Results 81 to 90 of about 35,461 (280)

Lipidic nanocapsule drug delivery : neuronal protection for cochlear implant optimization [PDF]

, 2012
Objective: Sensorineural hearing loss leads to the progressive degeneration of spiral ganglion cells (SGC). Next to postoperative fibrous tissue growth, which should be suppressed to assure a close nerve–electrode interaction, the density of healthy SGC ...
Meyer, Hartwig, Scheper, Verena, Saulnier, Patrick, F. Fouchet, Fouchet, Florian, Stöver, Timo, P. Saulnier, H. Meyer, W. Bäumer, V. Scheper, Bastiat, Guillaume, Bäumer, Wolfgang, Lenarz, Thomas, T. Stöver, T. Lenarz, G. Bastiat   +15 more
core   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The secondary spiral lamina and its relevance in cochlear implant surgery

Upsala Journal of Medical Sciences, 2018
Objective: We used synchrotron radiation phase contrast imaging (SR-PCI) to study the 3D microanatomy of the basilar membrane (BM) and its attachment to the spiral ligament (SL) (with a conceivable secondary spiral lamina [SSL] or secondary spiral plate)
Sumit Agrawal, Nadine Schart-Morén, Wei Liu, Hanif M. Ladak, Helge Rask-Andersen, Hao Li   +5 more
doaj   +1 more source

Cochlear hair cell loss in single-dose versus continuous round window administration of gentamicin [PDF]

, 2005
CONCLUSIONS: Gentamicin-induced cochlear hair cell loss depends on local middle ear administration kinetics and the total drug dose. Single-dose gentamicin instillation in the middle ear is associated with a high variation in hair cell loss.
Laurell, G,, Laurell, Göran,, Bagger-Sjöbäck, Dan,, Wagner, N, Thomsen, J, Cayé-Thomasen, Per,, Thomsen, Jens,, Cayé-Thomasen, P, Bagger-Sjöbäck, D, Wagner, Niels,   +9 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Formation and characterisation of hydrogel diffusion channels for directed drug delivery

Current Directions in Biomedical Engineering, 2019
Drug Delivery Systems (DDS) are frequently operating in a surrounding liquid environment, such as blood in the case of drug-eluting stents or perilymph in the case of cochlear implants.
Eickner Thomas, Kohse Stefanie, Illner Sabine, Oschatz Stefan, Teske Michael, Rekowska Natalia, Senz Volkmar, Schmitz Klaus-Peter, Grabow Niels   +8 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Middle ear biofilm and sudden deafness - a light and transmission electron microscopy study

Frontiers in Neurology
BackgroundThere still exists controversy about whether the healthy human middle ear mucosa is sterile or if it may harbor a diverse microbiome. Considering the delicacy of the human round window membrane (RWM), different mechanisms may exist for avoiding
Hao Li, Karin Staxäng, Hanif M. Ladak, Hanif M. Ladak, Hanif M. Ladak, Sumit Agrawal, Sumit Agrawal, Sumit Agrawal, Helge Rask-Andersen   +8 more
doaj   +1 more source

The round window region and contiguous areas: endoscopic anatomy and surgical implications [PDF]

, 2015
The round window region is a critical area of the middle ear; the aim of this paper is to describe its anatomy from an endoscopic perspective, emphasizing some structures, the knowledge of which could have important implications during surgery, as well ...
PRESUTTI, Livio, Alicandri-Ciufelli M., MARCHIONI, Daniele, Rubini, Alessia, M. Alicandri Ciufelli, Pothier, David D, ALICANDRI CIUFELLI, Matteo, Rubini A., L. Presutti, Pothier D. D., Presutti L., A. Rubini, Marchioni D., D.D. Pothier   +13 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source