Results 1 to 10 of about 1,691 (128)

Transcriptomic profiling of thymic dysregulation and viral tropism after neonatal roseolovirus infection [PDF]

Frontiers in Immunology
IntroductionHerpesviruses, including the roseoloviruses, have been linked to autoimmune disease. The ubiquitous and chronic nature of these infections have made it difficult to establish a causal relationship between acute infection and subsequent ...
Andrei Belean, Eden Xue, Benjamin Cisneros, Elisha D. O. Roberson, Elisha D. O. Roberson, Elisha D. O. Roberson, Michael A. Paley, Michael A. Paley, Tarin M. Bigley, Tarin M. Bigley, Tarin M. Bigley   +10 more
doaj   +6 more sources

Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis [PDF]

Journal of Experimental Medicine, 2022
Infections with herpesviruses, including human roseoloviruses, have been proposed to cause autoimmune disease, but defining a causal relationship and mechanism has been difficult due to the ubiquitous nature of infection and development of autoimmunity long after acute infection.
Tarin M. Bigley, Liping Yang, Liang-I Kang, Jose B. Saenz, Francisco Victorino, Wayne M. Yokoyama   +5 more
core   +7 more sources

Past, present, and future perspectives on the diagnosis of Roseolovirus infections. [PDF]

Curr Opin Virol, 2014
Diagnosis of Roseolovirus infections mandates careful selection of patients, samples, and testing methods. We review advances in the field and highlight research priorities. Quantitative (q)PCR can accurately identify and distinguish between human herpesvirus 6 (HHV-6) species A and B.
Hill JA, Sedlak RH, Jerome KR.
europepmc   +6 more sources

Possible Relation of Roseolovirus Infection with Fibromyalgia / Iespējamā Roseolovīrusu Infekcijas Saistība Ar Fibromialīiju [PDF]

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences., 2016
Abstract Fibromyalgia (FM) is a chronic widespread pain disorder that impacts 0.5%-7% of the general population worldwide. The aetiology and pathogenesis of the disease are still unknown. Human herpesvirus-6 and -7 belong to the family Herpesviridae, subfamily Betaherpesvirinae, and genus Roseolovirus and are immunomodulating viruses ...
Svetlana Čapenko, Marija Mihailova, Santa Rasa, Angelika Krūmiņa, Zane Zazerska, Ināra Logina, Modra Murovska   +6 more
core   +6 more sources

CD8+ T Cells Prevent Lethality from Neonatal Murine Roseolovirus Infection [PDF]

The Journal of Immunology, 2017
Abstract A recently described mouse homolog of the human roseoloviruses, murine roseolovirus (MRV), causes loss of peripheral and thymic CD4+ cells during neonatal infection of BALB/c mice. Despite significant disruptions to the normal adaptive immune response, infected BALB/c mice reproducibly recover from infection, consistent with ...
Swapneel J Patel, Wayne M Yokoyama
openaire   +3 more sources

Porcine Cytomegalovirus/Porcine Roseolovirus, Previously Transmitted During Xenotransplantation, Does Not Infect Human 293T and Mouse Cells with Impaired Antiviral Defense [PDF]

Viruses
Porcine cytomegalovirus, more accurately classified as porcine roseolovirus (PCMV/PRV), was shown to be pathogenic in the context of xenotransplantation.
Hina Jhelum, Reinhold Schäfer, Benedikt B. Kaufer, Joachim Denner   +3 more
doaj   +2 more sources

Mouse Models for Human Herpesviruses [PDF]

Pathogens, 2023
More than one hundred herpesviruses have been isolated from different species so far, with nine infecting humans. Infections with herpesviruses are characterized by life-long latency and represent a significant challenge for human health.
Ivana Kutle, Anne Dittrich, Dagmar Wirth
doaj   +2 more sources

Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders [PDF]

Frontiers in Microbiology, 2018
Early-life infections and associated neuroinflammation is incriminated in the pathogenesis of various mood disorders. Infection with human roseoloviruses, HHV-6A and HHV-6B, allows viral latency in the central nervous system and other tissues, which can ...
Bhupesh K. Prusty, Bhupesh K. Prusty, Nitish Gulve, Sheila Govind, Gerhard R. F. Krueger, Julia Feichtinger, Julia Feichtinger, Lee Larcombe, Richard Aspinall, Dharam V. Ablashi, Carla T. Toro, Carla T. Toro   +11 more
doaj   +4 more sources

How Does a Porcine Herpesvirus, PCMV/PRV, Induce a Xenozoonosis. [PDF]

Int J Mol Sci
Porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV), a porcine herpesvirus, has been shown to significantly reduce the survival time of porcine xenotransplants in non-human primates.
Denner J.
europepmc   +3 more sources

Porcine Lymphotropic Herpesvirus (PLHV) Was Not Transmitted During Transplantation of Genetically Modified Pig Hearts into Baboons [PDF]

Int J Mol Sci
Porcine lymphotropic herpesviruses -1, -2, and -3 (PLHV-1, PLHV-2, and PLHV-3) are gammaherpesviruses that are widespread in pigs. These viruses are closely related to the human pathogens Epstein–Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus
Jhelum H, Bender M, Reichart B, Abicht J, Längin M, Kaufer B, Denner J.   +6 more
europepmc   +3 more sources