Results 21 to 30 of about 64,618 (285)

Microglial activation contributes to cognitive impairments in rotenone-induced mouse Parkinson’s disease model

Journal of Neuroinflammation, 2021
Background Cognitive decline occurs frequently in Parkinson’s disease (PD), which greatly decreases the quality of life of patients. However, the mechanisms remain to be investigated.
Dongdong Zhang, Sheng Li, Liyan Hou, Lu Jing, Zhengzheng Ruan, Bingjie Peng, Xiaomeng Zhang, Jau-Shyong Hong, Jie Zhao, Qingshan Wang   +9 more
doaj   +1 more source

Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I. [PDF]

, 2013
Verrucosidin (VCD) belongs to a group of fungal metabolites that were identified in screening programs to detect molecules that preferentially kill cancer cells under glucose-deprived conditions.
Chen, Thomas C, Gonzalez, Reyna, Hofman, Florence M, Louie, Stan G, Pao, Peng-Wen, Pirrung, Michael C, Schönthal, Axel H, Sharma, Natasha, Thomas, Simmy   +8 more
core   +2 more sources

Forced exercise activates the NrF2 pathway in the striatum and ameliorates motor and behavioral manifestations of Parkinson's disease in rotenone-treated rats

Behavioral and Brain Functions, 2020
Background Parkinson's disease (PD) is a common neurodegenerative disorder characterized by progressive loss of nigrostriatal dopaminergic neurons leading to dopamine depletion and problems of movement, emotions, and cognition.
Dina M. Monir, Motamed E. Mahmoud, Omyma G. Ahmed, Ibrahim F. Rehan, Amany Abdelrahman   +4 more
doaj   +1 more source

Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always [PDF]

, 2017
Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive RGCs deputed to non-image forming functions of the eye such as synchronization of circadian rhythms to light-dark cycle.
Carelli, Valerio, Georg, Birgitte, Ghelli, Anna, Giordano, Carla, Hannibal, Jens, La Morgia, Chiara, Ross Cisneros, Fred N., Sadun, Alfredo A.   +7 more
core   +1 more source

Surface Fluorescence Studies of Tissue Mitochondrial Redox State in Isolated Perfused Rat Lungs [PDF]

, 2012
We designed a fiber-optic-based optoelectronic fluorometer to measure emitted fluorescence from the auto-fluorescent electron carriers NADH and FAD of the mitochondrial electron transport chain (ETC).
Audi, Said H., Jacobs, Elizabeth R., Ranji, Mahsa, Sepehr, Reyhaneh, Staniszewski, Kevin   +4 more
core   +2 more sources

Reversal effect of Solanum dasyphyllum against rotenone-induced neurotoxicity

Current Issues in Pharmacy and Medical Sciences, 2020
We earlier reported the protective effect of Solanum dasyphyllum against cyanide neurotoxicity. In furtherance to this, we investigated the protective effect of S.
Ilesanmi Omotayo B., Efe Obade, Odewale Temitope T., Atanu Francis O., Adeogun Esther F., Akinmoladun Afolabi C., Olaleye Tolulope M.   +6 more
doaj   +1 more source

Transcriptome analysis of a rotenone model of parkinsonism reveals complex I-tied and -untied toxicity mechanisms common to neurodegenerative diseases. [PDF]

PLoS ONE, 2012
The pesticide rotenone, a neurotoxin that inhibits the mitochondrial complex I, and destabilizes microtubules (MT) has been linked to Parkinson disease (PD) etiology and is often used to model this neurodegenerative disease (ND).
Yofre Cabeza-Arvelaiz, Robert H Schiestl
doaj   +1 more source

Neuroprotective effect of butin against rotenone-induced Parkinson’s disease mediated by antioxidant and anti-inflammatory actions through paraoxonase-1-induction

Journal of Taibah University for Science, 2022
This investigation aimed to assess the anti-Parkinson's effect of butin in rotenone-treated rats. A total of 24 albino Wistar rats were segregated into four groups equally as follows: Group I (normal) and Group II (rotenone control); Group III and Group ...
Fahad A. Al-Abbasi
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Functional and Biogenetical Heterogeneity of the Inner Membrane of Rat-Liver Mitochondria [PDF]

, 1971
Rat liver mitochondria were fragmented by a combined technique of swelling, shrinking, and sonication. Fragments of inner membrane were separated by density gradient centrifugation.
Allmann D. W., Ashwell M., Beattie D. S., Beattie D. S., Brunner G., Burstone M. S., Davis K. A., Delbruck A., Fiske C. H., Folch J., Gear A. R. L., Gear A. R. L., Gear A. R. L., Gelder B. F., Gotterer G. S., Hasegawa E., Hawley E. S., Johnson A. B., Klingenberg M., Kuntzel H., Labbe R. F., Lentz P. E., Neupert W., Neupert W., Novikoff A. B., Ohnishi K., Omura T., Parsons D. F., Parsons D. F., Pette D., Pollak J. K., Pullmann M. E., Raw J., Raw J., Reith A., Schneider W. C., Schuel H., Schumacher H.-H., Sebald W., Sebald W., Seligman A. M., Sies H., Sottocasa G. L., Stoffel W., Strecker H. J., Swick R. W., Szarkowska L., Tabor C. W., Tol A., Vazquez J. J., Yonetani T.   +50 more
core   +1 more source

Spirulina Ameliorates Oxidative Damage and Inflammation in Rotenone-Induced Neurotoxicity in Male Mice

International Journal of Medical Toxicology and Forensic Medicine, 2022
Background: Rotenone, a chemical compound produced naturally by leguminous plants, has conventionally been used as a pesticide by blocking the uptake of oxygen by body cells.
Marwa E.A. EL- Shamarka , Ahmed M.S. Hussein , Ola N. Sayed, Eman S Said, Marwa A Mwaheb   +4 more
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