Results 41 to 50 of about 1,917,084 (305)
, 2011 Copyright information:Taken from " and investigation of bacterial type B RNase P interaction with tRNA 3′-CCA"Nucleic Acids Research 2007;35(6):2060-2073.Published online 13 Mar 2007PMCID:PMC1874595.© 2007 The Author(s) PCR products were analyzed on a ...
Roland K. Hartmann (8016) +1 more
core +1 more source
Evaluación comparativa de RT-PCR punto final, RT-PCR en tiempo real y RT-LAMP en el diagnóstico del virus GLRaV-3 asociado al enrollamiento de la hoja en plantas de vid [PDF]
, 2021 El enrollamiento de la hoja de la vid (grapevine leafroll disease, GLD) es causada por un complejo de virus de la familia Closteroviridae; dentro de estos, el virus más representativo de la enfermedad es el GLRaV-3, perteneciente a la especie Grapevine ...
Odett Mariana Sandez Salas
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Evaluation of a saliva molecular point of care for the detection of SARS-CoV-2 in ambulatory care
Scientific Reports, 2021 Rapid identification of SARS-CoV-2-infected individuals is a cornerstone for the control of virus spread. The sensitivity of SARS-CoV-2 RNA detection by RT-PCR is similar in saliva and nasopharyngeal swabs.
Jérôme LeGoff +17 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Nested-RT-PCR and Multiplex RT-PCR for Diagnosis of Rhinovirus Infection in Clinical Samples [PDF]
, 2014 Human rhinoviruses (HRVs) are positive-stranded RNA viruses belonging to the Enterovirus genus in the family of Picornaviridae. Identification of the specific strain in HRV disease has been difficult because the traditional serological method is insensitive, labor intensive, and cumbersome. With the fast progress in molecular biological technique, more
Yu, Xuelian, Ghildyal, Reena
openaire +2 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source