Results 1 to 10 of about 3,145,515 (147)

Transcriptomic profiling of thymic dysregulation and viral tropism after neonatal roseolovirus infection [PDF]

Frontiers in Immunology
IntroductionHerpesviruses, including the roseoloviruses, have been linked to autoimmune disease. The ubiquitous and chronic nature of these infections have made it difficult to establish a causal relationship between acute infection and subsequent ...
Andrei Belean, Eden Xue, Benjamin Cisneros, Elisha D. O. Roberson, Elisha D. O. Roberson, Elisha D. O. Roberson, Michael A. Paley, Michael A. Paley, Tarin M. Bigley, Tarin M. Bigley, Tarin M. Bigley   +10 more
doaj   +7 more sources

Past, present, and future perspectives on the diagnosis of Roseolovirus infections [PDF]

Current Opinion in Virology, 2014
Diagnosis of Roseolovirus infections mandates careful selection of patients, samples, and testing methods. We review advances in the field and highlight research priorities. Quantitative (q)PCR can accurately identify and distinguish between human herpesvirus 6 (HHV-6) species A and B.
Joshua A Hill, Keith R Jerome, Joshua A Hill   +2 more
exaly   +7 more sources

Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis [PDF]

Journal of Experimental Medicine, 2022
Infections with herpesviruses, including human roseoloviruses, have been proposed to cause autoimmune disease, but defining a causal relationship and mechanism has been difficult due to the ubiquitous nature of infection and development of autoimmunity long after acute infection.
Tarin M Bigley, Liping Yang, Liang-i Kang   +2 more
exaly   +6 more sources

CD8+ T Cells Prevent Lethality from Neonatal Murine Roseolovirus Infection [PDF]

Journal of Immunology, 2017
Abstract A recently described mouse homolog of the human roseoloviruses, murine roseolovirus (MRV), causes loss of peripheral and thymic CD4+ cells during neonatal infection of BALB/c mice. Despite significant disruptions to the normal adaptive immune response, infected BALB/c mice reproducibly recover from infection, consistent with ...
Swapneel J Patel, Wayne M Yokoyama
exaly   +6 more sources

Mouse Models for Human Herpesviruses [PDF]

Pathogens, 2023
More than one hundred herpesviruses have been isolated from different species so far, with nine infecting humans. Infections with herpesviruses are characterized by life-long latency and represent a significant challenge for human health.
Ivana Kutle, Anne Dittrich, Dagmar Wirth
doaj   +3 more sources

Possible Relation of Roseolovirus Infection with Fibromyalgia / Iespējamā Roseolovīrusu Infekcijas Saistība Ar Fibromialīiju [PDF]

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences., 2016
Abstract Fibromyalgia (FM) is a chronic widespread pain disorder that impacts 0.5%-7% of the general population worldwide. The aetiology and pathogenesis of the disease are still unknown. Human herpesvirus-6 and -7 belong to the family Herpesviridae, subfamily Betaherpesvirinae, and genus Roseolovirus and are immunomodulating viruses ...
Svetlana Čapenko, Marija Mihailova, Santa Rasa, Angelika Krūmiņa, Zane Zazerska, Ināra Logina, Modra Murovska   +6 more
semanticscholar   +4 more sources

First virological and pathological study of Göttingen Minipigs with Dippity Pig Syndrome (DPS). [PDF]

PLoS ONE, 2023
Dippity Pig Syndrome (DPS) is a well-known but rare complex of clinical signs affecting minipigs, which has not been thoroughly investigated yet. Clinically affected animals show acute appearance of red, exudating lesions across the spine.
Hina Jhelum, Nanna Grand, Kirsten Rosenmay Jacobsen, Sabrina Halecker, Michelle Salerno, Robert Prate, Luise Krüger, Yannick Kristiansen, Ludwig Krabben, Lars Möller, Michael Laue, Benedikt Kaufer, Kari Kaaber, Joachim Denner   +13 more
doaj   +2 more sources

First transplantation of a pig heart from a multiple gene‐modified donor, porcine cytomegalovirus/roseolovirus, and antiviral drugs

Xenotransplantation, 2023
Xenotransplantation, Volume 30, Issue 3, May/June 2023.
Joachim Denner
exaly   +2 more sources

An Approach to Controlling Inflammation and Coagulation in Pig-to-Baboon Cardiac Xenotransplantation. [PDF]

Xenotransplantation
ABSTRACT Introduction Inflammatory responses and coagulation disorders are a relevant challenge for successful cardiac xenotransplantation on its way to the clinic. To cope with this, an effective and clinically practicable anti‐inflammatory and anti‐coagulatory regimen is needed.
Bender M, Reichart B, Figueiredo C, Burgmann JM, Leuschen M, Wall F, Radan J, Neumann E, Mokelke M, Buttgereit I, Michel S, Ellgass R, Egerer S, Lange A, Baehr A, Kessler B, Kemter E, Klymiuk N, Denner J, Godehardt AW, Tönjes RR, Hagl C, Gebauer M, Binder U, Skerra A, Ayares D, Wolf E, Schmoeckel M, Brenner P, Längin M, Abicht JM.   +30 more
europepmc   +2 more sources

How to Detect Porcine Endogenous Retrovirus (PERV) Infections in Patients After Transplantation of Pig Organs. [PDF]

Xenotransplantation
ABSTRACT Porcine endogenous retroviruses (PERVs) are integrated into the genome of all pigs and can infect human cells in culture. However, no PERV infections have been reported in recipients following preclinical or clinical xenotransplantation or deliberate infection experiments.
Denner J, Jhelum H, Ban J, Krabben L, Kaufer BB.   +4 more
europepmc   +2 more sources