Results 41 to 50 of about 65,398 (283)

A highly reproducible rotenone model of Parkinson's disease

Neurobiology of Disease, 2009
The systemic rotenone model of Parkinson's disease (PD) accurately replicates many aspects of the pathology of human PD and has provided insights into the pathogenesis of PD.
Jason R. Cannon, Victor Tapias, Hye Mee Na, Anthony S. Honick, Robert E. Drolet, J. Timothy Greenamyre   +5 more
doaj   +1 more source

Efficacy of different insecticides and a repellent against the European pear sucker (Cacopsylla pyri) [PDF]

, 2004
The efficacy of different insecticides (neem, pyrethrin, spinosad, and rotenone) and a repellent (kaolin) applied with different strategies (single or repeated applications) against the over-wintering pear suckers (Cacopsylla pyri) and nymphs of the ...
Daniel, Claudia, Wyss, Eric
core  

Serine one-carbon catabolism with formate overflow [PDF]

, 2016
Serine catabolism to glycine and a one-carbon unit has been linked to the anabolic requirements of proliferating mammalian cells. However, genome-scale modeling predicts a catabolic role with one-carbon release as formate. We experimentally prove that in
Athineos, Dimitris, Blyth, Karen, Gottlieb, Eyal, Kamphorst, Jurre J., Labuschagne, Christiaan Fred, Mackay, Gillian M., Maddocks, Oliver, Meiser, Johannes, Tumanov, Sergey, Van Den Broek, Niels, Vazquez, Alexei, Vousden, Karen   +11 more
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Effects of Low Concentrations of Rotenone Upon Mitohormesis in SH-SY5Y Cells

Dose-Response, 2013
The mitochondrial toxin rotenone exerts cytotoxicity via overproduction of reactive oxygen species (ROS) and depolarization of the mitochondrial membrane.
Xiong Yuyun, Qian Jinjun, Xu Minfang, Qiu Jing, Xia Juan, Ma Rui, Zhu Li, Gao Jing   +7 more
doaj   +1 more source

Standardization of the bio-active compounds (rotenoids) from the extract of local plant species (derris elliptica) using the internal standard method of high performance liquid chromatography (HPLC) [PDF]

, 2005
It is well known now that some plant species represent an efficient factory of chemicals, which are manufactured and used as bio-weapons against pest attacks. Extensive work has been done during the last few decades on these potentially useful compounds.
M. R., Sarmidi, R. A., Aziz, Saiful Irwan, Zubairi   +2 more
core  

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

Advanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava, Alireza Rafieerad, Weiang Yan, Keshav Narayan Alagarsamy, Qingdong Guan, Leena Regi Saleth, Michel Aliani, Sanjiv Dhingra   +7 more
wiley   +1 more source

Assessment of the direct and indirect effects of MPP+ and dopamine on the human proteasome: implications for Parkinson's disease aetiology [PDF]

, 2008
Mitochondrial impairment, glutathione depletion and oxidative stress have been implicated in the pathogenesis of Parkinson’s disease (PD), linked recently to proteasomal dysfunction.
Beck, KE, Billett, EE, Caneda-Ferrón, B, Costa, T, De, Girolamo, Layfield, R   +5 more
core   +1 more source

Mitochondrial Transplantation via Magnetically Responsive Artificial Cells Promotes Intracerebral Hemorrhage Recovery by Supporting Microglia Immunological Homeostasis

Advanced Materials, Volume 37, Issue 13, April 2, 2025.
A type of magnetically responsive artificial cells (ACs) has been developed, demonstrating the loading of mitochondria and self‐enclosure processes to ensure the protection of mitochondrial transport via the bloodstream. The treatment with ACs effectively transplanted mitochondria around the lesion, thereby improving neurological recovery by supporting
Mi Zhou, Jinhui Zang, Yuxuan Qian, Qiang Zhang, Yifan Wang, Tingting Yao, Hongyu Yan, Kai Zhang, Xiaojun Cai, Lixian Jiang, Yuanyi Zheng   +10 more
wiley   +1 more source

Rotenone inhibited osteosarcoma metastasis by modulating ZO-2 expression and location via the ROS/Ca2+/AMPK pathway

Redox Report
Background Pulmonary metastases in osteosarcoma (OS) are associated with a poor prognosis. Rotenone has shown anti-cancer activity. However, its effects on metastasis and the underlying mechanisms remain unknown. This study investigated the potential use
Xiang Ma, Zhen Li, Hengwei Ma, Kun Jiang, Bao Chen, Weiquan Wang, Ziqiang Zhu, Jianqiang Wang, Zuozhang Yang, Wang Yunqing, Suwei Dong   +10 more
doaj   +1 more source