Results 51 to 60 of about 37,245 (219)

rpoB Gene Sequence-Based Identification of Staphylococcu s Species [PDF]

Journal of Clinical Microbiology, 2002
ABSTRACT The complete sequence of rpoB , the gene encoding the beta subunit of RNA polymerase was determined for Staphylococcus saccharolyticus , Staphylococcus lugdunensis , S taphylococcus caprae , and Staphylococcus ...
Michel, Drancourt, Didier, Raoult
openaire   +2 more sources

Interpreting very low Mycobacterium tuberculosis detected on Xpert Mycobacterium tuberculosis/rifampicin

Lung India, 2019
The development and rollout of the Xpert® Mycobacterium tuberculosis/rifampicin assay for the GeneXpert platform is considered an important breakthrough in the fight against tuberculosis.
Kanchan Ajbani, Swapna Naik, Mubin Kazi, Anjali Shetty, Camilla Rodrigues   +4 more
doaj   +1 more source

Whole-genome sequencing of two clinical strains of Mycobacterium tuberculosis with phenotypic susceptibility to rifampicin but predicted resistance by Xpert MTB/RIF

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. More than 40% of Mycobacterium tuberculosis strains are resistant to rifampicin (RIF) and isoniazid, the first-line drugs. The tuberculosis pathogen becomes resistant to RIF mainly due to mutations in the rpoB gene. The aim of the study was
Oleg B. Ogarkov, Viacheslav V. Sinkov, Tatyana A. Kuhtina, Svetlana N. Zhdanova, Ilya G. Kondratov   +4 more
doaj   +1 more source

Properties of Multidrug-Resistant Mutants Derived from Heterologous Expression Chassis Strain Streptomyces albidoflavus J1074

Microorganisms, 2023
Streptomyces albidoflavus J1074 is a popular platform to discover novel natural products via the expression of heterologous biosynthetic gene clusters (BGCs).
Borys Dolya, Olena Hryhorieva, Khrystyna Sorochynska, Maria Lopatniuk, Iryna Ostash, Vasylyna-Marta Tseduliak, Eva Baggesgaard Sterndorff, Tue Sparholt Jørgensen, Tetiana Gren, Yuriy Dacyuk, Tilmann Weber, Andriy Luzhetskyy, Victor Fedorenko, Bohdan Ostash   +13 more
doaj   +1 more source

Presence of New Delhi metallo-β-lactamase gene (NDM-1) in a clinical isolate of Acinetobacter junii in Argentina [PDF]

, 2016
Here we report the presence of a clinically significant A. junii blaNDM-1 positive in a 38-year-old woman who was admitted to the emergency department with a fever and leg ulcers with signs of infection.
Almuzara, Marisa, Barberis, Claudia, Cittadini, Roxana, Del Castillo M,, Lazzaro, T., Montaña, Sabrina Daiana, Ramírez, M. S., Uong, S., Vay, Carlos Alberto   +8 more
core   +1 more source

Impact of rpoB Mutations on Reduced Vancomycin Susceptibility in Staphylococcus aureus [PDF]

Journal of Clinical Microbiology, 2011
ABSTRACT Of 38 vancomycin-intermediate Staphylococcus aureus (VISA) clinical strains, 27 (71%) possessed a mutation(s) in rpoB encoding the β-subunit of RNA polymerase. Furthermore, 95.6% of the rifampin-resistant mutants obtained from 9 methicillin-resistant S. aureus
Yukiko, Watanabe, Longzhu, Cui, Yuki, Katayama, Kishii, Kozue, Keiichi, Hiramatsu   +4 more
openaire   +2 more sources

Characterization of Genetic Variants Associated with Rifampicin Resistance Level in Mycobacterium tuberculosis Clinical Isolates Collected in Guangzhou Chest Hospital, China

Infection and Drug Resistance, 2022
HM Adnan Hameed1– 4*, Cuiting Fang1– 4*, Zhiyong Liu,1– 3 Yanan Ju,1– 3 Xingli Han,1– 4 Yamin Gao,1– 4 Shuai Wang,1– 3,5 Gift Chiwala,1– 4 Yaoju Tan,6 Ping Guan,6 Jinxing Hu,6 Xiaoli Xiong,1– 3 Jiacong Peng,3,7 Yongping Lin,3,7 Muzammal Hussain,4
Hameed HMA, Fang C, Liu Z, Ju Y, Han X, Gao Y, Wang S, Chiwala G, Tan Y, Guan P, Hu J, Xiong X, Peng J, Lin Y, Hussain M, Zhong N, Maslov DA, Cook GM, Liu J, Zhang T   +19 more
doaj  

Occurrence of disputed rpoB mutations among Mycobacterium tuberculosis isolates phenotypically susceptible to rifampicin in a country with a low incidence of multidrug-resistant tuberculosis

BMC Infectious Diseases, 2019
Background Accurate drug susceptibility testing (DST) of Mycobacterium tuberculosis in clinical specimens and culture isolates to first-line drugs is crucial for diagnosis and management of multidrug-resistant tuberculosis (MDR-TB).
Noura M. Al-Mutairi, Suhail Ahmad, Eiman Mokaddas, Hanaa S. Eldeen, Susan Joseph   +4 more
doaj   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Mutations inside rifampicin-resistance determining region of rpoB gene associated with rifampicin-resistance in Mycobacterium tuberculosis

Journal of Infection and Public Health, 2018
Background: Rifampicin (RIF) plays a pivotal role in the treatment of tuberculosis due to its bactericidal effects. Because the action of RIF is on rpoB gene encoding RNA polymerase β subunit, 95% of RIF resistant mutations are present in rpoB gene.
Myo T. Zaw, Nor A. Emran, Zaw Lin
doaj   +1 more source