Results 11 to 20 of about 1,691 (128)

Monitoring for PERV Following Xenotransplantation. [PDF]

Transpl Int
Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs. PERV-A, PERV-B and PERV-C can be released as infectious virus particles and PERV-A and PERV-B can infect human cells in culture.
Denner J.
europepmc   +3 more sources

OMICS Analyses in Xenotransplantation: Initial Findings, Key Precautions, and Virus Infections. [PDF]

Xenotransplantation
ABSTRACT OMICS analyses have the potential to greatly enhance our understanding of rejection and other processes in xenotransplantation. These approaches may therefore contribute to extending the survival time of xenotransplants. Initial OMICS studies in brain‐dead patients following transplantation of pig kidneys or hearts revealed increased ...
Denner J.
europepmc   +2 more sources

Betaherpesvirus Incidence in Saliva Samples From Patients With Hematological Neoplasms: Frequency, Clinic and Diagnostic Insights. [PDF]

J Med Virol
ABSTRACT Hematological neoplasms (HN) are disorders originating in blood cells that hold significant epidemiological importance. Treatments available for these conditions can induce immunosuppression, and it increases the risk of viral infections and reactivations, mainly by Human betaherpesviruses (HCMV, HHV‐6, and HHV‐7).
Guimarães ACS, Gonçalves JP, Pereira NS, Bonfim FFO, Martinelli KG, Amarante MK, Yamada-Ogatta SF, Franco LC, Galhardi LCF, de Paula VS.   +9 more
europepmc   +2 more sources

The Endothelial Glycocalyx in Pig-to-Baboon Cardiac Xenotransplantation—First Insights [PDF]

Biomedicines
Cardiac xenotransplantation has seen remarkable success in recent years and is emerging as the most promising alternative to human cardiac allotransplantation.
Bender M, Abicht J, Reichart B, Leuschen M, Wall F, Radan J, Neumann E, Mokelke M, Buttgereit I, Michel S, Ellgass R, Gieseke K, Steen S, Paskevicius A, Denner J, Godehardt A, Tönjes R, Hagl C, Ayares D, Wolf E, Schmoeckel M, Brenner P, Müller M, Längin M.   +23 more
europepmc   +3 more sources

Combination of Anti-CD40 and Anti-CD40L Antibodies as Co-Stimulation Blockade in Preclinical Cardiac Xenotransplantation. [PDF]

Biomedicines
The blockade of the CD40/CD40L immune checkpoint is considered essential for cardiac xenotransplantation. However, it is still unclear which single antibody directed against CD40 or CD40L (CD154), or which combination of antibodies, is better at ...
Bender M, Abicht JM, Reichart B, Neumann E, Radan J, Mokelke M, Buttgereit I, Leuschen M, Wall F, Michel S, Ellgass R, Steen S, Paskevicius A, Lange A, Kessler B, Kemter E, Klymiuk N, Denner J, Godehardt AW, Tönjes RR, Burgmann JM, Figueiredo C, Milusev A, Zollet V, Salimi-Afjani N, Despont A, Rieben R, Ledderose S, Walz C, Hagl C, Ayares D, Wolf E, Schmoeckel M, Brenner P, Binder U, Gebauer M, Skerra A, Längin M.   +37 more
europepmc   +3 more sources

The landscape of viral associations in human cancers [PDF]

, 2020
Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential ...
Alawi, Malik, Borozan, Ivan, Brewer, Daniel S, Cooper, Colin S, Desai, Nikita, Eils, Roland, Ferretti, Vincent, Grundhoff, Adam, Iskar, Murat, Lichter, Peter, Moch, Holger, PCAWG Consortium, PCAWG Pathogens, Sültmann, Holger, Zapatka, Marc   +14 more
core   +8 more sources

Porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV): A threat for xenotransplantation? [PDF]

, 2022
The potential for a donor-derived transmission of porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV) to the recipient has been recognized since pigs were considered candidate donors for xenotransplantation.
Denner, Joachim, Mueller, Nicolas J
core   +4 more sources

Identification and Characterization of Two Novel Viruses in Ocular Infections in Reindeer [PDF]

, 2013
A thorough understanding of virus diversity in wildlife provides epidemiological baseline information about pathogens. In this study, eye swab samples were obtained from semi-domesticated reindeer (Rangifer tarandus tarandus) in Norway during an outbreak
Bodewes, R. (Rogier), das Neves, C.G. (Carlos), Haagmans, B.L. (Bart), Kuiken, T. (Thijs), Leeuwen, M. (Marije) van, Osterhaus, A.D.M.E. (Albert), Schapendonk, C.M.E. (Claudia), Smits, S.L. (Saskia), Stalin Raj, V.S., Tryland, M. (Morten)   +9 more
core   +13 more sources

Differential Impacts of HHV-6A versus HHV-6B Infection in Differentiated Human Neural Stem Cells [PDF]

, 2022
Within the family Herpesviridae, sub-family β-herpesvirinae, and genus Roseolovirus, there are only three human herpesviruses that have been described: HHV-6A, HHV-6B, and HHV-7.
Bahramian, Elham, Ceballos, Ruben Michael, Furr, Mercede, Wu, Jerry T.   +3 more
core   +7 more sources

First virological and pathological study of Göttingen Minipigs with Dippity Pig Syndrome (DPS).

PLoS ONE, 2023
Dippity Pig Syndrome (DPS) is a well-known but rare complex of clinical signs affecting minipigs, which has not been thoroughly investigated yet. Clinically affected animals show acute appearance of red, exudating lesions across the spine.
Hina Jhelum, Nanna Grand, Kirsten Rosenmay Jacobsen, Sabrina Halecker, Michelle Salerno, Robert Prate, Luise Krüger, Yannick Kristiansen, Ludwig Krabben, Lars Möller, Michael Laue, Benedikt Kaufer, Kari Kaaber, Joachim Denner   +13 more
doaj   +1 more source