPS: simple, efficient, and scalable cache coherence [PDF]
, 2016 Directory-based cache coherence is the de-facto standard for scalable shared-memory multi/many-cores and significant effort is invested in reducing its overhead.
Ros, Alberto
core +1 more source
Boundary regularity, Pohozaev identities, and nonexistence results
, 2017 In this expository paper we survey some recent results on Dirichlet problems of the form $Lu=f(x,u)$ in $\Omega$, $u\equiv0$ in $\mathbb R^n\backslash\Omega$. We first discuss in detail the boundary regularity of solutions, stating the main known results
Ros-Oton, Xavier
core +1 more source
High Density Lipoproteins Inhibit Oxidative Stress-Induced Prostate Cancer Cell Proliferation [PDF]
, 2018 Recent evidence suggests that oxidative stress can play a role in the pathogenesis and the progression of prostate cancer (PCa). Reactive oxygen species (ROS) generation is higher in PCa cells compared to normal prostate epithelial cells and this ...
Botta, Margherita +8 more
core +2 more sources
N-Butyrylated hyaluronic acid ameliorates gout and hyperuricemia in animal models
Pharmaceutical Biology, 2019 Context: Hyaluronic acid (HA) plays critical roles in the structural skeleton, joint lubrication, renal function and cell signaling. We previously showed that partially N-butyrylated, low molecular weight, hyaluronic acid (BHA) exhibited an anti ...
Lanzhou Li +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Hypobranching Induced by Both Environmental Antioxidants and ROS Metabolism Gene Knockouts in Neurospora Crassa [PDF]
, 2015 Previous work suggested a role of reactive oxygen species (ROS) metabolism on branch density, the statistical distribution of physical distances between branch points along a growing hypha in Neurospora. Here we report the results of experiments designed
Abduljabar, Hamzah +3 more
core +2 more sources