Results 11 to 20 of about 13,764 (183)

Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction. [PDF]

PLoS ONE, 2018
Current therapeutics for hepatitis B virus (HBV) patients such as nucleoside analogs (NAs) are effective; however, new antiviral drugs against HBV are still desired.
Yuta Tsukamoto, Sotaro Ikeda, Koji Uwai, Riho Taguchi, Kazuaki Chayama, Takemasa Sakaguchi, Ryo Narita, Wan-Ling Yao, Fumihiko Takeuchi, Yukie Otakaki, Koichi Watashi, Takaji Wakita, Hiroki Kato, Takashi Fujita   +13 more
doaj   +1 more source

Pharmacokinetics, Safety and Tolerability of Melissa officinalis Extract which Contained Rosmarinic Acid in Healthy Individuals: A Randomized Controlled Trial. [PDF]

PLoS ONE, 2015
The aim of this study was to evaluate the safety, tolerability and pharmacokinetics of single dose of Melissa officinalis extract which contained rosmarinic acid, including food-effects in healthy individuals.
Moeko Noguchi-Shinohara, Kenjiro Ono, Tsuyoshi Hamaguchi, Kazuo Iwasa, Toshitada Nagai, Shoko Kobayashi, Hiroyuki Nakamura, Masahito Yamada   +7 more
doaj   +1 more source

Short Chain (≤C4) Esterification Increases Bioavailability of Rosmarinic Acid and Its Potency to Inhibit Vascular Smooth Muscle Cell Proliferation

Frontiers in Pharmacology, 2021
Rosmarinic acid is a natural phenolic acid and active compound found in many culinary plants, such as rosemary, mint, basil and perilla. Aiming to improve the pharmacokinetic profile of rosmarinic acid and its activity on vascular smooth muscle cell ...
Tina Blažević, Gottfried Reznicek, Limin Ding, Gangqiang Yang, Patricia Haiss, Elke H. Heiss, Verena M. Dirsch, Rongxia Liu   +7 more
doaj   +1 more source

Investigation of antioxidant effects of rosmarinic acid on liver, lung and kidney in rats: a biochemical and histopathological study

Folia Morphologica, 2020
Background: The aim of the study was to investigate the protective effects of rosmarinic acid in rats exposed to hepatic ischaemia/reperfusion (I/R) injury.
A. Oğuz, A. Böyük, A. Ekinci, U. Alabalik, A. Türkoğlu, M. C. Tuncer, A. Ekingen, E. Deveci, B. Gültürk, U. Aday   +9 more
doaj   +1 more source

Comparison of Analgesic Effect of Rosmarinic Acid With Piroxicam in Mice [PDF]

International Journal of Basic Science in Medicine, 2022
Introduction: Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most widely used drugs in the treatment of pain and inflammation. Although, their side effects i.e.; gastrointestinal and renal adverse effects, limit the use of these drugs ...
Mohsen Moradi, Mahdi Mashhadi Akbar Boojar, Mehdi Saberi, Hamidreza Rahimi Salkuyeh, Maryam Ghorbani, Hasan Amanpour, Fateme Salem   +6 more
doaj   +1 more source

Rosmarinic Acid Exhibits a Lipid-Lowering Effect by Modulating the Expression of Reverse Cholesterol Transporters and Lipid Metabolism in High-Fat Diet-Fed Mice

Biomolecules, 2021
Hyperlipidemia is a potent risk factor for the development of cardiovascular diseases. The reverse cholesterol transport (RCT) process has been shown to alleviate hyperlipidemia and protect against cardiovascular diseases.
Jean Baptiste Nyandwi, Young Shin Ko, Hana Jin, Seung Pil Yun, Sang Won Park, Hye Jung Kim   +5 more
doaj   +1 more source

Stability of Rosmarinic Acid in Aqueous Extracts from Different Lamiaceae Species after in vitro Digestion with Human Gastrointestinal Enzymes

Food Technology and Biotechnology, 2016
The present study compares the gastrointestinal stability of rosmarinic acid in aqueous extracts of thyme, winter savory and lemon balm with the stability of pure rosmarinic acid.
Zoran Zorić, Joško Markić, Sandra Pedisić, Viljemka Bučević-Popović, Ivana Generalić-Mekinić, Katarina Grebenar, Tea Kulišić-Bilušić   +6 more
doaj   +1 more source

Potential of Different Coleus blumei Tissues for Rosmarinic Acid Production

Food Technology and Biotechnology, 2015
Rosmarinic acid is one of the main active components of Coleus blumei and is known to have numerous health benefi ts. The pharmacological significance of rosmarinic acid and its production through in vitro culture has been the subject of numerous studies.
Nataša Bauer, Rosemary Vuković, Saša Likić, Sibila Jelaska   +3 more
doaj   +1 more source

New insights into rosmarinic acid biosynthesis based on molecular studies

Current Plant Biology, 2020
The knowledge about rosmarinic acid has been growing continuously since it has been first elucidated. It has various types of biological activities and it proved to be an excellent therapeutic agent.
Eszter Trócsányi, Zsuzsanna György, Éva Zámboriné-Németh   +2 more
doaj   +1 more source

Protective Effects of Rosmarinic Acid on Testicular Torsion-Detorsion in an Animal Model [PDF]

Iranian Journal of Veterinary Surgery, 2022
Testicular torsion is a disorder that may cause infertility or subfertility in males. Rosmarinic acid (RA) is a natural polyphenol with potent antioxidant effects that its protective effects in ischemia/reperfusion (I/R) injury in the hepatic, renal ...
Abbas Raisi, Farshid Davoodi, Rahim Mohammadi   +2 more
doaj   +1 more source