Results 61 to 70 of about 508,064 (311)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Regulatory Aspects of rRNA Modification and Pre-rRNA Processing
, 2014 The major types of posttranscriptional modification are the isomerization of uracil to pseudouridine, 2′-O-methylation of the ribose moieties and base methylation. In addition to their roles in pre-rRNA modification, both Dim1p and Cbf5p are required for pre-rRNA processing, and Pet56p is required for synthesis of mitochondrial large ribosomal subunits.
Lafontaine, Denis, Tollervey, D
openaire +2 more sources
The 23S rRNA gene PCR-RFLP used for characterization of porcine intestinal spirochete isolates
, 2006 Using three reference strains of Brachyspira hyodysenteriae (B204, B234, B169), one B. pilosicoli (P43/6/78), one B. murdochii (56-150), one B. intermedia (PWS/A), one B. innocens (B256) and ten Korean isolates, PCR-RFLP analysis of DNA encoding 23S rRNA
Lee, J.L. +3 more
core +1 more source
Microbial CellIn Saccharomyces cerevisiae, polyadenylated forms of mature (and not precur-sor) small non-coding RNAs (sncRNAs) those fail to undergo proper 3-end mat-uration are subject to an active degradation by Rrp6p and Rrp47p, which does not require the ...
Anusha Chaudhuri +3 more
doaj +1 more source
Locus-specific ribosomal RNA gene silencing in nucleolar dominance. [PDF]
PLoS ONE, 2007 The silencing of one parental set of rRNA genes in a genetic hybrid is an epigenetic phenomenon known as nucleolar dominance. We showed previously that silencing is restricted to the nucleolus organizer regions (NORs), the loci where rRNA genes are ...
Michelle S Lewis +4 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Eukaryotic 5S rRNA biogenesis [PDF]
WIREs RNA, 2011 AbstractThe ribosome is a large complex containing both protein and RNA which must be assembled in a precise manner to allow proper functioning in the critical role of protein synthesis. 5S rRNA is the smallest of the RNA components of the ribosome, and although it has been studied for decades, we still do not have a clear understanding of its function
Martin, Ciganda, Noreen, Williams
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Rlp7p is associated with 60S preribosomes, restricted to the granular component of the nucleolus, and required for pre-rRNA processing [PDF]
, 2002 Many analyses have examined subnucleolar structures in eukaryotic cells, but the relationship between morphological structures, pre-rRNA processing, and ribosomal particle assembly has remained unclear.
Tollervey, D +13 more
core +1 more source
Progenitor‐derived ribosomal RNA supports protein synthesis in Drosophila neurons
Natural Sciences, 2022 Global mRNA translation may differ dramatically between progenitor cells and their differentiated progeny. One way cell type‐specific translation is established is through ribosome concentration.
Jade Fee +2 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source